2-(1-Allyl-2-bromo-cyclopent-2-enyl)-pent-4-enoic acid | 645421-56-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-(1-Allyl-2-bromo-cyclopent-2-enyl)-pent-4-enoic acid
• 英文别名: 2-(2-Bromo-1-prop-2-enylcyclopent-2-en-1-yl)pent-4-enoic acid
• CAS: 645421-56-3
• 化学式: C₁₃H₁₇BrO₂
• 分子量: 285.181
• InChiKey: IBZFWNDZNBNSNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 2-(1-Allyl-2-bromo-cyclopent-2-enyl)-pent-4-enoic acid 以96%的产率得到1-Bromo-spiro[4.5]deca-1,8-diene-6-carboxylic acid methyl ester
  参考文献：
  名称：

  A sequential Claisen/ring-closing metathesis approach to the synthesis of spirocyclic cyclopentanes and cyclohexanes

  摘要：

  A new method for the formation of spirocycles is described using a sequential Ireland-Claisen/Metathesis strategy to construct spirocyclic systems. Optimization of the Ireland-Claisen conditions provides the key metathesis substrates. The metathesis reactions were highly regioselective by virtue of steric hindrance in the substrate olefins. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.09.190
• 作为产物：
  描述：

  3-Allyl-2-bromo-cyclopent-2-enol 在 三甲基氯硅烷 、 双(三甲基硅烷基)氨基钾 、 三乙胺 作用下， 以 甲苯 为溶剂， 生成 2-(1-Allyl-2-bromo-cyclopent-2-enyl)-pent-4-enoic acid
  参考文献：
  名称：

  A sequential Claisen/ring-closing metathesis approach to the synthesis of spirocyclic cyclopentanes and cyclohexanes

  摘要：

  A new method for the formation of spirocycles is described using a sequential Ireland-Claisen/Metathesis strategy to construct spirocyclic systems. Optimization of the Ireland-Claisen conditions provides the key metathesis substrates. The metathesis reactions were highly regioselective by virtue of steric hindrance in the substrate olefins. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.09.190