[(1S,2S,3R,4S,7R,9S,10S,12R,16R)-4,12-diacetyloxy-10,14,20,20-tetramethyl-11,15,18-trioxo-9-triethylsilyloxy-6,19-dioxapentacyclo[11.6.1.01,16.03,10.04,7]icos-13-en-2-yl] benzoate | 777950-68-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [(1S,2S,3R,4S,7R,9S,10S,12R,16R)-4,12-diacetyloxy-10,14,20,20-tetramethyl-11,15,18-trioxo-9-triethylsilyloxy-6,19-dioxapentacyclo[11.6.1.01,16.03,10.04,7]icos-13-en-2-yl] benzoate
• CAS: 777950-68-2
• 化学式: C₃₉H₅₀O₁₂Si
• 分子量: 738.904
• InChiKey: SMTYWRRDYKHJBK-RBPZGZSMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.07
• 重原子数：
  52
• 可旋转键数：
  12
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  158
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  [(1S,2S,3R,4S,7R,9S,10S,12R,16R)-4,12-diacetyloxy-10,14,20,20-tetramethyl-11,15,18-trioxo-9-triethylsilyloxy-6,19-dioxapentacyclo[11.6.1.01,16.03,10.04,7]icos-13-en-2-yl] benzoate 在 sodium tetrahydroborate 、 sodium hydrogen sulfate 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 5.5h， 生成 3-O-tert-butyl 5-O-[(1S,2S,3R,4S,7R,9S,10S,12R,15S,16S)-4,12-diacetyloxy-2-benzoyloxy-10,14,20,20-tetramethyl-11,18-dioxo-9-triethylsilyloxy-6,19-dioxapentacyclo[11.6.1.01,16.03,10.04,7]icos-13-en-15-yl] (4R,5R)-2-(2,4-dimethoxyphenyl)-4-(2-methylpropyl)-1,3-oxazolidine-3,5-dicarboxylate
  参考文献：
  名称：

  New Taxane Derivatives:  Synthesis of Baccatin[14,1-d]furan-2-one Nucleus and Its Condensation with the Norstatine Side Chain

  摘要：

  New taxanes 15 and 18, containing the unsaturated and saturated baccatin[14,1-d]furan-2-one nucleus, respectively, were prepared starting from the readily available 13-oxo-7-Tes-baccatin III (3). Sequential formation of the enolate of 3 and reaction with ethyl glyoxylate gave the 13-oxo-7-Tes-baccatin[14,1-d]-3,4-dehydrofuran-2-one 4. The reduction of 4 can result in the formation of a mixture of compounds corresponding to 13-hydroxy alcohol 5 and 13-enol derivative 6. Both 5 and 6 were transformed into 13-oxo-7-Tes-baccatin[14,1-d]furan-2-one 8 by treatment with a base. Further reduction of 8 gave 13-hydroxy compound 9. Esterification of 6 and 9 with NO-protected norstatine 12, followed by deprotection, gave the new promising anticancer taxanes 15 and 18, respectively.

  DOI：

  10.1021/jo0493018
• 作为产物：
  描述：

  [(1R,2S,3R,4S,7R,9S,10S,12R)-4,12-diacetyloxy-15-hydroxy-10,14,20,20-tetramethyl-11,18-dioxo-9-triethylsilyloxy-6,19-dioxapentacyclo[11.6.1.01,16.03,10.04,7]icosa-13,15-dien-2-yl] benzoate 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以90%的产率得到[(1S,2S,3R,4S,7R,9S,10S,12R,16R)-4,12-diacetyloxy-10,14,20,20-tetramethyl-11,15,18-trioxo-9-triethylsilyloxy-6,19-dioxapentacyclo[11.6.1.01,16.03,10.04,7]icos-13-en-2-yl] benzoate
  参考文献：
  名称：

  New Taxane Derivatives:  Synthesis of Baccatin[14,1-d]furan-2-one Nucleus and Its Condensation with the Norstatine Side Chain

  摘要：

  New taxanes 15 and 18, containing the unsaturated and saturated baccatin[14,1-d]furan-2-one nucleus, respectively, were prepared starting from the readily available 13-oxo-7-Tes-baccatin III (3). Sequential formation of the enolate of 3 and reaction with ethyl glyoxylate gave the 13-oxo-7-Tes-baccatin[14,1-d]-3,4-dehydrofuran-2-one 4. The reduction of 4 can result in the formation of a mixture of compounds corresponding to 13-hydroxy alcohol 5 and 13-enol derivative 6. Both 5 and 6 were transformed into 13-oxo-7-Tes-baccatin[14,1-d]furan-2-one 8 by treatment with a base. Further reduction of 8 gave 13-hydroxy compound 9. Esterification of 6 and 9 with NO-protected norstatine 12, followed by deprotection, gave the new promising anticancer taxanes 15 and 18, respectively.

  DOI：

  10.1021/jo0493018