(S)-1-(4-Carboxymethyl-2-methyl-oxazol-5-yl)-2,3-dihydro-1H-indole-2-carboxylic acid methyl ester | 160726-13-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-1-(4-Carboxymethyl-2-methyl-oxazol-5-yl)-2,3-dihydro-1H-indole-2-carboxylic acid methyl ester
• 英文别名: 2-[5-[(2S)-2-methoxycarbonyl-2,3-dihydroindol-1-yl]-2-methyl-1,3-oxazol-4-yl]acetic acid
• CAS: 160726-13-6
• 化学式: C₁₆H₁₆N₂O₅
• 分子量: 316.313
• InChiKey: VBHIRWCCKYJZPX-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  92.9
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (S)-1-(4-Carboxymethyl-2-methyl-oxazol-5-yl)-2,3-dihydro-1H-indole-2-carboxylic acid methyl ester 在 三氯化铝 、 草酰氯 作用下， 以 二氯甲烷 为溶剂， 生成 (S)-9-Methyl-6-oxo-1,2,6,7-tetrahydro-10-oxa-8,10b-diaza-benzo[cd]cyclopenta[h]azulene-1-carboxylic acid methyl ester
  参考文献：
  名称：

  Practical syntheses of a novel tricyclic dipeptide mimetic based on a [6H]-azepino indoline nucleus: Application to angiotensin-converting enzyme inhibition

  摘要：

  Two stereocontrolled synthetic approaches towards 5-(S)-amino-1,2,4,5,6,7-hexahydro-azepino [3,2,1-hi] indole-4-one-2-(S)-carboxylic acid 1, based on intramolecular Friedel-Crafts acylations, are reported. This conformationally restricted tricyclic dipeptidomimetic has been applied a the design of a potent and orally active inhibitor of angiotensin-converting enzyme (ACE).

  DOI：

  10.1016/s0040-4039(00)78331-6
• 作为产物：
  描述：

  (S)-1-((S)-2-Acetylamino-3-benzyloxycarbonyl-propionyl)-2,3-dihydro-1H-indole-2-carboxylic acid methyl ester 在 palladium on activated charcoal 氢气 、 三氯氧磷 作用下， 以 甲苯 为溶剂， 反应 2.0h， 生成 (S)-1-(4-Carboxymethyl-2-methyl-oxazol-5-yl)-2,3-dihydro-1H-indole-2-carboxylic acid methyl ester
  参考文献：
  名称：

  Practical syntheses of a novel tricyclic dipeptide mimetic based on a [6H]-azepino indoline nucleus: Application to angiotensin-converting enzyme inhibition

  摘要：

  Two stereocontrolled synthetic approaches towards 5-(S)-amino-1,2,4,5,6,7-hexahydro-azepino [3,2,1-hi] indole-4-one-2-(S)-carboxylic acid 1, based on intramolecular Friedel-Crafts acylations, are reported. This conformationally restricted tricyclic dipeptidomimetic has been applied a the design of a potent and orally active inhibitor of angiotensin-converting enzyme (ACE).

  DOI：

  10.1016/s0040-4039(00)78331-6

文献信息

• Practical syntheses of a novel tricyclic dipeptide mimetic based on a [6H]-azepino indoline nucleus: Application to angiotensin-converting enzyme inhibition
  作者：Stéphane De Lombaert、Louis Blanchard、Lisa B. Stamford、Donald M. Sperbeck、Michael D. Grim、Todd M. Jenson、Herman R. Rodriguez

  DOI：10.1016/s0040-4039(00)78331-6

  日期：1994.10

  Two stereocontrolled synthetic approaches towards 5-(S)-amino-1,2,4,5,6,7-hexahydro-azepino [3,2,1-hi] indole-4-one-2-(S)-carboxylic acid 1, based on intramolecular Friedel-Crafts acylations, are reported. This conformationally restricted tricyclic dipeptidomimetic has been applied a the design of a potent and orally active inhibitor of angiotensin-converting enzyme (ACE).