(S)-2-(phosphonomethyl)pentanedioic acid | 473251-81-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-(phosphonomethyl)pentanedioic acid
• 英文别名: 2-(phosphonomethyl)pentanedioic acid；(S)-2-PMPA；(2s)-2-(Phosphonomethyl)pentanedioic Acid
• CAS: 473251-81-9
• 化学式: C₆H₁₁O₇P
• 分子量: 226.123
• InChiKey: ISEYJGQFXSTPMQ-SCSAIBSYSA-N

物化性质

• 沸点：
  538.8±60.0 °C(Predicted)
• 密度：
  1.658±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  132
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (S)-2-(phosphonomethyl)pentanedioic acid dibenzyl ester 在 palladium on activated charcoal 氢气 作用下， 以 水 为溶剂， 反应 20.0h， 生成 (S)-2-(phosphonomethyl)pentanedioic acid
  参考文献：
  名称：

  Synthesis and biological evaluation of (R)- and (S)-2-(phosphonomethyl)pentanedioic acids as inhibitors of glutamate carboxypeptidase II

  摘要：

  Both enantiomers of 2-(phosphonomethyl)pentanedioic acid (2-PMPA), a potent and selective inhibitor of glutamate carboxypeptidase II (GCP II). were successfully prepared through the resolution of racemic 2-(hydroxyphosphinoylmethyl)pentanedioic acid dibenzyl ester with yohimbine and (S)-alpha-methylbenzylamine. The enantiomeric purity of the resolved phosphinic acid was measured by coupling it to (-)-menthol and analyzing the resulting ester by P-31 NMR. The absolute configuration of the 2-carbon atom in the resolved phosphinic acid was determined by X-ray crystallographic studies. Optically pure 2-PMPA was obtained by oxidation of the resolved phophinic acid to the phosphonic acid followed by catalytic hydrogenolysis. The biological activity of each enantiomer of 2-PMPA will also be described, (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(02)00412-3

文献信息

• [EN] DIAGNOSTIC DEVICE FOR THE DETECTION OF DISEASE RELATED TARGET STRUCTURES<br/>[FR] DISPOSITIF DIAGNOSTIQUE POUR LA DÉTECTION DE STRUCTURES CIBLES ASSOCIÉES À UNE MALADIE
  申请人：GILUPI GMBH

  公开号：WO2015028489A1

  公开（公告）日：2015-03-05

  The present invention provides a diagnostic device allowing highly specific and efficient in vivo and/or in vitro detection of a bio marker in a broad range of bodily fluids or tissues. The diagnostic device is composed of a binding agent that specifically binds a bio marker present in the bodily fluid linked by a linker compound or layer to the substrate, which includes a metallic, a semiconductor, or a polymeric carrier. The present invention further provides methods using said device for the detection of bio markers, as well as kits comprising said device and suitable ingredients for the detections of bio markers in a bodily fluid. Furthermore, the invention provides suitable in vivo and in vitro applications of said binding agent for the detection of specific disease-related target structures.

  本发明提供了一种诊断设备，允许在广泛范围的体液或组织中高度特异和高效地体内和/或体外检测生物标志物。该诊断设备由一个结合剂组成，该结合剂特异性地结合存在于体液中的生物标志物，通过连接剂化合物或层连接到基底上，该基底包括金属、半导体或聚合物载体。本发明还提供了使用该设备进行生物标志物检测的方法，以及包括该设备和适用于体液中生物标志物检测的合适成分的试剂盒。此外，该发明提供了适用于检测特定与疾病相关的靶标结构的结合剂的体内和体外应用。
• CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS
  申请人：ENDOCYTE, INC.

  公开号：US20150297735A1

  公开（公告）日：2015-10-22

  The invention described herein pertains to the diagnosis, imaging, and/or treatment of pathogenic cell populations. In particular, the invention described herein pertains to the diagnosis, imaging, and/or treatment of diseases caused by PSMA expressing cells, such as prostate cancer cells, using compounds capable of targeting PSMA expressing cells.

  本发明涉及对病原细胞群体的诊断、成像和/或治疗。特别地，本发明涉及使用能够靶向PSMA表达细胞的化合物，对由PSMA表达细胞引起的疾病，如前列腺癌细胞的诊断、成像和/或治疗。
• Diagnostic device for the detection of disease related target structures
  申请人：GILUPI GmbH

  公开号：EP2842578A1

  公开（公告）日：2015-03-04

  The present invention provides a diagnostic device allowing highly specific and efficient in vivo and/or in vitro detection of a bio marker in a broad range of bodily fluids or tissues. The diagnostic device is composed of a binding agent that specifically binds a bio marker present in the bodily fluid linked by a linker compound or layer to the substrate, which includes a metallic, a semiconductor, or a polymeric carrier. The present invention further provides methods using said device for the detection of bio markers, as well as kits comprising said device and suitable ingredients for the detections of bio markers in a bodily fluid. Furthermore, the invention provides suitable in vivo and in vitro applications of said binding agent for the detection of specific disease-related target structures.

  本发明提供了一种诊断装置，可在体内和/或体外高度特异、高效地检测各种体液或组织中的生物标记物。该诊断装置由一种结合剂组成，该结合剂可特异性地结合存在于体液中的生物标记物，并通过连接化合物或连接层与基底相连，基底包括金属、半导体或聚合物载体。本发明进一步提供了使用所述装置检测生物标记物的方法，以及包含所述装置和用于检测体液中生物标记物的适当成分的试剂盒。此外，本发明还提供了所述结合剂在体内和体外检测特定疾病相关目标结构的合适应用。
• DIAGNOSTIC DEVICE FOR THE DETECTION OF BIOMARKERS
  申请人：GILUPI GmbH

  公开号：EP2842578B1

  公开（公告）日：2018-06-27
• Diagnostic Device for the Detection of Disease Related Target Structures
  申请人：GILUPI GMBH

  公开号：US20160216257A1

  公开（公告）日：2016-07-28

  The present invention provides a diagnostic device allowing highly specific and efficient in vivo and/or in vitro detection of a bio marker in a broad range of bodily fluids or tissues. The diagnostic device is composed of a binding agent that specifically binds a bio marker present in the bodily fluid linked by a linker compound or layer to the substrate, which includes a metallic, a semiconductor, or a polymeric carrier. The present invention further provides methods using said device for the detection of bio markers, as well as kits comprising said device and suitable ingredients for the detections of bio markers in a bodily fluid. Furthermore, the invention provides suitable in vivo and in vitro applications of said binding agent for the detection of specific disease-related target structures.