N-Methyl-E-2-methoxyimino-2-[(2-methylphenyloxymethyl)phenyl]-acetamide | 156996-22-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Methyl-E-2-methoxyimino-2-[(2-methylphenyloxymethyl)phenyl]-acetamide
• 英文别名: E-2-methoxyimino-2-[(2-methylphenoxymethyl)phenyl]-N-methylacetamide；(2E)-2-methoxyimino-N-methyl-2-[2-[(2-methylphenoxy)methyl]phenyl]acetamide
• CAS: 156996-22-4
• 化学式: C₁₈H₂₀N₂O₃
• 分子量: 312.368
• InChiKey: RACRYYYCDCAZAL-LVZFUZTISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  59.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-Methyl-E-2-methoxyimino-2-[(2-methylphenyloxymethyl)phenyl]-acetamide 在 氢溴酸 作用下， 以 二氯甲烷 为溶剂， 生成 N-methyl (E)-2-methoxyimino-2-[2-(bromomethyl)phenyl]acetamide
  参考文献：
  名称：

  US6031110

  摘要：

  公开号：
• 作为产物：
  描述：

  醚菌酯 以 甲胺 为溶剂， 生成 N-Methyl-E-2-methoxyimino-2-[(2-methylphenyloxymethyl)phenyl]-acetamide
  参考文献：
  名称：

  2-(O-[pyrimidin-4-yl]methylenoxy)phenylacetic acid derivatives and their

  摘要：

  通式I中的2-(O-[嘧啶-4-基]甲氧基)苯乙酸衍生物及其盐和N-氧化物，其中基团R.sup.1至R.sup.4和Q的含义如下：R.sup.1是氢或烷基；R.sup.2是卤素，烷基或卤代烷基；R.sup.3是氢；氨基；羟基；巯基；卤素；未取代或苯基取代的烷基；卤代烷基；烷氧基烷基；烷氧基；单烷基氨基；二烷基氨基；烷基硫醇；烷基亚砜基；烷基磺酰基；环烷基；三烷基硅氧基，或：苯基，苯氧基，苯氧甲基，苄氧基或杂环基，在芳香环上未取代或取代；R.sup.4是氢；氰基；卤素；烷基；卤代烷基或烷氧基；Q是C（=NOCH.sub.3）-CONHCH.sub.3，C（=NOCH.sub.3）-COOCH.sub.3或N（OCH.sub.3）-COOCH.sub.3，其盐和N-氧化物，以及它们用于控制有害真菌和动物害虫。

  公开号：

  US06114342A1

文献信息

• Pyrazoyly derivatives and their use
  申请人：——

  公开号：US05506254A1

  公开（公告）日：1996-04-09

  Pyrazolyl derivatives of the general formula I ##STR1## where the indices and the substituents have the following meanings: n is is 0, 1, 2, 3 or 4, it being possible for the radicals R.sup.1 to be different if n is greater than 1; m is 0, 1 or 2, it being possible for the radicals R.sup.3 to be different if m is greater than 1; R.sup.1 is nitro, cyano, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio, unsubstituted or substituted phenyl or phenoxy; R.sup.2 is hydrogen, unsubstituted or substituted alkyl, alkenyl or alkynyl, an unsubstituted or substituted, saturated or mono- or diunsaturated ring, an unsubstituted or substituted, mono- or binuclear aromatic radical; R.sup.3 is nitro, cyano, halogen, alkyl, haloalkyl, alkoxy or haloalkoxy; R.sup.4 is hydrogen, cyano, halogen, alkyl or haloalkyl, processes for their preparation and their use are described.

  通式I的吡唑基衍生物 ##STR1## 其中指数和取代基的含义如下：n为0、1、2、3或4，如果n大于1，则基团R.sup.1可能不同；m为0、1或2，如果m大于1，则基团R.sup.3可能不同；R.sup.1为硝基、氰基、卤素、烷基、卤代烷基、烷氧基、卤代烷氧基或烷硫基，未取代或取代的苯基或苯氧基；R.sup.2为氢、未取代或取代的烷基、烯基或炔基、未取代或取代的饱和或单-或二不饱和环、未取代或取代的单核或双核芳基；R.sup.3为硝基、氰基、卤素、烷基、卤代烷基、烷氧基或卤代烷氧基；R.sup.4为氢、氰基、卤素、烷基或卤代烷基。描述了它们的制备过程及其用途。
• Ortho-substituted 2-methoxyiminophenyl-N-methylacetamides
  申请人：BASF Aktiengesellschaft

  公开号：US06605631B1

  公开（公告）日：2003-08-12

  Compounds of the general formula I where the index and the substituents have the following meanings: n is 0 or 1 to 4; X is O or S; Y is a five-membered heteroaromatic ring; R1 is nitro; cyano; halogen; alkyl; haloalkyl; alkoxy; haloalkoxy; alkylthio; phenyl or phenoxy; R2 is hydrogen; alkyl, alkenyl or alkynyl; or a saturatedy,or unsaturated ring which, in addition to carbon atoms, can also contain hetero atoms as ring members are described.

  描述了通式为I的化合物，其中指数和取代基的含义如下：n为0或1至4；X为O或S；Y为五元杂环芳香环；R1为硝基；氰基；卤素；烷基；卤代烷基；烷氧基；卤代烷氧基；烷硫基；苯基或苯氧基；R2为氢；烷基，烯基或炔基；或饱和或不饱和环，除了碳原子外，还可以包含杂原子作为环成员。
• 2-(0-(Pyrimidin-4-yl)methyleneoxy)phenylacetic acid derivatives and their use for controlling harmful fungi and animal pests
  申请人：BASF Aktiengesellschaft

  公开号：US06310071B1

  公开（公告）日：2001-10-30

  2-(O-[pyrimidin-4-yl]methylenoxy)phenylacetic acid derivatives of the general formula I and the salts and N-oxides thereof where the radicals R1 to R4 and Q have the following meanings: R1 is hydrogen or alkyl; R2 is halogen, alkyl or haloalkyl; R3 is hydrogen; amino; hydroxyl; mercapto; halogen; unsubstituted or phenyl-substituted alkyl; haloalkyl; alkoxyalkyl; alkoxy; monoalkylamino; dialkylamino; alkylthio; alkylsulfoxyl; alkylsulfonyl; cycloalkyl; trialkylsilyloxy, or: phenyl, phenoxy, phenoxymethyl, benzyloxy or hetaryl, unsubstituted or substituted in the aromatic ring; R4 is hydrogen; cyano; halogen; alkyl; haloalkyl or alkoxy; Q is C(═NOCH3)—CONHCH3, C(═NOCH3)—COOCH3 or N(OCH3)—COOCH3, the salts and N-oxides thereof, and their use for controlling harmful fungi and animal pests.

  一般式I的2-(O-[嘧啶-4-基]亚甲氧基)苯乙酸衍生物及其盐和N-氧化物，其中基团R1至R4和Q具有以下含义：R1为氢或烷基；R2为卤素、烷基或卤代烷基；R3为氢、氨基、羟基、巯基、卤素、未取代或苯基取代的烷基、卤代烷基、烷氧基烷基、烷氧基、单烷基氨基、双烷基氨基、烷基硫醇、烷基亚砜、烷基磺酰基、环烷基、三烷基硅氧基，或苯基、苯氧基、苯氧甲基、苄氧基或杂环基，在芳香环上未取代或取代；R4为氢、氰基、卤素、烷基、卤代烷基或烷氧基；Q为C（═NOCH3）—CONHCH3、C（═NOCH3）—COOCH3或N（OCH3）—COOCH3，其盐和N-氧化物，以及它们用于控制有害真菌和动物害虫。
• Process of producing N-alkylacetamides
  申请人：SHIONOGI & CO., LTD.

  公开号：EP0644183A2

  公开（公告）日：1995-03-22

  There is disclosed a process of producing an N-alkylacetamide of the general formula (III): wherein X1, X2 and X3 are the same or different and are independently hydrogen, lower alkyl, lower alkoxy, lower alkenyl, halogen or trifluoromethyl; R1 and R2 are the same or different and are independently lower alkyl; and represents a chemical bond of E- or Z-configuration, or a mixture of these configurations, which includes the steps of: (a) reacting an acetonitrile of the general formula (I): wherein X1, X2, X3, R1 and are each as defined above, with an alkylamine of the general formula (IV): wherein R2 is as defined above, to give an N-alkylacetamidine of the general formula (II): wherein X1, X2, X3, R1, R2 and are each as defined above; and (b) reacting the N-alkylacetamidine (II) with a nitrite derivative in the presence of an acid.

  本发明公开了一种通式（III）的 N-烷基乙酰胺的生产工艺： 其中 X1、X2 和 X3 相同或不同，且独立地为氢、低级烷基、低级烷氧基、低级烯基、卤素或三氟甲基；R1 和 R2 相同或不同，且独立地为低级烷基；代表 E- 或 Z-构型的化学键，或这些构型的混合物，该工艺包括以下步骤： (a) 使通式(I)的乙腈反应： 其中 X1、X2、X3、R1 和各如上定义，与通式（IV）的烷基胺反应： 其中 R2 如上定义，得到通式（II）的 N-烷基乙脒： 其中 X1、X2、X3、R1、R2 和各如上所定义；以及 (b) 在酸存在下，使 N-烷基乙脒（II）与亚硝酸盐衍生物反应。
• PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE
  申请人：SHIONOGI & CO., LTD.

  公开号：EP0658541A1

  公开（公告）日：1995-06-21

  A process for producing a carboxylic acid derivative represented by general formula [VIII], (wherein R¹, R², R³ and L are each as defined in the specification), which comprises reacting a benzyl halide with a cyano compound to give a phenylacetonitrile, reacting the nitrile with an alkyl nitrite in the presence of a base to give an α-hydroxyiminophenylacetonitrile, reacting the hydroxy nitrile with an alkylating agent to give an α-alkoxyiminophenylacetonitrile, hydrolyzing the alkoxy nitrile in the presence of a base, optionally after hydration and acid treatment, to give an α-alkoxyiminophenylacetic acid, and finally reacting the acid with a halogenating agent, or converting the acid into a corresponding metal salt and reacting the salt with an alkylating agent, or reacting the acid with a lower alcohol in the presence of an acidic catalyst. According to this process, the reactions can be advanced through the respective steps under mild conditions, and the target derivative [VIII] can be produced even without resort to high-pressure steam equipment, high-temperature heat medium equipment, refrigerator, and so forth. Further, this process is advantageous in that only a single solvent will suffice without the necessity for using various solvents according to the respective steps.

  一种生产通式[VIII]所代表的羧酸衍生物的工艺（其中R¹、R²、R³和L各自如说明书中所定义），该工艺包括将卤化苄基与氰基化合物反应，得到苯乙腈、在碱存在下，使腈与亚硝酸烷基酯反应，得到 α-羟基亚氨基苯乙腈，使羟基腈与烷化剂反应，得到 α-烷氧基亚氨基苯乙腈、在碱存在下，水解烷氧基腈（可选择在水合和酸处理后），得到 α-烷氧基亚氨基苯乙酸，最后使酸与卤化剂反应，或将酸转化为相应的金属盐并使盐与烷 化剂反应，或在酸性催化剂存在下使酸与低级醇反应。根据这种工艺，反应可以在温和的条件下通过相应的步骤进行，即使不使用高压蒸汽设备、高温热媒设备、冰箱等，也可以生产出目标衍生物[VIII]。此外，该工艺的优点还在于只需使用一种溶剂即可，而无需根据不同的步骤使用不同的溶剂。