(2R,4R)-3-Acetyl-2-(tert-butoxycarbonylamino-methyl)-thiazolidine-4-carboxylic acid methyl ester | 383177-03-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R,4R)-3-Acetyl-2-(tert-butoxycarbonylamino-methyl)-thiazolidine-4-carboxylic acid methyl ester
• 英文别名: methyl (2R,4R)-3-acetyl-2-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]-1,3-thiazolidine-4-carboxylate
• CAS: 383177-03-5
• 化学式: C₁₃H₂₂N₂O₅S
• 分子量: 318.394
• InChiKey: WNMICHYUICPVBA-VHSXEESVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2R,4R)-3-Acetyl-2-(tert-butoxycarbonylamino-methyl)-thiazolidine-4-carboxylic acid methyl ester 在 三氟乙酸 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.17h， 以65%的产率得到(1R,5R)-8-Acetyl-6-thia-3,8-diaza-bicyclo[3.2.1]octan-2-one
  参考文献：
  名称：

  Synthesis and Hybridization Properties of Thiazolidine PNAs

  摘要：

  Two new, constrained PNA monomers, each containing a thiazolidine ring, were synthesized and incorporated into a central position in a PNA. It was shown by UV melting experiments that the presence of a single constrained unit does not prevent the cooperative association of the PNA but does significantly destabilize PNA/DNA and PNA/RNA triplexes.

  DOI：

  10.1002/1099-0690(200109)2001:17<3285::aid-ejoc3285>3.0.co;2-v
• 作为产物：
  描述：

  N-叔丁氧羰基-2-氨基乙醛 在 吡啶 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 (2R,4R)-3-Acetyl-2-(tert-butoxycarbonylamino-methyl)-thiazolidine-4-carboxylic acid methyl ester
  参考文献：
  名称：

  Synthesis and Hybridization Properties of Thiazolidine PNAs

  摘要：

  Two new, constrained PNA monomers, each containing a thiazolidine ring, were synthesized and incorporated into a central position in a PNA. It was shown by UV melting experiments that the presence of a single constrained unit does not prevent the cooperative association of the PNA but does significantly destabilize PNA/DNA and PNA/RNA triplexes.

  DOI：

  10.1002/1099-0690(200109)2001:17<3285::aid-ejoc3285>3.0.co;2-v

文献信息

• Synthesis and Hybridization Properties of Thiazolidine PNAs
  作者：Sarah Bregant、Fabienne Burlina、Jacqueline Vaissermann、Gérard Chassaing

  DOI：10.1002/1099-0690(200109)2001:17<3285::aid-ejoc3285>3.0.co;2-v

  日期：2001.9

  Two new, constrained PNA monomers, each containing a thiazolidine ring, were synthesized and incorporated into a central position in a PNA. It was shown by UV melting experiments that the presence of a single constrained unit does not prevent the cooperative association of the PNA but does significantly destabilize PNA/DNA and PNA/RNA triplexes.

表征谱图