N-((R)-1-Hydroxymethyl-1-methyl-allyl)-benzamide | 160708-74-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-((R)-1-Hydroxymethyl-1-methyl-allyl)-benzamide
• 英文别名: N-[(2R)-1-hydroxy-2-methylbut-3-en-2-yl]benzamide
• CAS: 160708-74-7
• 化学式: C₁₂H₁₅NO₂
• 分子量: 205.257
• InChiKey: AVWJQLUGXWRZQN-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-((R)-1-Hydroxymethyl-1-methyl-allyl)-benzamide 在 sodium chlorite 、 sodium dihydrogenphosphate 、 重铬酸吡啶 作用下， 以 二氯甲烷 、 叔丁醇 为溶剂， 生成 (R)-2-Benzoylamino-2-methyl-but-3-enoic acid
  参考文献：
  名称：

  Enantiomerically enriched α-vinyl amino acids via lipase-mediated “reverse transesterification”

  摘要：

  Reduction of protected alpha-vinyl amino acids produces ''neopentyl'' alcohols that may be enriched in the L-antipode by lipase-mediated acylation with vinyl acetate. Subsequent deacetylation, oxidation and hydrolysis yields enantiomerically enriched L-alpha-vinyl amino acids.

  DOI：

  10.1016/s0040-4039(00)78486-3
• 作为产物：
  描述：

  (+/-)-N-benzoyl-α-vinylalaninol 生成 N-((R)-1-Hydroxymethyl-1-methyl-allyl)-benzamide
  参考文献：
  名称：

  Enantiomerically enriched α-vinyl amino acids via lipase-mediated “reverse transesterification”

  摘要：

  Reduction of protected alpha-vinyl amino acids produces ''neopentyl'' alcohols that may be enriched in the L-antipode by lipase-mediated acylation with vinyl acetate. Subsequent deacetylation, oxidation and hydrolysis yields enantiomerically enriched L-alpha-vinyl amino acids.

  DOI：

  10.1016/s0040-4039(00)78486-3

文献信息

• Enantiomerically enriched α-vinyl amino acids via lipase-mediated “reverse transesterification”
  作者：David B. Berkowitz、James A. Pumphrey、Quanrong Shen

  DOI：10.1016/s0040-4039(00)78486-3

  日期：1994.11

  Reduction of protected alpha-vinyl amino acids produces ''neopentyl'' alcohols that may be enriched in the L-antipode by lipase-mediated acylation with vinyl acetate. Subsequent deacetylation, oxidation and hydrolysis yields enantiomerically enriched L-alpha-vinyl amino acids.