N-(p-toluoyl)methionine | 121429-05-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(p-toluoyl)methionine
• 英文别名: methyl-N-(4-methylbenzoyl)homocysteine；2-[(4-methylbenzoyl)amino]-4-methylsulfanylbutanoic acid
• CAS: 121429-05-8
• 化学式: C₁₃H₁₇NO₃S
• mdl: MFCD09045445
• 分子量: 267.349
• InChiKey: ROAVZYTYQIFLQA-UHFFFAOYSA-N

物化性质

• 沸点：
  512.8±50.0 °C(Predicted)
• 密度：
  1.209±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.384
• 拓扑面积：
  91.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(p-toluoyl)methionine 在 2-氯-1,3-二甲基氯化咪唑啉 、 三乙胺 作用下， 以 1,2-二氯乙烷 为溶剂， 以31%的产率得到4-(2-Methylsulfanyl-ethyl)-2-p-tolyl-4H-oxazol-5-one
  参考文献：
  名称：

  2-Chloro-1,3-dimethylimidazolinium Chloride. 2. Its Application to the Construction of Heterocycles through Dehydration Reactions

  摘要：

  2-Chloro-1,3-dimethylimidazolinium chloride (DMC) (1) can act as a powerful dehydrating equivalent to DCC (2) under nearly neutral conditions. Its application to the construction of heterocycles through dehydration reactions is described.

  DOI：

  10.1021/jo9909756
• 作为产物：
  描述：

  对甲基苯甲酰氯 、 4-Methyl-N-[3-methylsulfanyl-1-(quinolin-8-ylcarbamoyl)-propyl]-benzamide 生成 N-(p-toluoyl)methionine
  参考文献：
  名称：

  具有 8-喹啉基的甲硫氨酸二酰胺衍生物通过液膜有效传输 Hg(II) 离子

  摘要：

  以蛋氨酸为原料合成了几种具有 8-喹啉基的新型二酰胺化合物，并研究了它们作为载体通过液膜的金属离子传输能力。Hg(II) 离子被这些载体最有效地运输。通过在 2-酰基氨基取代基上引入庞大的对甲苯酰基作为酰基，提高了 Hg(II) 对 Cu(II) 的选择性。

  DOI：

  10.1246/cl.1993.2183

文献信息

• Melanogenesis inhibitor comprising d-pantothenyl alcohol, and skin-whitening cosmetic containing same melanogenesis inhibitor
  申请人：POLA CHEMICAL INDUSTRIES, INC.

  公开号：US10568822B2

  公开（公告）日：2020-02-25

  Provided is a new application for D-pantothenyl alcohol. It is a melanogenesis inhibitor comprising D-pantothenyl alcohol.

  本文提供了一种 D-泛醇的新应用。它是一种含有 D-泛醇的黑色素生成抑制剂。
• Composition containing a penem or carbapenem antibiotic
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0226304B1

  公开（公告）日：1991-08-28
• ANTI-WRINKLE AGENTS
  申请人：Suenobu Noriko

  公开号：US20110245343A1

  公开（公告）日：2011-10-06

  Provided are anti-wrinkle agents having a novel scaffold that is suitable as components for external skin preparations such as cosmetics. The anti-wrinkle agents comprise compounds represented by general formula (1), stereoisomers thereof, or pharmacologically acceptable salts thereof. Said anti-wrinkle agents have excellent efficacy in improving wrinkles and sagging that are caused by skin aging with increased age or occur as a result of photoaging due to ultraviolet rays exposure. [In the formula, R 1 represents a hydrogen atom or a 1 to 8 carbon straight or branched alkyl group. R 2 represents —SH, —SO 3 H, —S—S—X 1 , —S—X 2 , —SO—X 3 , —SO 2 —X 4 , —SO 2 —NY 1 —X 5 or —SO 2 —NY 2 —Y 3 . X 1 -X 5 independently are hydrogen atoms or 1 to 8 carbon aliphatic hydrocarbon groups or 5 to 12 carbon aromatic moiety wherein carbon atoms may be substituted with heteroatoms. Y 1 to Y 3 independently represent hydrogen atoms or 1 to 8 carbon linear or branched alkyl groups. R 3 represents a hydrogen atom or acyl group having a 1 to 8 carbon straight or branched alkyl chain. R 4 represents a 5 to 12 carbon aromatic group or polycyclic condensed aromatic group that may have unsubstituted or substituted groups. m represents an integer 0-3 and n represents an integer 1 or 2.]
• MELANOGENESIS INHIBITOR COMPRISING D-PANTOTHENYL ALCOHOL, AND SKIN-WHITENING COSMETIC CONTAINING SAME MELANOGENESIS INHIBITOR
  申请人：POLA CHEMICAL INDUSTRIES, INC.

  公开号：US20170119638A1

  公开（公告）日：2017-05-04

  Provided is a new application for D-pantothenyl alcohol. It is a melanogenesis inhibitor comprising D-pantothenyl alcohol.
• US4757066A
  申请人：——

  公开号：US4757066A

  公开（公告）日：1988-07-12