N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal | 167498-29-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal
• 英文别名: Z-FY-Cho；benzyl N-[(2S)-1-[[(2S)-1-(4-hydroxyphenyl)-3-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
• CAS: 167498-29-5
• 化学式: C₂₆H₂₆N₂O₅
• 分子量: 446.503
• InChiKey: QVDJMLQSYRSZKC-UPVQGACJSA-N

物化性质

• 沸点：
  726.5±60.0 °C(Predicted)
• 密度：
  1.249±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（高达30mg/ml）或乙醇（高达50mg/ml）

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  {(S)-1-[(S)-2-(4-Hydroxy-phenyl)-1-(3-methyl-thiazolidin-2-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester 在 水 、 copper(II) oxide 、 copper dichloride 作用下， 以 乙腈 为溶剂， 生成 N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal
  参考文献：
  名称：

  Synthesis of Peptidyl Aldehydes from Thiazolidines

  摘要：

  Peptidyl aldehydes were synthesized using thiazolidine peptides as precursors. Hydrolysis of the heterocycles is easily accomplished using cupper salts to furnish the peptidyl aldehydes with very good yield and with no epimerization. (C) 1997 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00383-3

文献信息

• Compounds, compositions and methods for treatment of parasitic infections
  申请人：——

  公开号：US20020107266A1

  公开（公告）日：2002-08-08

  Compounds and pharmaceutical compositions useful as anti-parasitic agents agents, particularly in the treatment, prevention or amelioration of one or more symptoms of malaria or Chagas' disease, are provided. In particular, methods of modulating the activity of falcipain or cruzain, preferably inhibiting falcipain or cruzain, with the compounds and compositions are provided.

  提供了作为抗寄生虫药剂的化合物和药物组合物，特别是用于治疗、预防或缓解疟疾或充满病症状之一的药剂。具体而言，提供了利用这些化合物和组合物调节falcipain或cruzain活性的方法，优选抑制falcipain或cruzain的方法。
• DIPEPTIDYL ALDEHYDES FOR THE TREATMENT AND/OR PREVENTION OF PARASITIC DISEASES
  申请人：Axiava Pharma UG

  公开号：EP3413977A1

  公开（公告）日：2018-12-19
• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF PARASITIC INFECTIONS<br/>[FR] COMPOSES, COMPOSITIONS ET PROCEDES DE TRAITEMENT D'INFECTIONS PARASITAIRES
  申请人：——

  公开号：WO2002048097A9

  公开（公告）日：2003-05-08

  [EN] Compounds and pharmaceutical compositions useful as anti-parasitic agents, particularly in the treatment, prevention or amelioration of one or more symptoms of malaria or Chagas' disease, are provided. In particular, methods of modulating the activity of falcipain or cruzain, preferably inhibiting falcipain or cruzain, with the compounds and compositions are provided.
  [FR] L'invention concerne des composés et des compositions pharmaceutiques utiles comme agents anti-parasitaires, notamment dans le traitement, la prévention ou l'amélioration d'au moins un symptôme du paludisme ou de la maladie de Chaga. L'invention concerne plus précisément des procédés de modulation de l'activité du falcipain ou du cruzain et, de préférence, d'inhibition du falcipain ou du cruzain, par lesdits composés et compositions.
• [EN] DIPEPTIDYL ALDEHYDES FOR THE TREATMENT AND/OR PREVENTION OF PARASITIC DISEASES<br/>[FR] DIPEPTIDYL ALDÉHYDES POUR LE TRAITEMENT ET/OU LA PRÉVENTION DE MALADIES PARASITAIRES
  申请人：AXIAVA PHARMA UG

  公开号：WO2017137448A1

  公开（公告）日：2017-08-17

  Several parasites responsible for mammalian diseases are dependent on cysteine proteases for various life-cycle functions. Inhibition or decreasing function of specific cysteine proteases can be useful in the treatment and/or prevention of these parasitic diseases including trichomoniasis, histomoniasis, coccidiosis, trypanosomiasis (trypamonosis) and cryptosporidiosis. Compounds of formula I of the invention are capable of treating and/or preventing the above-identified diseases in mammals, e.g. in avian species as Galliformes including chickens, turkeys, ducks, geese, grouse, guinea fowl, peafowl, quail, partridges, and pheasants, Falconiformes, Passiformes, Columbiformes (i.e. Columba livia domestica), Psittaciformes, and in domestic mammals such as cattle, sheep, goats, horses, pigs, camels, lamas, alpacas, cats and dogs.