(S)-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N6-(5-isopropoxy-1H-pyrazol-3-yl)pyrazine-2,6-diamine | 1065331-77-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (S)-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N6-(5-isopropoxy-1H-pyrazol-3-yl)pyrazine-2,6-diamine
• 英文别名: 2-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-6-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrazine-2,6-diamine
• CAS: 1065331-77-2
• 化学式: C₁₇H₂₀FN₇O
• 分子量: 357.391
• InChiKey: NGMZLWDETZHMAI-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  tert-butyl 3-amino-5-isopropoxy-1H-pyrazole-1-carboxylate 、 6-chloro-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]pyrazin-2-amine 在 tris-(dibenzylideneacetone)dipalladium(0) 、 caesium carbonate 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 1,4-二氧六环 为溶剂， 生成 (S)-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N6-(5-isopropoxy-1H-pyrazol-3-yl)pyrazine-2,6-diamine
  参考文献：
  名称：

  Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors

  摘要：

  The design, synthesis and biological evaluation of a series of pyrazol-3-ylamino pyrazines as potent and selective JAK2 kinase inhibitors is reported, along with the pharmacokinetic and pharmacodynamic properties of lead compounds. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.054

文献信息

• Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors
  作者：Stephanos Ioannidis、Michelle L. Lamb、Audrey M. Davies、Lynsie Almeida、Mei Su、Geraldine Bebernitz、Minwei Ye、Kirsten Bell、Marat Alimzhanov、Michael Zinda

  DOI：10.1016/j.bmcl.2009.10.054

  日期：2009.12

  The design, synthesis and biological evaluation of a series of pyrazol-3-ylamino pyrazines as potent and selective JAK2 kinase inhibitors is reported, along with the pharmacokinetic and pharmacodynamic properties of lead compounds. (C) 2009 Elsevier Ltd. All rights reserved.