3-{N-[(ethoxycarbonyl)methyl]-N-methylamino}propylamine | 289701-07-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-{N-[(ethoxycarbonyl)methyl]-N-methylamino}propylamine
• 英文别名: ethyl 2-[3-aminopropyl(methyl)amino]acetate
• CAS: 289701-07-1
• 化学式: C₈H₁₈N₂O₂
• 分子量: 174.243
• InChiKey: PKRHKOHFXJRGKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-{N-[(ethoxycarbonyl)methyl]-N-methylamino}propylamine 、 4-[(3-bromophenyl)amino]-6-{[(2-carboxyvinyl)carbonyl]amino}-quinazoline 在 1-羟基苯并三唑 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.33h， 以39%的产率得到4-[(3-bromophenyl)amino]-6-{[4-(3-{N-[(ethoxycarbonyl)methyl]-N-methylamino}propylamino)-1,4-dioxo-2-buten-1-yl]amino}-quinazoline
  参考文献：
  名称：

  4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases

  摘要：

  本发明涉及具有一般公式二环杂环化合物，其中R a 至R d ，A至G和X定义如权利要求1所述，包括其互变异构体、立体异构体及盐，特别是具有有价值的药理性质、特别是对由酪氨酸激酶介导的信号转导具有抑制效果的、与无机或有机酸或碱形成的生理可接受盐，用于治疗疾病，特别是肿瘤疾病、肺和呼吸道疾病，及其制备方法。

  公开号：

  US06972288B1

文献信息

• 4-amino- quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases
  申请人：Boehringer Ingelheim Pharma GmbH & Co. KG

  公开号：EP2298746A1

  公开（公告）日：2011-03-23

  The present invention relates to bicyclic heterocycles of general formula wherein Ra to Rd, A to G and X are defined as in claim 1, the tautomers, the stereoisomers and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibiting effect on signal transduction mediated by tyrosine kinases, their use for treating diseases, particularly tumoral diseases, diseases of the lungs and respiratory tract, and the preparation thereof.

  本发明涉及通式如下的双环杂环 其中 Ra 至 Rd、A 至 G 和 X 的定义如权利要求 1 所述；它们的同分异构体、立体异构体和盐，特别是它们与无机酸或有机酸或碱的生理上可接受的盐，这些盐具有重要的药理特性，特别是对酪氨酸激酶介导的信号转导有抑制作用；它们可用于治疗疾病，特别是肿瘤疾病、肺部和呼吸道疾病；以及它们的制备方法。
• 4-AMINO- QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES
  申请人：Boehringer Ingelheim Pharma KG

  公开号：EP1157011A1

  公开（公告）日：2001-11-28
• US6972288B1
  申请人：——

  公开号：US6972288B1

  公开（公告）日：2005-12-06
• [EN] 4-AMINO-QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANsSDUCTION MEDIATED BY TYROSINE KINASES<br/>[FR] DERIVES DE 4-AMINO-QUINAZOLINE ET DE QUINOLINE AYANT UN EFFET INHIBITEUR SUR LA TRANSDUCTION DE SIGNAL PAR LES TYROSINE KINASES
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2000051991A1

  公开（公告）日：2000-09-08

  The present invention relates to bicyclic heterocycles of general formula (I), wherein Ra to Rd, A to G and X are defined as in claim 1, the tautomers, the stereoisomers and the salts thereof, particularly the physiologically acceptable salts thereof particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibiting effect on signal transduction mediated by tyrosine kinases, their use for treating diseases, particularly tumoral diseases, diseases of the lungs and respiratory tract, and the preparation thereof.
• 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases
  申请人：Himmelsbach Frank

  公开号：US06972288B1

  公开（公告）日：2005-12-06

  The present invention relates to bicyclic heterocycles of general formula wherein R a to R d , A to G and X are defined as in claim 1, the tautomers, the steroisomers and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibiting effect on signal transduction mediated by tyrosine kinases, their use for treating diseases, particularly tumoral diseases, diseases of the lungs and respiratory tract, and the preparation thereof.

  本发明涉及具有一般公式二环杂环化合物，其中R a 至R d ，A至G和X定义如权利要求1所述，包括其互变异构体、立体异构体及盐，特别是具有有价值的药理性质、特别是对由酪氨酸激酶介导的信号转导具有抑制效果的、与无机或有机酸或碱形成的生理可接受盐，用于治疗疾病，特别是肿瘤疾病、肺和呼吸道疾病，及其制备方法。