N-(2,2-diethoxyethyl)butyramide | 1354282-24-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(2,2-diethoxyethyl)butyramide
• 英文别名: N-(2,2-diethoxyethyl)butanamide
• CAS: 1354282-24-8
• 化学式: C₁₀H₂₁NO₃
• 分子量: 203.282
• InChiKey: UUNZUCVGORXWPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2,2-diethoxyethyl)butyramide 在 盐酸 、 水 作用下， 以 四氢呋喃 、 乙醚 、 乙醇 为溶剂， 反应 21.0h， 生成 N-(2-((1-(1-(3,4-dichlorophenyl)cyclobutyl)-3-methylbutyl)amino)ethyl)butyramide
  参考文献：
  名称：

  Compositions, Synthesis, and Methods of Using Cycloalkylmethylamine Derivatives

  摘要：

  本发明提供了新颖的环烷基甲胺衍生物，以及制备环烷基甲胺衍生物的方法。本发明还提供了使用环烷基甲胺衍生物和环烷基甲胺衍生物组合物的方法。本发明化合物的药物组合物可优势用于治疗和/或预防肥胖及与肥胖相关的共病症和抑郁症及与抑郁症相关的共病症。

  公开号：

  US20120172426A1

文献信息

• METHODS OF USING CYCLOALKYLMETHYLAMINE DERIVATIVES
  申请人：Reviva Pharmaceuticals, Inc.

  公开号：US20140024709A1

  公开（公告）日：2014-01-23

  The present invention provides novel cycloalkylmethylamine derivatives, and methods of preparing cycloalkylmethylamine derivatives. The present invention also provides methods of using cycloalkylmethylamine derivatives and compositions of cycloalkylmethylamine derivatives. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications and depression and depression related co-morbid indications.

  本发明提供了新型环烷基甲胺衍生物及其制备方法。本发明还提供了使用环烷基甲胺衍生物的方法和环烷基甲胺衍生物的组合物。本发明化合物的制药组合物可以优势地用于治疗和/或预防肥胖和肥胖相关的共病症以及抑郁症和抑郁症相关的共病症。
• Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives
  申请人：Bhat Laxminarayan

  公开号：US08604244B2

  公开（公告）日：2013-12-10

  The present invention provides novel cycloalkylmethylamine derivatives, and methods of preparing cycloalkylmethylamine derivatives. The present invention also provides methods of using cycloalkylmethylamine derivatives and compositions of cycloalkylmethylamine derivatives. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications and depression and depression related co-morbid indications.

  本发明提供了新型环烷基甲基胺衍生物以及制备环烷基甲基胺衍生物的方法。本发明还提供了使用环烷基甲基胺衍生物的方法和环烷基甲基胺衍生物的组合物。本发明化合物的制药组合物可优势地用于治疗和/或预防肥胖和肥胖相关的共病症以及抑郁症和抑郁症相关的共病症。
• CYCLOALKYLMETHYLAMINES
  申请人：Reviva Pharmaceuticals, Inc.

  公开号：US20140066500A1

  公开（公告）日：2014-03-06

  The present invention provides novel cycloalkylmethylamine derivatives, and methods of preparing cycloalkylmethylamine derivatives. The present invention also provides methods of using cycloalkylmethylamine derivatives and compositions of cycloalkylmethylamine derivatives. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications and depression and depression related co-morbid indications.

  本发明提供了新型环烷基甲基胺衍生物，以及制备环烷基甲基胺衍生物的方法。本发明还提供了使用环烷基甲基胺衍生物的方法和环烷基甲基胺衍生物的组成物。本发明化合物的制药组合物可以优势地用于治疗和/或预防肥胖和肥胖相关的并发症和抑郁症以及抑郁症相关的并发症。
• Methods of using cycloalkylmethylamine derivatives
  申请人：Reviva Pharmaceuticals, Inc.

  公开号：US09096515B2

  公开（公告）日：2015-08-04

  The present invention provides novel cycloalkylmethylamine derivatives, and methods of preparing cycloalkylmethylamine derivatives. The present invention also provides methods of using cycloalkylmethylamine derivatives and compositions of cycloalkylmethylamine derivatives. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications and depression and depression related co-morbid indications.

  本发明提供了新型环烷基甲基胺衍生物及其制备方法。本发明还提供了使用环烷基甲基胺衍生物的方法和环烷基甲基胺衍生物的组合物。本发明所述化合物的制药组合物可用于有利地治疗和/或预防肥胖和肥胖相关的共病症以及抑郁症和抑郁症相关的共病症。
• Cycloalkylmethylamines
  申请人：Reviva Pharmaceuticals, Inc.

  公开号：US09296681B2

  公开（公告）日：2016-03-29

  The present invention provides novel cycloalkylmethylamine derivatives, and methods of preparing cycloalkylmethylamine derivatives. The present invention also provides methods of using cycloalkylmethylamine derivatives and compositions of cycloalkylmethylamine derivatives. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications and depression and depression related co-morbid indications.

  本发明提供了新型环烷基甲基胺衍生物，以及制备环烷基甲基胺衍生物的方法。本发明还提供了使用环烷基甲基胺衍生物的方法和环烷基甲基胺衍生物的组合物。本发明化合物的药物组合物可以优势地用于治疗和/或预防肥胖和肥胖相关的共病指标以及抑郁症和抑郁症相关的共病指标。