1-Methyl-4,4-bis-ethoxycarbonylmethyl-piperidin | 92329-92-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-Methyl-4,4-bis-ethoxycarbonylmethyl-piperidin
• 英文别名: (1-methyl-piperidine-4,4-diyl)-di-acetic acid diethyl ester；(1-Methyl-piperidin-4,4-diyl)-di-essigsaeure-diaethylester；Diethyl 2,2'-(1-methylpiperidine-4,4-diyl)diacetate；ethyl 2-[4-(2-ethoxy-2-oxoethyl)-1-methylpiperidin-4-yl]acetate
• CAS: 92329-92-5
• 化学式: C₁₄H₂₅NO₄
• 分子量: 271.357
• InChiKey: QZUULGDOYQFDQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-Methyl-4,4-bis-ethoxycarbonylmethyl-piperidin 、 苄胺 以95%的产率得到3-benzyl-9-methyl-3,9-diaza-spiro[5.5]undecane-2,4-dione
  参考文献：
  名称：

  Practical and divergent synthesis of 1- and 5-substituted 3,9-diazaspiro[5.5]undecanes and undecan-2-ones

  摘要：

  A divergent synthesis of 1- and 5-substituted 3,9-diazaspiro[5.5]undecanes and undecan-2-ones is described, in which the key step is an efficient Michael addition of a lithium enolate to a tetrasubstituted olefin acceptor. A variety of substituents (butyl, phenyl,and propoxyl)were introduced at C-1(5) in this manner. in addition, an asymmetric synthesis of one member of this series was achieved using an Evans oxazolidinone chiral auxiliary reagent. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.08.086
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 硫酸 作用下， 生成 1-Methyl-4,4-bis-ethoxycarbonylmethyl-piperidin
  参考文献：
  名称：

  Piperidine Derivatives. XXII. The Condensation of 1-Methyl-4-piperidone with Active Methylene Compounds

  摘要：

  DOI：

  10.1021/ja01157a104