2-((E)-3-Hydroxy-4-methyl-oct-1-enyl)-cyclopropane-1,1-dicarboxylic acid diethyl ester | 55309-82-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-((E)-3-Hydroxy-4-methyl-oct-1-enyl)-cyclopropane-1,1-dicarboxylic acid diethyl ester
• 英文别名: Diethyl trans-2-(3-hydroxy-4-methyl-1-octenyl)cyclopropane-1,1-dicarboxylate；diethyl 2-[(E)-3-hydroxy-4-methyloct-1-enyl]cyclopropane-1,1-dicarboxylate
• CAS: 55309-82-5
• 化学式: C₁₈H₃₀O₅
• 分子量: 326.433
• InChiKey: PEVWOXOTAMJHMF-ZHACJKMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  、 Diethyl trans-2-(3-hydroxy-3methyl-1-octenyl)cyclopropane-1,1-dicarboxylate 、 2-(四氢-2H-吡喃-2-基氧基)-四氢-2H-吡喃 、 2-((E)-3-Hydroxy-4-methyl-oct-1-enyl)-cyclopropane-1,1-dicarboxylic acid diethyl ester 以gives diethyl trans-2-{3-[(tetrahydropyran-2-yl)oxy]-4-methyl-1-octenyl}-cyclopropane-1,1-dicarboxylate, νmax film 1035, 1140, 1220 cm-1, and dimethyl trans-2-(4-ethyl-3-hydroxy-1-decenyl)cyclopropane-1,1-dicarboxylate的产率得到Diethyl trans-2-{3-[(tetrahydropyran-2-yl)oxy]-4-methyl-1-octenyl}cyclopropane-1,1-dicarboxylate
  参考文献：
  名称：

  Prostaglandin intermediate

  摘要：

  化学式为##SPC1##的前列腺素衍生物被披露，其中R.sup.4、R.sup.5、R.sup.6和R.sup.7分别是氢或低烷基，X是羟基，Y是氢或X和Y在一起是氧，Z是CH.sub.2 CH.sub.2或反式CH=CH，m是从一到三的整数，n是从二到五的整数，但至少有一个R.sup.4、R.sup.5或R.sup.6是氢。同时还披露了它们的制备方法。其中Z为CH.sub.2 CH.sub.2的化合物和制备方法是新的。这些新衍生物具有降压、抗高血压、支气管痉挛解除、抑制胃酸分泌、引产、发情同步和促进排卵的作用。这些化合物还能抑制血小板聚集并促进聚集的血小板解聚。还披露了它们的使用方法。

  公开号：

  US03959263A1

文献信息

• Alkyl derivatives of prostanoic acids and preparation thereof
  申请人：American Home Products Corporation

  公开号：US03987081A1

  公开（公告）日：1976-10-19

  15- And/or 16-alkyl derivatives of 9,15-dioxygenated prost-13-enoic, prosta-4,13-dienoic and prosta-5,13-dienoic acid, lower alkyl esters thereof and homologs thereof, as well as a process for preparing these derivatives are disclosed. The compounds possess hypotensive, antihypertensive, bronchospasmolytic, gastric acid secretion inhibiting, abortifacient, estrus synchronizing and ovulation regulating properties. The compounds also inhibit the aggregation of platelets and promote the disaggregation of aggregated platelets. Methods for their use are also disclosed.

  本文介绍了9,15-二氧代前列腺-13-烯酸、前列腺-4,13-二烯酸和前列腺-5,13-二烯酸的15-和/或16-烷基衍生物、其较低的烷基酯和同系物，以及制备这些衍生物的方法。这些化合物具有降压、抗高血压、支气管痉挛解除、抑制胃酸分泌、引产、发情同步和排卵调节的特性。这些化合物还能抑制血小板的聚集并促进已聚集的血小板的分散。本文还介绍了它们的使用方法。
• Intermediates for prostanoic acids
  申请人：American Home Products Corporation

  公开号：US04007171A1

  公开（公告）日：1977-02-08

  15- And/or 16-alkyl derivatives of 9,15-dioxygenated prost-13-enoic, prosta-4,13-dienoic and prosta-5,13-dienoic acid, lower alkyl esters thereof and homologs thereof, as well as a process for preparing these derivatives are disclosed. The compounds possess hypotensive, antihypertensive, bronchospasmolytic, gastric acid secretion inhibiting, abortifacient, estrus synchronizing and ovulation regulating properties. The compounds also inhibit the aggregation of platelets and promote the disaggregation of aggregated platelets. Methods for their use are also disclosed.

  本文披露了9,15-二氧代前列腺-13-烯酸、前列腺-4,13-二烯酸和前列腺-5,13-二烯酸的15-和/或16-烷基衍生物，以及其较低的烷基酯和同系物，以及制备这些衍生物的方法。这些化合物具有降压、抗高血压、支气管痉挛解除、抑制胃酸分泌、引产、发情同步和促排卵的特性。这些化合物还能抑制血小板聚集并促进聚集血小板的解聚。同时，本文还披露了它们的使用方法。
• Alkyl derivatives of 4,5-dehydro PGE.sub.1
  申请人：American Home Products Corporation

  公开号：US04048329A1

  公开（公告）日：1977-09-13

  15- And/or 16-alkyl derivatives of 9,15-dioxygenated prost-13-enoic, prosta-4,13-dienoic and prosta-5,13-dienoic acid, lower alkyl esters thereof and homologs thereof, as well as a process for preparing these derivatives are disclosed. The compounds possses hypotensive, antihypertensive, bronchospasmolytic, gastric acid secretion inhibiting, abortifacient, estrus synchronizing and ovulation regulating properties. The compounds also inhibit the aggregation of platelets and promote the disaggregation of aggregated platelets. Methods for their use are also disclosed.

  本文介绍了9,15-二氧代前列腺-13-烯酸、前列腺-4,13-二烯酸和前列腺-5,13-二烯酸的15-和/或16-烷基衍生物、其低烷基酯和同系物，以及制备这些衍生物的方法。这些化合物具有降压、抗高血压、支气管痉挛解除、抑制胃酸分泌、引产、发情同步和促排卵等性质。这些化合物还可以抑制血小板聚集并促进已聚集的血小板解聚。本文还介绍了它们的使用方法。
• Alkyl derivatives of 4,5-dehydro PGF.sub.1
  申请人：American Home Products Corporation

  公开号：US04048328A1

  公开（公告）日：1977-09-13

  15- And/or 16-alkyl derivatives of 9,15-dioxygenated prost-13-enoic, prosta-4,13-dienoic and prosta-5,13-dienoic acid, lower alkyl esters thereof and homologs thereof, as well as a process for preparing these derivatives are disclosed. The compounds possess hypotensive, anti-hypertensive, bronchospasmolytic, gastric acid secretion inhibiting, abortifacient, estrus synchronizing and ovulation regulating properties. The compounds also inhibit the aggregation of platelets and promote the disaggregation of aggregated platelets. Methods for their use are also disclosed.

  本发明公开了9,15-二氧代前列腺-13-烯酸、前列腺-4,13-二烯酸和前列腺-5,13-二烯酸的15-和/或16-烷基衍生物，以及它们的低碳酸酯和同系物的制备方法。这些化合物具有降压、抗高血压、支气管痉挛解除、抑制胃酸分泌、引产、发情同步和排卵调节作用。这些化合物还能抑制血小板聚集并促进已聚集血小板的解聚。本发明还公开了它们的使用方法。
• Method of inducing abortion using alkyl derivatives of prostanoic acids
  申请人：American Home Products Corporation

  公开号：US04092427A1

  公开（公告）日：1978-05-30

  15- And/or 16-alkyl derivatives of 9,15-dioxygenated prost-13-enoic, prosta-4,13-dienoic and prosta-5,13-dienoic acid, lower alkyl esters thereof and homologs thereof, as well as a process for preparing these derivatives are disclosed. The compounds possess hypotensive, anti-hypertensive, bronchospasmolytic, gastric acid secretion inhibiting, abortifacient, estrus synchronizing and ovulation regulating properties. The compounds also inhibit the aggregation of platelets and promote the disaggregation of aggregated platelets. Methods for their use are also disclosed.

  本发明公开了9,15-二氧代前列腺-13-烯酸、前列腺-4,13-二烯酸和前列腺-5,13-二烯酸的15-和/或16-烷基衍生物，以及其较低烷基酯和同源物，以及制备这些衍生物的方法。这些化合物具有降压、抗高血压、支气管痉挛松弛、抑制胃酸分泌、流产、发情同步和排卵调节作用。这些化合物还能抑制血小板聚集并促进已聚集的血小板解聚。本发明还公开了它们的使用方法。