(Z)-1-(4-bromophenyl)-3-(2-chlorobenzylidene)-4-phenylazetidin-2-one | 1125691-45-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: (Z)-1-(4-bromophenyl)-3-(2-chlorobenzylidene)-4-phenylazetidin-2-one
• 英文别名: (3Z)-1-(4-bromophenyl)-3-[(2-chlorophenyl)methylidene]-4-phenylazetidin-2-one
• CAS: 1125691-45-3
• 化学式: C₂₂H₁₅BrClNO
• 分子量: 424.724
• InChiKey: MNDKZWLFMMOWAR-RGEXLXHISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-氯苯甲醛 、 cis-1-(4-bromophenyl)-4-phenyl-3-(trimethylsilyl)azetidin-2-one 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 生成 (E)-1-(4-bromophenyl)-3-(2-chlorobenzylidene)-4-phenylazetidin-2-one 、 (Z)-1-(4-bromophenyl)-3-(2-chlorobenzylidene)-4-phenylazetidin-2-one
  参考文献：
  名称：

  β-Lactam derivatives as potential anti-cancer compounds

  摘要：

  A number of 1,4-diaryl-3-methylene substituted beta-lactams, the addition products obtained from their reactions with N-, S-, and C-nucleophiles, and diverse related compounds were prepared, and a selection of 43 compounds was screened in preliminary tests as anti-tumor compounds by using 4 or 5 human cancer cell lines of diverse origins. Twelve compounds were highly active against all cell lines, 6 showed low activity, 12 no activity, and 13 exhibited a selective activity against a human small cell lung carcinoma cell line.

  DOI：

  10.1007/s00706-007-0838-4