(3S,4R,5S)-3-[tert-butyl(dimethyl)silyl]oxy-1-[(4-methoxyphenyl)methoxy]-4-methyl-10-trimethylsilyldec-9-yn-5-ol | 1008753-34-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3S,4R,5S)-3-[tert-butyl(dimethyl)silyl]oxy-1-[(4-methoxyphenyl)methoxy]-4-methyl-10-trimethylsilyldec-9-yn-5-ol
• CAS: 1008753-34-1
• 化学式: C₂₈H₅₀O₄Si₂
• 分子量: 506.874
• InChiKey: CTTLTKSNPGCLNI-NPAAKHOSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.04
• 重原子数：
  34
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (3S,4R,5S)-3-[tert-butyl(dimethyl)silyl]oxy-1-[(4-methoxyphenyl)methoxy]-4-methyl-10-trimethylsilyldec-9-yn-5-ol 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Stereoselective synthesis of the C33–C44 fragment of palau’amide

  摘要：

  An efficient stereoselective synthesis of the C33-C44 fragment of palau'amide is described using a Sharpless asymmetric epoxidation, a regioselective nucleophilic ring opening of the epoxide, a Grignard reaction and a Luche stereoselective reduction of a keto compound as the key steps. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.11.200
• 作为产物：
  描述：

  (2S,3S)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-2-methylpentanal 、 5-(trimethylsilyl)pent-4-yn-1-ylmagnesiumbromide 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 (3S,4R,5R)-3-[tert-butyl(dimethyl)silyl]oxy-1-[(4-methoxyphenyl)methoxy]-4-methyl-10-trimethylsilyldec-9-yn-5-ol 、 (3S,4R,5S)-3-[tert-butyl(dimethyl)silyl]oxy-1-[(4-methoxyphenyl)methoxy]-4-methyl-10-trimethylsilyldec-9-yn-5-ol
  参考文献：
  名称：

  Stereoselective synthesis of the C33–C44 fragment of palau’amide

  摘要：

  An efficient stereoselective synthesis of the C33-C44 fragment of palau'amide is described using a Sharpless asymmetric epoxidation, a regioselective nucleophilic ring opening of the epoxide, a Grignard reaction and a Luche stereoselective reduction of a keto compound as the key steps. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.11.200

文献信息

• Stereoselective synthesis of the C33–C44 fragment of palau’amide
  作者：Debendra K. Mohapatra、Sabita Nayak

  DOI：10.1016/j.tetlet.2007.11.200

  日期：2008.1

  An efficient stereoselective synthesis of the C33-C44 fragment of palau'amide is described using a Sharpless asymmetric epoxidation, a regioselective nucleophilic ring opening of the epoxide, a Grignard reaction and a Luche stereoselective reduction of a keto compound as the key steps. (C) 2007 Elsevier Ltd. All rights reserved.