4-amino-5-β-D-arabinofuranosyl-1(3)H-pyrimidin-2-one | 64891-50-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: 4-amino-5-β-D-arabinofuranosyl-1(3)H-pyrimidin-2-one
• 英文别名: 4-amino-1B-D-arabinofuranosyl-2-(1H)-pyrimidinone；6-amino-5-[(2S,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-pyrimidin-2-one
• CAS: 64891-50-5
• 化学式: C₉H₁₃N₃O₅
• 分子量: 243.219
• InChiKey: DZHQWVMWRUHHFF-JWXFUTCRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  137
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (4bS)-7c-hydroxy-6t-hydroxymethyl-(4br,7ac)-4b,6,7,7a-tetrahydro-1(3)H-furo[2',3':4,5]furo[2,3-d]pyrimidin-2-one 在 氨 作用下， 以 甲醇 为溶剂， 生成 4-amino-5-β-D-arabinofuranosyl-1(3)H-pyrimidin-2-one
  参考文献：
  名称：

  核苷。107. 5-（β-D-阿拉伯呋喃糖基）异胞嘧啶和相关的C-核苷的合成。

  摘要：

  DOI：

  10.1021/jm00199a017

文献信息

• Antiviral oligonucleotides having a conserved G4 core sequence
  申请人：Hanecak C. Ronnie

  公开号：US20070015723A1

  公开（公告）日：2007-01-18

  Modified oligonucleotides having a conserved G 4 sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus or phospholipase A 2 or to modulate the telomere length of a chromosome are provided. G 4 quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnostics and therapeutics for viral-associated diseases and diseases associated with elevated levels of phospholipase A 2 are also provided. Methods of modulating telomere length of a chromosome are also provided; modulation of telomere length is believed to play a role in the aging process of a cell and in control of malignant cell growth.

  提供具有保守的G4序列和足够数量的侧翼核苷酸的修饰寡核苷酸，可以显著抑制病毒或磷脂酶A2的活性或调节染色体端粒长度。还提供了G4四链体寡核苷酸结构。还提供了预防病毒相关疾病和与磷脂酶A2水平升高相关的疾病的诊断和治疗方法。还提供了调节染色体端粒长度的方法；调节染色体端粒长度被认为在细胞老化过程和恶性细胞生长的控制中起作用。
• Oligonucleotides having a conserved G4 core sequence
  申请人：ISIS PHARMACEUTICALS, INC.

  公开号：EP1016715A1

  公开（公告）日：2000-07-05

  Modified oligonucleotides having a conserved G4 sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus such as HSV-1 or phospholipase A2 or to modulate the telomere length of a chromosome are provided. G4 quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnostics and therapeutics for viral-associated diseases and diseases associated with elevated levels of phospholipase A2 are also provided. Methods of modulating telomere length of a chromosome are also provided; modulation of telomere length is believed to play a role in the aging process of a cell and in control of malignant cell growth.

  提供的修饰寡核苷酸具有保守的 G4 序列和足够数量的侧翼核苷酸，可显著抑制病毒（如 HSV-1 或磷脂酶 A2）的活性或调节染色体的端粒长度。还提供了 G4 四元组寡核苷酸结构。还提供了病毒相关疾病和磷脂酶 A2 水平升高相关疾病的预防、诊断和治疗方法。还提供了调节染色体端粒长度的方法；端粒长度的调节被认为在细胞衰老过程和控制恶性细胞生长中发挥作用。
• OLIGONUCLEOTIDE THERAPIES FOR MODULATING THE EFFECTS OF HERPESVIRUSES
  申请人：ISIS PHARMACEUTICALS, INC.

  公开号：EP0517859A1

  公开（公告）日：1992-12-16
• USE OF OLIGONUCLEOTIDES HAVING A CONSERVED G 4 CORE SEQUENCE FOR THE PREPARATION OF A MEDICAMENT
  申请人：ISIS PHARMACEUTICALS, INC.

  公开号：EP0672193B1

  公开（公告）日：2002-08-14
• OLIGONUCLEOTIDES HAVING A CONSERVED G 4? CORE SEQUENCE
  申请人：ISIS PHARMACEUTICALS, INC.

  公开号：EP0672193A1

  公开（公告）日：1995-09-20