[EN] ARYL-SULPHONAMIDIC DIMERS AS METALLOPROTEASES INHIBITORS<br/>[FR] DIMÈRES ARYL-SULFONAMIDIQUES EN TANT QU'INHIBITEURS DE MÉTALLOPROTÉASES
申请人:BRACCO IMAGING SPA
公开号:WO2010010080A1
公开(公告)日:2010-01-28
The invention relates to dimeric aryl-sulphonamido compounds endowed with inhibitory activity against metalloproteases MMP, having formula (I) below (M)-L-(M') (I), wherein M and M', the same or different from each other, represent the residues of the metalloproteases inhibitors of formula (II), wherein R, R1, R2, R3, G and n have the meanings reported in the specification; the invention also refers to the process for their preparation, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly in the treatment of degenerative disorders.