2-Dodecylhexadecanal | 922163-81-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Dodecylhexadecanal
• CAS: 922163-81-3
• 化学式: C₂₈H₅₆O
• 分子量: 408.7
• InChiKey: NDPQZBGPZJNEHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.4
• 重原子数：
  29
• 可旋转键数：
  25
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Lipid membrane structures
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP0348942A2

  公开（公告）日：1990-01-03

  Lipid membrane structures containing, in the lipid membrane thereof, a compound represented by formula (I): wherein R₁ represents a hydrogen atom or a fatty acid residue; R₂ represents a hydrogen atom or an acyclic hydrocarbon residue; R₃ represents an amino group, a guanidino group or an amidino group; and n represents an integer of from 1 to 6; provided that R₁ and R₂ do not represent hydrogen atoms at the same time, or a salt thereof. The lipid membrane structures exhibit excellent specific affinity for tumor cells and can be delivered preferentially to tumor cells.

  在其脂膜中含有式(I)代表的化合物的脂膜结构： 其中 R₁ 代表氢原子或脂肪酸残基；R₂ 代表氢原子或无环烃残基；R₃ 代表氨基、胍基或脒基；n 代表 1 至 6 的整数；但 R₁ 和 R₂ 不能同时代表氢原子，或其盐。 脂膜结构对肿瘤细胞具有极佳的特异性亲和力，可优先输送到肿瘤细胞。
• Muramyl peptide derivatives and immunoregulating compositions containing them
  申请人：Hasegawa, Akira

  公开号：EP0385467A1

  公开（公告）日：1990-09-05

  Muramyl peptide derivatives of the formula : wherein "Ala" is "isoGln" is R¹ is R₃O- or R₃S-[R₃ is (k is an integer from 8 to 12; q is an integer from 10 to 22) or R₃ is (m is an integer from 11 to 17; n is an integer from 11 to 17)]; and R₂ is hydrogen atom or -CO-(CH₂)p-CH₃ (p is an integer from 8 to 22); which act on in vivo immunomechanism of human beings and livestock (in particular cells relevant immue responses) and are useful as immunoregulating agents.

  式中的 Muramyl 肽衍生物： 其中 "Ala "是 "异谷氨酸 "是 R¹ 是 R₃O- 或 R₃S-[R₃ 是 (k 是 8 至 12 的整数；q 是 10 至 22 的整数）或 R₃ 是 (m 是 11 至 17 的整数；n 是 11 至 17 的整数)]；且 R₂ 是氢原子或 -CO-(CH₂)p-CH₃ (p 是 8 至 22 的整数)； 它们对人和牲畜的体内免疫机制（特别是与免疫反应相关的细胞）起作用，可用作免疫调节剂。
• Novel muramyldipeptide derivatives and influenza vaccine comprising the derivatives
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP0487909A2

  公开（公告）日：1992-06-03

  Novel muramyldipeptide derivatives such as [6-0-(2-tetradecylhexadecanoyl)-N-acetylmuramoyl]-L-alanyl-D-glutamide and [6-0-(2-tetradecylhexadecanoyl)-N-acetylmuramoyl]-L-alanyl-N -methyl-D-glutamamide are provided. The muramyldipeptide derivatives are excellent compound as an adjuvant or a constituting component of virosome vaccine. An influenza vaccine comprises a complex of the muramyldipeptide derivative and an influenza virus antigen. The influenza vaccine has excellent antibody-producing capacity and safety.

  本研究提供了新型的喃二肽衍生物，如[6-0-(2-十四烷基十六酰基)-N-乙酰基戊酰基]-L-丙氨酰-D-谷酰胺和[6-0-(2-十四烷基十六酰基)-N-乙酰基戊酰基]-L-丙氨酰-N-甲基-D-谷酰胺。这些呋喃二肽衍生物是用作佐剂或病毒体疫苗构成成分的极佳化合物。一种流感疫苗由喃喃二肽衍生物和流感病毒抗原复合物组成。该流感疫苗具有极佳的抗体产生能力和安全性。
• Novel muramyldipeptide derivatives
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP0680974A1

  公开（公告）日：1995-11-08

  Novel muramyldipeptide derivatives such as [6-0-(2-tetradecylhexadecanoyl)-N-acetylmuramoyl]-L-alanyl-D-glutamide and [6-0-(2-tetradecylhexadecanoyl)-N-acetylmuramoyl]-L-alanyl-N -methyl-D-glutamamide are provided. The muramyldipeptide derivatives are excellent compound as an adjuvant or a constituting component of virosome vaccine.

  本研究提供了新型的喃二肽衍生物，如[6-0-(2-十四烷基十六酰基)-N-乙酰基戊酰基]-L-丙氨酰-D-谷酰胺和[6-0-(2-十四烷基十六酰基)-N-乙酰基戊酰基]-L-丙氨酰-N-甲基-D-谷酰胺。这些呋喃二肽衍生物是用作佐剂或病毒体疫苗构成成分的极佳化合物。
• US5075287A
  申请人：——

  公开号：US5075287A

  公开（公告）日：1991-12-24