3-(3-Methoxyphenoxy)azetidine | 954220-79-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(3-Methoxyphenoxy)azetidine
• CAS: 954220-79-2
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.219
• InChiKey: QRHBRUDGTZWRJB-UHFFFAOYSA-N

物化性质

• 沸点：
  290.1±30.0 °C(Predicted)
• 密度：
  1.116±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  3-(3-Methoxyphenoxy)azetidine 、 10-chloro-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl ester 在 N,N-二异丙基乙胺 作用下， 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Novel 6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]indene analogues as potent and selective 5-HT2C agonists for the treatment of metabolic disorders

  摘要：

  The discovery of a novel series of 5-HT2C agonists based on a tricyclic pyrazolopyrimidine scaffold is described. Compounds with good levels of in vitro potency and moderate to good levels of selectivity with respect to the 5-HT2A and 5-HT2B receptors were identified. One of the analogues (7g) was found to be efficacious in a sub-chronic weight loss model. A key limitation of the series of compounds was that they were found to be potent inhibitors of the hERG ion channel. Some compounds, bearing polar side chains were identified which showed a much reduced hERG liability however these compounds were sub-optimal in terms of their in vitro potency or selectivity. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.11.089

文献信息

• Metal-free Synthesis of Aryl Amines: Beyond Nucleophilic Aromatic Substitution
  作者：Alexander H. Sandtorv、David R. Stuart

  DOI：10.1002/anie.201610086

  日期：2016.12.19

  salt electrophiles and secondary aliphatic amine nucleophiles. This reaction results in direct ipso‐substitution of the iodonium moiety and unsymmetrical aryl(TMP)iodonium salts are primarily employed. Moreover, arene substituents and substitution patterns that currently pose a challenge to classical metal‐free methods are accommodated and the alicyclic amine nucleophiles used here are unprecedented

  描述了一种温和且无金属的C-N偶联方法，该方法使用二芳基碘鎓盐亲电试剂和脂肪族仲胺亲核试剂。该反应导致碘鎓部分直接ipso取代，主要使用不对称的芳基（TMP）碘鎓盐。此外，可以容纳目前对经典的无金属方法构成挑战的芳烃取代基和取代形式，并且此处使用的脂环族胺亲核试剂在其他当代的无金属CN偶联反应中是前所未有的。
• Hydrochloride salt of 5-[3-(3-hydroxyphenoxy) azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide
  申请人：Glossop Paul Alan

  公开号：US20100113409A1

  公开（公告）日：2010-05-06

  This invention relates to the hydrochloride salt of 5-[3-3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenyl-hexanamide or derived form thereof and its use as a medicament.

  本发明涉及5-[3-3-羟基苯氧基)氮杂环己酰胺-5-甲基-2,2-二苯基-或其衍生物的盐，并作为药物使用。
• HYDROCHLORIDE SALT OF 5-[3-(3-HYDROXYPHENOXY)AZETIDIN-1-YL]-5-METHYL-2,2- DIPHENYLHEXANAMIDE
  申请人：Pfizer Limited

  公开号：EP2125714A1

  公开（公告）日：2009-12-02
• US8263583B2
  申请人：——

  公开号：US8263583B2

  公开（公告）日：2012-09-11
• [EN] HYDROCHLORIDE SALT OF 5-R3-F3-TIVDROXYPHENOXY)AZETIDIp-1-Vp-5-METHYL-2.2- DIPHENYLHEXANAMIDE<br/>[FR] SEL HYDROCHLORURE DE 5-R3-F3-TIVDROXYPHÉNOXY)AZÉTIDIN-1-YL]-5-MÉTHYL-2,2- DIPHÉNYLHEXANAMIDE
  申请人：PFIZER LTD

  公开号：WO2008135819A1

  公开（公告）日：2008-11-13

  [EN] This invention relates to the hydrochloride salt of 5-[3-3-hydroxyphenoxy)azetidin-1-yl]-5- methyl-2,2-diphenylhexanamide or derived form thereof and its use as a medicament.
  [FR] L'invention concerne le sel hydrochlorure de 5-[3-3-hydroxyphénoxy)azétidin-1-yl]-5- méthyl-2,2-diphénylhexanamide ainsi qu'une forme dérivée de ce dernier et son utilisation en tant que médicament.