5-chloro-3-(2,4-dimethoxyphenyl)-3-hydroxy-1,3-dihydroindol-2-one | 352278-18-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-chloro-3-(2,4-dimethoxyphenyl)-3-hydroxy-1,3-dihydroindol-2-one
• 英文别名: 5-chloro-3-(2,4-dimethoxyphenyl)-3-hydroxy-1H-indol-2-one
• CAS: 352278-18-3
• 化学式: C₁₆H₁₄ClNO₄
• 分子量: 319.744
• InChiKey: ZOMWVTYXEODTLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-chloro-3-(2,4-dimethoxyphenyl)-3-hydroxy-1,3-dihydroindol-2-one 在 吡啶 、 氯化亚砜 、 potassium tert-butylate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 26.0h， 生成 (+/-)-5-chloro-3-(2,4-dimethoxyphenyl)-3-(4-pyridin-4-ylpiperazin-1-yl)-1-(quinoline-8-sulfonyl)-1,3-dihydroindol-2-one
  参考文献：
  名称：

  WO2008/107399

  摘要：

  公开号：

文献信息

• Novel 1,3-dihydro-2H-indol-2one derivatives, process for preparing them and pharmaceutical compositions containing them
  申请人：——

  公开号：US20040209938A1

  公开（公告）日：2004-10-21

  The invention relates to compounds of formula: 1 as well as the possible salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, which have affinity for and selectivity towards the V 1b receptors or towards both the V 1b and V 1a receptors of arginine-vasopressin. The invention also relates to the process for preparing them, to the intermediate compounds of formula (II) that are useful for preparing them, to pharmaceutical compositions containing them and to their use for the preparation of medicinal products.

  本发明涉及以下式子的化合物1，以及可能的与矿物质或有机酸形成的盐，以及溶剂化合物和/或水合物，这些化合物对精氨酸加压素的V1b受体或V1b和V1a受体都具有亲和力和选择性。本发明还涉及制备它们的方法，有用于制备它们的式子(II)的中间体化合物，含有它们的制药组合物以及它们用于制备药物的用途。
• Novel 1,3-dihydro-2H-indol-2-one derivatives, process for preparing them and pharmaceutical compositions containing them
  申请人：Roux Richard

  公开号：US20050176770A1

  公开（公告）日：2005-08-11

  The invention relates to compounds of formula: and to solvates and/or hydrates thereof, with affinity for and selectivity towards the V 1b receptors or both the V 1b and V 1a receptors of arginine-vasopressin. The invention also relates to a process for preparing them, to the intermediate compounds of formula (II) which are useful for preparing them, to pharmaceutical compositions containing them and to their use for preparing medicinal products.

  本发明涉及式的化合物：以及其溶剂化物和/或水合物，具有亲和力和选择性，对精氨酸加压素的V1b受体或V1a和V1b受体均有亲和力。本发明还涉及制备它们的方法，用于制备它们的有用的式（II）的中间化合物，含有它们的制药组合物以及它们用于制备药物的用途。
• Novel 1,3-dihydro-2h-indol-2-one, preparation method and pharmaceutical compositions containing same
  申请人：——

  公开号：US20030109545A1

  公开（公告）日：2003-06-12

  The invention relates to compounds of formula: 1 and their solvates and/or hydrates exhibiting an affinity and a selectivity for arginine-vasopressin V 1b receptors or for both V 1b and V 1a receptors.

  本发明涉及公式1的化合物及其溶剂化物和/或水合物，具有对精氨酸加压素V1b受体或V1b和V1a受体的亲和力和选择性。
• Novel 1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for v1b and v1a arginine-vasopressin receptors
  申请人：——

  公开号：US20030114683A1

  公开（公告）日：2003-06-19

  The invention relates to compounds of formula: 1 as well as the possible salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, which have affinity for and selectivity towards the V 1b receptors or towards both the V 1b and V 1a receptors of arginine-vasopressin. The invention also relates to the process for preparing them, to the intermediate compounds of formula (II) that are useful for preparing them, to pharmaceutical compositions containing them and to their use for the preparation of medicinal products.

  本发明涉及以下化合物的公式：1，以及可能的与矿物质或有机酸盐和其溶剂和/或水合物，这些化合物具有亲和力和选择性，可以作用于精氨酸加压素的V1b受体或V1b和V1a受体。本发明还涉及制备它们的过程，有用于制备它们的公式（II）的中间化合物，包含它们的制药组合物以及它们用于制备药物的用途。
• Novel 1,3-dihydro-2h-indol-2-one derivatives, method for preparing same and pharmaceutical compositions containing them
  申请人：——

  公开号：US20030162767A1

  公开（公告）日：2003-08-28

  The invention relates to compounds of formula: 1 and to solvates and/or hydrates thereof, with affinity for and selectivity towards the V 1b receptors or both the V 1b and V 1a receptors of arginine-vasopressin. The invention also relates to a process for preparing them, to the intermediate compounds of formula (II) which are useful for preparing them, to pharmaceutical compositions containing them and to their use for preparing medicinal products.

  本发明涉及式子1的化合物及其溶剂化物和/或水合物，它们具有亲和力和选择性，可作用于精氨酸加压素的V1b受体或V1a和V1b受体。本发明还涉及制备它们的方法，用于制备它们的有用中间体化合物（II），含有它们的制药组合物以及它们用于制备药物的用途。