N-Tetradecanoylglycylglycine | 94105-67-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Tetradecanoylglycylglycine
• 英文别名: 2-[[2-(tetradecanoylamino)acetyl]amino]acetic acid
• CAS: 94105-67-6
• 化学式: C₁₈H₃₄N₂O₄
• 分子量: 342.5
• InChiKey: XLYVYEJHGMXZAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-Tetradecanoylglycylglycine 以 甲醇 为溶剂， 反应 24.0h， 以N-tetradecanoyl-glycyl-glycine water-free organic nanotubes (yielding: 0.48 g)的产率得到N-tetradecanoyl-glycyl-glycine water
  参考文献：
  名称：

  HOLLOW FIBROUS ORGANIC NANOTUBE AND PRODUCTION METHOD THEREOF

  摘要：

  本发明公开了一种合成无水纳米管的方法，该方法能够大量高效地封装功能物质。该方法包括：将下列通式（1）所表示的N-糖苷型糖脂或下列通式（2）和（3）所表示的肽-脂共轭物溶解于加热至沸点以下温度的有机溶剂中，其中，通式（1）中，G代表糖的缩合物，缩合物的半乙醇羟基与糖的缩合物的一个非环氧碳原子上的氢原子形成的羟基不包括在内；R1代表具有10至39个碳原子的不饱和烃基；通式（2）和（3）中，R2代表具有6至24个碳原子的碳氢基；R3代表氨基酸侧链；m代表1至10的整数。然后，（i）缓慢冷却所得溶液，并在室温下保持冷却的溶液不受干扰，或（ii）浓缩所得溶液，并在室温下保持浓缩的溶液受干扰，或（iii）向所得溶液中加入N-糖苷型糖脂或肽-脂共轭物的劣溶剂，并在室温下保持混合溶液不受干扰；从得到的溶液中收集在静止溶液中自组装形成的空心纤维有机纳米管，并通过在室温下空气干燥或在减压下加热干燥来获得空心纤维有机纳米管。

  公开号：

  US20090202641A1

文献信息

• HOLLOW-FIBER-LIKE ORGANIC NANOTUBE AND PROCESS FOR PRODUCTION THEREOF
  申请人：National Institute of Advanced Industrial Science and Technology

  公开号：EP2033934A1

  公开（公告）日：2009-03-11

  Disclosed is a method of synthesizing a water-free nanotube capable of efficiently encapsulating a functional substance therein, in large quantities. The method comprises: dissolving, in an organic solvent heated up to a temperature equal to or less than a boiling point thereof, an N-glycoside type glycolipid represented by the following general formula (1): G-NHCO-R1 (wherein G represents a sugar residue from which a hemiacetal hydroxyl group bonded to an anomeric carbon atom of the sugar is excluded; and R1 represents an unsaturated hydrocarbon group having 10 to 39 carbon atoms), or a peptide-lipid conjugate represented by one of the following general formulas (2) and (3): R2CO (NH-CHR3-CO)m OH and H (NH-CHR3-CO)m NHR2 (wherein: R2 represents a hydrocarbon group having 6 to 24 carbon atoms; R3 represents an amino-acid side chain; and m represents an integer of 1 to 10); (i) slowly cooling the obtained solution, and maintaining the cooled solution undisturbed at room temperature, or (ii) concentrating the obtained solution, and maintaining the concentrated solution disturbed at room temperature, or (iii) adding to the obtained solution a poor solvent for the N-glycoside type glycolipid or the peptide-lipid conjugate, and maintaining the mixed solution undisturbed at room temperature; collecting from the resulting solution a hollow fibrous organic nanotube formed through self-assembling in the stationary solution, and drying the collected hollow fibrous organic nanotube, in air at room temperature or by heating under reduced-pressure, to obtain a hollow fibrous organic nanotube.

  本发明公开了一种合成无水纳米管的方法，该纳米管能够大量有效地封装功能物质。该方法包括：在加热至等于或低于其沸点温度的有机溶剂中溶解由以下通式（1）表示的 N-糖苷型糖脂：G-NHCO-R1（其中 G 代表糖残基，其中与糖的异构碳原子结合的半缩醛羟基被排除；R1 代表具有 10 至 39 个碳原子的不饱和烃基），或由下列通式（2）和（3）之一代表的肽脂共轭物：R2CO（NH-CHR3-CO）m OH 和 H（NH-CHR3-CO）m NHR2（其中：R2 代表具有 6 至 24 个碳原子的烃基；R3 代表氨基酸侧链；m 代表 1 至 10 的整数）；(i) 缓慢冷却所得溶液，并将冷却后的溶液保持在室温下不受干扰，或 (ii) 浓缩所得溶液，并将浓缩后的溶液保持在室温下不受干扰，或 (iii) 向所得溶液中加入 N-糖苷型糖脂或肽脂共轭物的劣溶剂，并将混合溶液保持在室温下不受干扰；从所得溶液中收集在固定溶液中自组装形成的中空纤维状有机纳米管，并在室温空气中或通过减压加热干燥所收集的中空纤维状有机纳米管，以获得中空纤维状有机纳米管。
• Composition
  申请人：AJINOMOTO CO., INC.

  公开号：US11331255B2

  公开（公告）日：2022-05-17

  Provided is a composition containing the following components (A), (B) and (C) and suppressing formation of scum during cleansing, wherein a weight ratio of (A)/(B) is 0.2-5 and a weight ratio of ((A)+(B))/(C) is 0.01-10: (A) N-lauroyl glycine or a salt thereof (B) N-myristoyl glycine or a salt thereof (C) N-acyl acidic amino acid having an acyl group having 8 to 24 carbon atoms, or a salt thereof.

  本发明提供了一种含有以下成分（A）、（B）和（C）的组合物，可在清洁过程中抑制浮渣的形成，其中（A）/（B）的重量比为 0.2-5，（（A）+（B））/（C）的重量比为 0.01-10： (A) N-月桂酰甘氨酸或其盐 (B) N-肉豆蔻酰甘氨酸或其盐 (C) 具有 8 至 24 个碳原子的酰基的 N-酰基酸性氨基酸或其盐。
• COMPOSITION
  申请人：AJINOMOTO CO., INC.

  公开号：US20200085712A1

  公开（公告）日：2020-03-19

  Provided is a composition containing the following components (A), (B) and (C) and suppressing formation of scum during cleansing, wherein a weight ratio of (A)/(B) is 0.2-5 and a weight ratio of ((A)+(B))/(C) is 0.01-10: (A) N-lauroyl glycine or a salt thereof (B) N-myristoyl glycine or a salt thereof (C) N-acyl acidic amino acid having an acyl group having 8 to 24 carbon atoms, or a salt thereof.
• HOLLOW FIBROUS ORGANIC NANOTUBE AND PRODUCTION METHOD THEREOF
  申请人：Asakawa Masumi

  公开号：US20090202641A1

  公开（公告）日：2009-08-13

  Disclosed is a method of synthesizing a water-free nanotube capable of efficiently encapsulating a functional substance therein, in large quantities. The method comprises: dissolving, in an organic solvent heated up to a temperature equal to or less than a boiling point thereof, an N-glycoside type glycolipid represented by the following general formula (1): G-NHCO—R 1 (wherein G represents a sugar residue from which a hemiacetal hydroxyl group bonded to an anomeric carbon atom of the sugar is excluded; and R 1 represents an unsaturated hydrocarbon group having 10 to 39 carbon atoms), or a peptide-lipid conjugate represented by one of the following general formulas (2) and (3): R 2 CO(NH—CHR 3 —CO) m OH and H(NH—CHR 3 —CO) m NHR 2 (wherein: R 2 represents a hydrocarbon group having 6 to 24 carbon atoms; R 3 represents an amino-acid side chain; and m represents an integer of 1 to 10); (i) slowly cooling the obtained solution, and maintaining the cooled solution undisturbed at room temperature, or (ii) concentrating the obtained solution, and maintaining the concentrated solution disturbed at room temperature, or (iii) adding to the obtained solution a poor solvent for the N-glycoside type glycolipid or the peptide-lipid conjugate, and maintaining the mixed solution undisturbed at room temperature; collecting from the resulting solution a hollow fibrous organic nanotube formed through self-assembling in the stationary solution, and drying the collected hollow fibrous organic nanotube, in air at room temperature or by heating under reduced-pressure, to obtain a hollow fibrous organic nanotube.

  本发明公开了一种合成无水纳米管的方法，该方法能够大量高效地封装功能物质。该方法包括：将下列通式（1）所表示的N-糖苷型糖脂或下列通式（2）和（3）所表示的肽-脂共轭物溶解于加热至沸点以下温度的有机溶剂中，其中，通式（1）中，G代表糖的缩合物，缩合物的半乙醇羟基与糖的缩合物的一个非环氧碳原子上的氢原子形成的羟基不包括在内；R1代表具有10至39个碳原子的不饱和烃基；通式（2）和（3）中，R2代表具有6至24个碳原子的碳氢基；R3代表氨基酸侧链；m代表1至10的整数。然后，（i）缓慢冷却所得溶液，并在室温下保持冷却的溶液不受干扰，或（ii）浓缩所得溶液，并在室温下保持浓缩的溶液受干扰，或（iii）向所得溶液中加入N-糖苷型糖脂或肽-脂共轭物的劣溶剂，并在室温下保持混合溶液不受干扰；从得到的溶液中收集在静止溶液中自组装形成的空心纤维有机纳米管，并通过在室温下空气干燥或在减压下加热干燥来获得空心纤维有机纳米管。