4-allyl isophthalic acid | 1264220-10-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-allyl isophthalic acid
• 英文别名: 4-prop-2-enylbenzene-1,3-dicarboxylic acid
• CAS: 1264220-10-1
• 化学式: C₁₁H₁₀O₄
• 分子量: 206.198
• InChiKey: XUPSKGIEOCEMLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-allyl isophthalic acid 在 双(乙腈)氯化钯(II) 氧气 、 sodium carbonate 、 盐酸 作用下， 以 四氢呋喃 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 3-methyl-1-oxo-1H-isochromene-7-carboxylic acid
  参考文献：
  名称：

  NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE

  摘要：

  提供一个基于调节5-HT5A受体的作用，用于预防或治疗痴呆、精神分裂症等的优秀药剂。[解决方案]确认了酰脒衍生物（以下公式I；Z1、Z2、Z3、Z4和Z5中的任何一个为氮原子，其余为碳原子）具有特征性结构，其中脒基通过羰基与喹啉或异喹啉的一个环连接，并且另一个环连接有环状基团，展现出强大的5-HT5A受体调节作用和基于5-HT5A受体调节作用的优秀药理作用，因此可作为预防或治疗痴呆、精神分裂症、双相情感障碍或注意力缺陷多动障碍的优秀药剂。因此，完成了本发明。

  公开号：

  US20120142727A1

文献信息

• Nitrogenous-ring acylguanidine derivative
  申请人：Kinoyama Isao

  公开号：US08853242B2

  公开（公告）日：2014-10-07

  [Object] An excellent agent for preventing or treating dementia, schizophrenia, and the like, based on serotonin 5-HT5A receptor modulating action, is provided. [Means for Solution] It was confirmed that acylguanidine derivatives (the following formula I; any one of Z1, Z2, Z3, Z4 and Z5 is nitrogen atom, and the others are carbon atoms) which have the characteristic structure in which the guanidine is bonded to one ring of the quinoline or isoquinoline via a carbonyl group, and a cyclic group is bonded to the other ring, exhibit potent 5-HT5A receptor modulating actions and excellent pharmacological actions based on the 5-HT5A receptor modulating action, and thus can be excellent agents for preventing or treating dementia, schizophrenia, bipolar disorder, or attention deficit hyperactivity disorder. Thus, the present invention has been completed.

  [目的] 提供一种基于血清素5-HT5A受体调节作用的出色的防治痴呆症、精神分裂症等的制剂。 [解决方案] 确认了酰基胍衍生物（以下式I；其中Z1、Z2、Z3、Z4和Z5中的任意一个是氮原子，其余为碳原子），其具有胍基通过羰基与喹啉或异喹啉的一个环结合，另一个环结合有环状基团的特征结构，表现出强效的5-HT5A受体调节作用和基于5-HT5A受体调节作用的出色的药理作用，因此可以成为防治痴呆症、精神分裂症、躁郁症或注意力缺陷多动障碍的出色制剂。因此，本发明已经完成。
• Unsaturated group-containing multi-branched compounds, curable compositions containing the same, and cured products thereof
  申请人：Miyabe Hidekazu

  公开号：US20050064336A1

  公开（公告）日：2005-03-24

  A curable composition is obtained by mixing a polymerization initiator (B) or further a thermosetting component with an unsaturated group-containing multi-branched compound (A-1)-(A-4) obtained by the reaction of (a) a compound containing at least two epoxy groups in its molecule with (b) a compound containing at least two (but at least three when the component (a) mentioned above is a polyfunctional epoxy compound containing two epoxy groups) carboxyl groups and/or phenolic hydroxyl groups in its molecule and (c) an unsaturated monocarboxylic acid or a compound containing at least one unsaturated double bond-containing group, or an unsaturated group-containing multi-branched compound (A-5)-(A-8) having a carboxyl group and obtained by further causing (d) a polybasic acid anhydride to react with a hydroxyl group of the unsaturated group-containing multi-branched compound mentioned above.

  将聚合引发剂（B）或热固性成分与含不饱和基团的多支链化合物（A-1）-（A- 4）混合，可得到固化组合物。4）与(b)分子中含有至少两个（但当上述成分(a)为含有两个环氧基团的多官能团环氧化合物时，至少三个）羧基和/或酚羟基的化合物和(c)不饱和单羧酸或含有至少一个不饱和双键基团的化合物反应而得、或通过进一步使(d)聚碱性酸酐与上述含不饱和基团的多支链化合物的羟基反应而得到的具有羧基的含不饱和基团的多支链化合物(A-5)-(A-8)。
• Unsaturated polyester compounds, resins curable with actinic energy ray, processes for the production thereof, and curable compositions
  申请人：——

  公开号：US20040039087A1

  公开（公告）日：2004-02-26

  An unsaturated polyester compound having an ethylenically unsatureated group in its terminal and hydroxymethyl group in its side chain is obtained by the reaction of (a) a compound containing at least two oxetane rings in its molecule with (b) a compound containing at least two carboxyl groups in its molecule and (c) an unsaturated monocarboxylic acid in the presence of a reaction promotor in such a proportion that the ratio of said compound (b) to said compound (a) falls in the range of 0.1<(b)/(a)<1. BY further reacting (d) a polybasic acid anhydride with the resultant unsaturated polyester compound (A′), there is obtained an actinic energy ray-curable resin which is soluble in an aqueous alkaline solution. A photocurable and/or thermosetting composition is obtained by mixing the unsaturated polyester compound (A′) and/or the actinic energy ray-curable resin with a polymerization initiator (B).
• US6906116B2
  申请人：——

  公开号：US6906116B2

  公开（公告）日：2005-06-14
• US8853242B2
  申请人：——

  公开号：US8853242B2

  公开（公告）日：2014-10-07