2-(2-benzimidazolylthio)valeric acid | 21547-72-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(2-benzimidazolylthio)valeric acid
• 英文别名: 2--valeriansaeure；2-(1H-benzoimidazol-2-ylsulfanyl)-pentanoic acid；2-(1H-benzimidazol-2-ylsulfanyl)pentanoic acid
• CAS: 21547-72-8
• 化学式: C₁₂H₁₄N₂O₂S
• 分子量: 250.321
• InChiKey: FJCOCZRHPDNXQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  91.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2-benzimidazolylthio)valeric acid 在 吡啶 、 乙酸酐 作用下， 反应 1.0h， 以50%的产率得到2-propylbenzoimidazolo<2,1-b>thiazolidin-3-one
  参考文献：
  名称：

  Synthesis and antimicrobial activity of some 2-alkyl-2H-1,4-benzothiazin-3(4H)-ones and 2-alkylbenzo[d]imidazolo[2,1-b]-thiazolidin-3-ones

  摘要：

  Sodium 2-aminothiophenoxide (1) reacts with ethyl 2-bromoalkanoates (2) under direct cyclization to form 2-alkyl-2H-1,4-benzothiazin-3(4H)-ones (3). Reaction of the sodium salt of 2-mercaptobenzimidazole (4) with 2 or 2-bromoalkanoic acids (5) affords only S-alkylated products (6 or 7, respectively). The cyclization products - 2-alkylbenzo[d] imidazolo[2,1-b]thiazolidin-3-ones (8)- can be obtained only from the corresponding 2-(2-benzimidazolylthio)alkanoic acids (7) by the action of acetic anhydride. Both compounds 3 and 8 exhibit only moderate antimicrobial activity against some gram-positive bacteria.

  DOI：

  10.1007/bf00812716
• 作为产物：
  描述：

  2-溴戊酸乙酯 在 sodium hydroxide 、 sodium ethanolate 作用下， 以 水 为溶剂， 反应 8.5h， 生成 2-(2-benzimidazolylthio)valeric acid
  参考文献：
  名称：

  Synthesis and antimicrobial activity of some 2-alkyl-2H-1,4-benzothiazin-3(4H)-ones and 2-alkylbenzo[d]imidazolo[2,1-b]-thiazolidin-3-ones

  摘要：

  Sodium 2-aminothiophenoxide (1) reacts with ethyl 2-bromoalkanoates (2) under direct cyclization to form 2-alkyl-2H-1,4-benzothiazin-3(4H)-ones (3). Reaction of the sodium salt of 2-mercaptobenzimidazole (4) with 2 or 2-bromoalkanoic acids (5) affords only S-alkylated products (6 or 7, respectively). The cyclization products - 2-alkylbenzo[d] imidazolo[2,1-b]thiazolidin-3-ones (8)- can be obtained only from the corresponding 2-(2-benzimidazolylthio)alkanoic acids (7) by the action of acetic anhydride. Both compounds 3 and 8 exhibit only moderate antimicrobial activity against some gram-positive bacteria.

  DOI：

  10.1007/bf00812716

文献信息

• Light stabilising polymer dispersants in pigment dispersions
  申请人：Vogel Thomas

  公开号：US20060229407A1

  公开（公告）日：2006-10-12

  The present invention relates to a novel polymerisate, which is prepared by applying the method of atom transfer radical polymerisation. The novel polymerisate is useful for stabilising a composition of matter susceptible to degradation induced by light, heat or oxidation. The novel polymerisate is also useful as a dispersant in a pigment dispersion containing dispersible inorganic or organic pigment particles. Further embodiments of the invention relate to the process for preparing the novel polymerisate by applying the method of controlled or “living” polymerisation and to the use of the pigment dispersion for preparing inks, colour filters, coatings, images, lacquers and others.

  本发明涉及一种新型聚合酸盐，它是通过原子转移自由基聚合方法制备的。这种新型聚合异酸酯可用于稳定易受光、热或氧化作用影响而降解的物质成分。这种新型聚合异构体还可用作颜料分散体中的分散剂，该颜料分散体中含有可分散的无机或有机颜料颗粒。本发明的其他实施方案涉及通过应用受控聚合或 "活 "聚合方法制备新型聚合酸盐的工艺，以及颜料分散体在制备油墨、滤色片、涂料、图像、油漆等方面的用途。
• Ogura,H. et al., Chemical and pharmaceutical bulletin, 1968, vol. 16, # 11, p. 2167 - 2171
  作者：Ogura,H. et al.

  DOI：——

  日期：——
• PIGMENT COMPOSITIONS WITH MODIFIED ATRP COPOLYMER DISPERSANTS
  申请人：BASF SE

  公开号：EP1465935B1

  公开（公告）日：2016-09-07
• LIGHT STABILISING POLYMER DISPERSANTS IN PIGMENT DISPERSIONS
  申请人：BASF SE

  公开号：EP1611197B1

  公开（公告）日：2012-03-21
• US7723425B2
  申请人：——

  公开号：US7723425B2

  公开（公告）日：2010-05-25