二酯与三酯等 | 37318-31-3

• 物质功能分类: 表面活性剂 - 非离子表面活性剂 - 多元醇酯型
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 二酯与三酯等
• 中文别名: Β-D-呋喃果糖基-Α-D-吡喃葡糖苷十八酸酯；蔗糖脂肪酸酯；蔗糖硬脂酸酯；脂肪酸蔗糖酯；蔗糖酯
• 英文名称: Sucrose Stearate
• 英文别名: (2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;octadecanoic acid
• CAS: 37318-31-3；25168-73-4
• 化学式: C30H58O13
• 分子量: 626.8
• InChiKey: ONAIRGOTKJCYEY-XXDXYRHBSA-N

物化性质

• 熔点：
  67-71 °C
• 溶解度：
  极微溶于水，微溶于乙醇（96%）。
• LogP：
  5.749 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  0.94
• 重原子数：
  43
• 可旋转键数：
  21
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  227
• 氢给体数：
  9
• 氢受体数：
  13

安全信息

• 海关编码：
  2940000000
• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

制备方法与用途

简介

蔗糖硬脂酸酯是一种蔗糖酯。它是由蔗糖和脂肪酸或其衍生物通过酯化或酯交换反应合成的产物。作为一种来源于可再生资源的产品，蔗糖酯具有卓越的应用性能、良好的生物降解性和毒理学安全性，并对环境友好。作为重要的天然表面活性剂，它被广泛应用于食品、医药、化妆品及洗涤剂中。

制备

1. 硬脂酸乙酯的制备

   将42.65g硬脂酸加入三口烧瓶中并升温至熔化状态。在搅拌下加入0.5mL浓硫酸和55mL无水乙醇，于80℃左右反应约8小时后结束反应。减压蒸馏去除乙醇，并用KOH调节pH值为6～7，随后进行热水洗涤以分离出粗酯。对粗酯进行精制，最终得到产品。

2. 蔗糖酯的制备

   将一定量的硬脂酸乙酯、丙二醇、蔗糖和K₂CO₃加入到250mL三口烧瓶中，并加热至90℃反应。在完成反应后加入酒石酸并减压蒸馏大部分溶剂，将残渣加入8%氯化钠溶液中直至形成明显的分层界面。去除水层得到蔗糖酯粗品，再使用乙酸乙酯进一步纯化粗品，真空干燥至恒重以获得白色蜡状固体。

用途

蔗糖硬脂酸酯能够提高药物的加工性能、崩解性能及溶出度，从而提升产品质量。特别适用于口服头孢菌素类、大环内酯类抗生素以及青霉素类抗生素、弹性蛋白酶、干扰素和N4-酰基阿糖胞苷等。

生产方法

将3摩尔蔗糖与1摩尔脂肪酸甲酯溶解于二甲基甲酰胺(DMF)溶剂中，使用K₂CO₃作催化剂，在90～95℃、10～13kPa的压力条件下进行反应。然后去除多余的甲醇及蔗糖，即可获得产品。

文献信息

• Process for production of high-monoester sucrose higher fatty acid esters
  申请人：DAI-ICHI KOGYO SEIYAKU CO., LTD.

  公开号：EP0560081A1

  公开（公告）日：1993-09-15

  The invention relates to a method of producing a high-monoester sucrose higher fatty acid ester with a monoester content of at least 90%. In accordance with this invention, a sucrose higher fatty acid ester which is actually a mixture of the corresponding monoester, diester, triester, etc. is dissolved in 1 to 12 parts by weight of a solvent having a specific inductive capacity, at 25°C, of 30 to 50 at an elevated temperature, the precipitate formed on subsequent cooling is removed to recover a supernatant and the solvent is removed from the supernatant. In accordance with the invention, a high-monoester sucrose higher fatty acid ester can be produced easily and with good reproducibility.

  本发明涉及一种生产单酯含量至少为 90%的高单酯蔗糖高级脂肪酸酯的方法。根据本发明，将蔗糖高级脂肪酸酯（实际上是相应的单酯、二酯、三酯等的混合物）溶解在 1 至 12 重量份的溶剂中，该溶剂在 25°C 时的比感量为 30 至 50，然后在高温下冷却，除去冷却时形成的沉淀，回收上清液，并从上清液中除去溶剂。根据本发明，可以轻松生产出高单酯蔗糖高级脂肪酸酯，且重现性良好。
• Thermal transfer recording material and thermal transfer recording method
  申请人：KONICA CORPORATION

  公开号：EP1231072A2

  公开（公告）日：2002-08-14

  A thermal transfer recording material comprising a support having thereon an image transferring layer containing a coloring material represented by Formula (I), wherein each R11 and R12 is independently a substituted or unsubstituted aliphatic group; R13 is a substituent and n is an integer of 0 to 4, provided that when n is 2 or more, a plurality of R13s are the same or different; R14 is an alkyl group; and each R15 and R16 is independently an alkyl group having 3 to 8 carbon atoms.

  一种热转印记录材料，包括一个支撑体，支撑体上有一个含有由式（I）表示的着色材料的图像转移层、 其中每个 R11 和 R12 独立地为取代或未取代的脂肪族基团；R13 为取代基，n 为 0 至 4 的整数，但当 n 为 2 或更多时，多个 R13 相同或不同；R14 为烷基；每个 R15 和 R16 独立地为具有 3 至 8 个碳原子的烷基。
• PROCESS FOR PRODUCING CONCENTRATED/PURIFIED PROTEIN USING CLAY MINERAL COMPOSITION
  申请人：THE NISSHIN OIL MILLS, LTD.

  公开号：EP1445261A1

  公开（公告）日：2004-08-11

  A method of separating a protein characterized in that the protein absorbed by a clay mineral composition is separated by using one or more members selected from a group consisting of fatty acid esters having 30 or less carbon atoms in the fatty acid residue. According to this method, a target protein can be conveniently and economically obtained in a large amount on an industrial scale at a high efficiency without deteriorating its functions (for example, lowering the enzymatic activity). Thus, the protein can be concentrated and purified.

  一种分离蛋白质的方法，其特征在于被粘土矿物组合物吸收的蛋白质是通过使用一种或多种选自脂肪酸酯组的成员来分离的，这些脂肪酸酯组的脂肪酸残基中具有 30 个或更少的碳原子。根据这种方法，可以方便、经济、高效地在工业规模上大量获得目标蛋白质，而不会降低其功能（例如降低酶活性）。因此，蛋白质可以浓缩和纯化。
• PROCESS FOR PRODUCING DRUG ULTRAMICROPARTICLE AND APPARATUS THEREFOR
  申请人：Eisai Co., Ltd.

  公开号：EP1652515A1

  公开（公告）日：2006-05-03

  The present invention provides fine drug particles with submicron sizes excellent in long-term dispersibility. Specifically, it provides a method for producing ultrafine drug particles having an average particle size of 10 nm to 1000 nm, by 1) dissolving a drug in a good solvent or a mixture of good solvents to prepare a drug-containing solution; 2) mixing the drug-containing solution with a solvent being a poor solvent or a mixture of poor solvents for the drug and being miscible with the drug-containing solution in the good solvent or a mixture of good solvents; and 3) subjecting the prepared mixture directly to emulsification under a set processing pressure using a high-pressure homogenizer without carrying out a pretreatment step for adjusting the drug to have an average particle size of 100 µm or less, and an apparatus for producing the particles.

  本发明提供长期分散性极佳的亚微米级精细药物颗粒。具体地说，本发明提供了一种生产平均粒径为 10 纳米至 1000 纳米的超细药物颗粒的方法，具体方法是：1）将药物溶解在良好溶剂或良好溶剂的混合物中，制备含药溶液；2）将含药溶液与药物的劣溶剂或劣溶剂的混合物混合，并在良好溶剂或良好溶剂的混合物中与含药溶液混溶；3) 使用高压匀浆器在设定的加工压力下直接对制备好的混合物进行乳化，而不进行预处理步骤，以调整药物的平均粒径为 100 微米或更小，以及生产颗粒的设备。
• SITOSTEROL COMPOUND-CONTAINING COMPOSITION AND PROCESS FOR PRODUCING THE SAME
  申请人：SAN-EI GEN F.F.I., INC.

  公开号：EP1839501A1

  公开（公告）日：2007-10-03

  A method for producing a phytosterol/phytostanol-containing composition is provided that facilitates dispersion in water of a phytosterol and/or phytostanol (phytosterol/phytostanol), which are difficult to dissolve in water, inhibits the occurrence of precipitation and coagulation (ring formation) for a long period of time even when incorporated in water, and can maintain a stable dispersed state. The method of the present invention has at least one of the following steps (1) to (3): (1) mixing at least one type selected from a pulverized phytosterol and phytostanol with an aqueous raw material containing an emulsifier having an HLB value of 6 to 16; (2) pulverizing at least one type selected from a phytosterol and a phytostanol followed by mixing with an aqueous raw material containing an emulsifier having an HLB value of 6 to 16; and (3) mixing at least one type selected from a phytosterol and a phytostanol with an aqueous raw material containing an emulsifier having an HLB value of 6 to 16, and pulverizing the phytosterol and/or phytostanol in the mixture.

  本发明提供了一种生产含植物甾醇/植物甾醇组合物的方法，该方法可促进难溶于水的植物甾醇和/或植物甾醇（植物甾醇/植物甾醇）在水中的分散，即使加入水中也能长时间抑制沉淀和凝结（成环）的发生，并能保持稳定的分散状态。本发明的方法具有以下步骤（1）至（3）中的至少一个步骤：(1) 将至少一种选自粉碎植物甾醇和植物甾醇的物质与含有 HLB 值为 6 至 16 的乳化剂的水性原料混合；(2) 将至少一种选自植物甾醇和植物甾醇的物质粉碎，然后与含有 HLB 值为 6 至 16 的乳化剂的水性原料混合；和 (3) 将至少一种选自植物甾醇和植物甾醇的物质与含有 HLB 值为 6 至 16 的乳化剂的水性原料混合，并粉碎混合物中的植物甾醇和/或植物甾醇。