3,4-Dichlor-6-methyl-pyridazin | 22390-45-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3,4-Dichlor-6-methyl-pyridazin
• 英文别名: 3,4-dichloro-6-methyl-pyridazine；3,4-Dichloro-6-methylpyridazine
• CAS: 22390-45-0
• 化学式: C₅H₄Cl₂N₂
• 分子量: 163.006
• InChiKey: YOUPASAGLWSIJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,4-Dichlor-6-methyl-pyridazin 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 、 异丙醇 为溶剂， 反应 30.0h， 生成 N-(6-methyl-4-methylsulfonylpyridazin-3-yl)-1H-benzimidazol-5-amine
  参考文献：
  名称：

  [EN] NEW BENZIMIDAZOLE PYRIDINE DERIVATIVES
  [FR] NOUVEAUX DÉRIVES DE BENZIMIDAZOLE PYRIDINE

  摘要：

  The invention relates to a compound of formula (I) wherein A1, A2, A3, R1, R2, R2', R3, R4and R5are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

  公开号：

  WO2023139085A1

文献信息

• Substituted Pyridazinyl- and Pyrimidinyl-Quinolin-4-Ylamine Analogues
  申请人：Caldwell Timothy M.

  公开号：US20080175794A1

  公开（公告）日：2008-07-24

  Substituted pyridazinyl- and pyrimidinyl-quinolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  本发明提供了替代吡啶并嘧啶基喹啉-4-胺类似物。此类化合物是配体，可以用于调节体内或体外特定受体的活性，并在治疗与人类、家畜伴侣动物和家畜动物中的病理性受体激活相关的疾病方面特别有用。本发明还提供了制备这些药物组合物和使用它们治疗这些疾病的方法，以及使用此类配体进行受体定位研究的方法。
• Synthesis and pharmacological study of 5h-pyridazino[3,4-b]1,4-benzoxazines (3,4-diazaphenoxazines)
  作者：N. V. Savitskaya、T. V. Gortinskaya、V. G. Nyrkova、I. N. Fedorova、A. I. Polezhaeva、M. D. Mashkovskii、M. N. Shchukina、T. V. Vlasova

  DOI：10.1007/bf00779120

  日期：1977.1
• NEW CHEMICAL COMPOUNDS (DERIVATIVES) AND THEIR APPLICATION FOR THE TREATMENT OF ONCOLOGICAL DISEASES
  申请人：LIMITED LIABILITY COMPANY "NATIONAL PHARMACEUTICAL TECHNOLOGIES"

  公开号：US20160200729A1

  公开（公告）日：2016-07-14

  The invention relates to novel chemical compounds of general formula I, in which L A , L B , L C , ring A, ring B, R A , R B , R C , R D , R E and R F have are defined in the description, and which are protein kinases inhibitors. The invention also relates to pharmaceutical compositions containing said compounds and also to the use of said compounds for treatment and/or prevention of diseases related with aberrant protein kinase activity.
• US9695182B2
  申请人：——

  公开号：US9695182B2

  公开（公告）日：2017-07-04
• [EN] NEW BENZIMIDAZOLE PYRIDINE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVES DE BENZIMIDAZOLE PYRIDINE
  申请人：[en]F. HOFFMANN-LA ROCHE AG

  公开号：WO2023139085A1

  公开（公告）日：2023-07-27

  The invention relates to a compound of formula (I) wherein A1, A2, A3, R1, R2, R2', R3, R4and R5are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.