1-(2-Methoxy-phenyl)-3-methyl-but-2-en-1-ol | 141992-08-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(2-Methoxy-phenyl)-3-methyl-but-2-en-1-ol
• 英文别名: 1-(2-Methoxyphenyl)-3-methylbut-2-en-1-ol
• CAS: 141992-08-7
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.258
• InChiKey: KNRMCYIURKOCDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2-Methoxy-phenyl)-3-methyl-but-2-en-1-ol 在 吡啶 、 三氯氧磷 作用下， 以 二氯甲烷 为溶剂， 以75%的产率得到(E)-1-methoxy-2-(3-methylbuta-1,3-dien-1-yl)benzene
  参考文献：
  名称：

  烯丙醇转化为共轭二烯

  摘要：

  氯氧化磷和吡啶将烯丙基醇以良好或优异的产率转化为共轭二烯。

  DOI：

  10.1016/s0040-4039(00)79052-6

文献信息

• Use Of 3-Substituted-2-(Diphenylmethy)-1-Azabicyclo[2.2.2]Octanes For Treating Mrg-X1 Receptor Mediated Diseases
  申请人：Kunapuli Priya

  公开号：US20080027095A1

  公开（公告）日：2008-01-31

  The invention encompasses a method for treating a disease or condition mediated by the human MRG-X1 receptor, such as nociception, hyperalgesia, allodynia, pain related to central hypersensitivity conditions, somatic pain, visceral pain, acute pain, chronic pain, post-operative pain, headache, inflammatory pain, neurological pain, musculoskeletal pain, cancer related pain or vascular pain, in a human patient in need thereof comprising administering to the patient a therapeutically effective amount of a 3-substituted-2-(diphenylmethy)-1-azabicyclo[2.2.2]octane or a pharmaceutically acceptable salt thereof. The invention is also directed to the use of these compounds as molecular tools to directly explore the role of the MRG-X1 receptor in pain perception.
• METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING PRURITIS
  申请人：Dong Xinzhong

  公开号：US20120073001A1

  公开（公告）日：2012-03-22

  The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.
• US9771592B2
  申请人：——

  公开号：US9771592B2

  公开（公告）日：2017-09-26
• [EN] METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING PRURITIS<br/>[FR] PROCÉDÉ ET COMPOSITION POUR LE TRAITEMENT OU LA PRÉVENTION DU PRURIT
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2010065085A2

  公开（公告）日：2010-06-10

  The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.
• Conversion of allylic alcohols into conjugated dienes
  作者：Craig S. Runk、Sara M. Haverty、Daniel A. Klein、William R. McCrea、Eric D. Strobel、Harold W. Pinnick

  DOI：10.1016/s0040-4039(00)79052-6

  日期：1992.5

  Phosphorus oxychloride and pyridine convert allylic alcohols into conjugated dienes in good to excellent yields.

  氯氧化磷和吡啶将烯丙基醇以良好或优异的产率转化为共轭二烯。