methanesulfonic acid 2-{1-[7-(4-bromo-2,6-dimethyl-phenyl)-2,5,6-trimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-piperidin-4-yl}-ethyl ester | 872866-02-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: methanesulfonic acid 2-{1-[7-(4-bromo-2,6-dimethyl-phenyl)-2,5,6-trimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-piperidin-4-yl}-ethyl ester
• 英文别名: 2-[1-[7-(4-bromo-2,6-dimethylphenyl)-2,5,6-trimethylpyrrolo[2,3-d]pyrimidin-4-yl]piperidin-4-yl]ethyl methanesulfonate
• CAS: 872866-02-9
• 化学式: C₂₅H₃₃BrN₄O₃S
• 分子量: 549.532
• InChiKey: TZDSNVFHLBWOGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  85.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  methanesulfonic acid 2-{1-[7-(4-bromo-2,6-dimethyl-phenyl)-2,5,6-trimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-piperidin-4-yl}-ethyl ester 、 氰乙酸乙酯 在 sodium hydride 、 sodium iodide 作用下， 以 四氢呋喃 为溶剂， 反应 3.5h， 生成 4-{1-[7-(4-bromo-2,6-dimethyl-phenyl)-2,5,6-trimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-piperidin-4-yl}-2-cyano-butyric acid ethyl ester
  参考文献：
  名称：

  [EN] PYRROLOPYRIMIDINE AND PYRROLOPYRIDINE DERIVATIVES SUBSTITUTED WITH A CYCLIC AMINO GROUP AS CRF ANTAGONISTS
  [FR] DÉRIVÉS DE PYRROLOPYRIMIDINE ET DE PYRROLOPYRIDINE SUBSTITUÉS PAR UN GROUPE AMINO CYCLIQUE SERVANT D'ANTAGONISTES DU CRF

  摘要：

  本发明的目的是提供一种针对CRF受体的拮抗剂和/或对受体的激动剂，作为治疗或预防与CRF有关的疾病的有效药物，如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、胃肠疾病、药物依赖、脑梗死、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、脱发、肠易激综合征、睡眠障碍、癫痫、皮肤炎、精神分裂症、疼痛等疾病。具有以下式[I]所示的带有环状氨基团的吡咯吡嘧啶或吡咯吡啶衍生物对CRF受体和/或δ受体具有高亲和力，并对与CRF有关的疾病有效。

  公开号：

  WO2006001511A1

文献信息

• Novel tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCRs)
  申请人：Paulini Klaus

  公开号：US20060014818A1

  公开（公告）日：2006-01-19

  The present invention provides novel tetrahydrocarbazole derivatives which have improved properties and which can be employed as inhibitors of GPCRs. This results in the possibility of using the novel compounds to treat pathological conditions whose severity depends on the pathobiochemical effect of GPCRs. The compounds of the invention act in particular via an antagonistic inhibition of the LHRH receptor. The invention further provides medicaments which comprise one or more of the novel compounds as active ingredient. The medicaments are suitable in particular to be employed in an oral dosage form for a mammal, in particular a human.

  本发明提供了新颖的四氢咔唑衍生物，具有改进的性能，并可用作GPCR的抑制剂。这导致可以利用这些新型化合物来治疗病理条件，其严重程度取决于GPCR的病理生物化学效应。本发明的化合物特别通过对LHRH受体的拮抗性抑制发挥作用。本发明还提供了包含一种或多种新型化合物作为活性成分的药物。这些药物特别适合用于口服剂型，用于哺乳动物，特别是人类。
• Pyrrolopyrimidine and Pyrrolopyridine Derivatives Substituted with a Cyclic Amino Group As Crf Antagonists
  申请人：Nakazato Atsuro

  公开号：US20080280928A1

  公开（公告）日：2008-11-13

  [PROBLEM TO BE SOLVED] An object of the present invention is to provide an antagonist against CRF receptors and/or an agonist for δ receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal diseases, drug dependence, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, pain, etc. [SOLUTION] A pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by the following a [I] has a high affinity for CRF receptors and/or δ receptors, and is effective against diseases in which CRF is considered to be involved.

  【问题需解决】本发明的目的是提供一种针对CRF受体的拮抗剂和/或δ受体的激动剂，其作为治疗或预防CRF参与的疾病，如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、胃肠疾病、药物依赖、脑梗塞、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、脱发、肠易激综合征、睡眠障碍、癫痫、皮炎、精神分裂症、疼痛等方面的治疗或预防药物。 【解决方案】一种通过以下a[I]所代表的环状氨基基团取代的吡咯吡嘧啶或吡咯吡啶衍生物具有高亲和力，可用于CRF受体和/或δ受体，并对CRF参与的疾病具有治疗作用。
• Pyrrolo[2,3-D]pyrimidine derivatives substituted with a cyclic amino group
  申请人：Taisho Pharmaceutical Co., Ltd.

  公开号：US07951811B2

  公开（公告）日：2011-05-31

  [PROBLEM TO BE SOLVED] An object of the present invention is to provide an antagonist against CRF receptors and/or an agonist for δ receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal diseases, drug dependence, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, pain, etc. [SOLUTION] A pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by the following a [I] has a high affinity for CRF receptors and/or δ receptors, and is effective against diseases in which CRF is considered to be involved.

  【需要解决的问题】本发明的目的是提供一种针对CRF受体的拮抗剂和/或δ受体的激动剂，该药物对于CRF可能涉及的疾病如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、胃肠疾病、药物依赖、脑梗死、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、脱发、肠易激综合症、睡眠障碍、癫痫、皮炎、精神分裂症、疼痛等具有治疗或预防作用。 【解决方案】下列式a [I]所表示的带有环状氨基基团的吡咯吡嘧啶或吡咯吡啶衍生物具有高亲和力，可针对CRF受体和/或δ受体，对于CRF可能涉及的疾病具有治疗作用。
• PYRROLOPYRIMIDINE AND PYRROLOPYRIDINE DERIVATIVES SUBSTITUTED WITH A CYCLIC AMINO GROUP AS CRF ANTAGONISTS
  申请人：NAKAZATO Atsuro

  公开号：US20110124862A1

  公开（公告）日：2011-05-26

  [Problem to be Solved] An object of the present invention is to provide an antagonist against CRF receptors and/or an agonist for δ receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal diseases, drug dependence, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, pain, etc. [Solution] A pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by the following formula [I] has a high affinity for CRF receptors and/or δ receptors, and is effective against diseases in which CRF is considered to be involved.

  【待解决的问题】本发明的目的是提供一种CRF受体的拮抗剂和/或δ受体的激动剂，作为治疗或预防CRF参与的疾病（如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈病、进食障碍、高血压、胃肠疾病、药物依赖、脑梗塞、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、脱发、肠易激综合征、睡眠障碍、癫痫、皮炎、精神分裂症、疼痛等）的有效药物。 【解决方案】以下式[I]所表示的带有环状氨基基团的吡咯吡嘧啶或吡咯吡啶衍生物具有高亲和力，可作为CRF受体和/或δ受体的拮抗剂，对于CRF参与的疾病具有治疗效果。
• Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with a cyclic amino group as CRF antagonists
  申请人：TAISHO PHARMACEUTICAL CO., LTD

  公开号：EP1953160A1

  公开（公告）日：2008-08-06

  [PROBLEM TO BE SOLVED] An object of the present invention is to provide an antagonist against CRF receptors and/or an agonist for receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal diseases, drug dependence, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, pain, etc. [SOLUTION] A pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by formula [I] has a high affinity for CRF receptors and/or δ receptors, and is effective against diseases in which CRF is considered to be involved.

  [有待解决的问题］ 本发明的目的是提供一种针对CRF受体的拮抗剂和/或受体激动剂，其作为治疗或预防CRF被认为参与的疾病（如抑郁症、焦虑症、阿尔茨海默氏病、帕金森氏病）的有效药物、亨廷顿舞蹈症、饮食失调、高血压、胃肠道疾病、药物依赖、脑梗塞、脑缺血、脑水肿、头外伤、炎症、免疫相关疾病、脱发、肠易激综合征、睡眠障碍、癫痫、皮肤病、精神分裂症、疼痛等。 [解决方案］ 一种由式[I]代表的环状氨基取代的吡咯并嘧啶或吡咯并嘧啶衍生物对CRF受体和/或δ受体具有高亲和力，对CRF被认为参与的疾病有效。