5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin | 958881-90-8

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 喜树碱
• 英文名称: 5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin
• 英文别名: (12S,19S)-19-ethyl-19-hydroxy-12-(2-hydroxyethoxy)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
• CAS: 958881-90-8
• 化学式: C₂₂H₂₀N₂O₆
• 分子量: 408.411
• InChiKey: XAKLYHGHEFMDAP-UNMCSNQZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (4S)-4-乙基-4-羟基-12-(2-羟基乙氧基)-1H-吡喃并[3',4':6,7]吲哚嗪并[1,2-b]喹啉-3,14(4H,12H)-二酮 以 正丁醇 为溶剂， 反应 7.0h， 生成 5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin
  参考文献：
  名称：

  WO2007/140239

  摘要：

  公开号：

文献信息

• CRYSTALLINE FORM OF 5(S)-(2-HYDROXYETHOXY)-20(S)-CAMPTOTHECIN
  申请人：Akella Venkateswarlu

  公开号：US20080076790A1

  公开（公告）日：2008-03-27

  A crystalline form of 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin diastereoisomer of 5(RS)-(2′-hydroxyethoxy)-20(S)-camptothecin is described that is characterized by having an X-ray powder diffraction pattern comprising one or more peak intensities expressed in degrees 2θ that are selected from the group consisting of 7.2±0.1, 9.4±0.1, 11.02±0.1, 12.00±0.1, 14.54±0.1, 15.2±0.1, 18.92±0.1, 21.86±0.1, 22.74±0.1 and 26.42±0.1. Methods of making and using the compound are also described.
• 5(S)-(2'-HYDROXYETHOXY)-20(S)-CAMPTOTHECIN AND ITS PREPARATION AND USE FOR THE TREATMENT OF CANCER
  申请人：Akella Venkateswarlu

  公开号：US20080076791A1

  公开（公告）日：2008-03-27

  A 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin diasterisomer is described which is a better inhibitor of topoisomerase I than either the diastereoisomeric mixture 5(RS)-(2′-hydroxyethoxy)-20(S)-camptothecin, or the 5(R)-(2′-hydroxyethoxy)-20(S)-camptothecin diastereoisomer. Pharmaceutical compositions of the 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin diastereoisomer are also described as are methods of using the compound for the inhibition of topoisomerase I and for the treatment of cancer.
• PHARMACEUTICAL COMPOSITIONS OF [5(S)-(2'-HYDROXYETHOXY)-20(S)-CAMPTOTHECIN
  申请人：Nekkanti Vijay Kumar

  公开号：US20110177161A1

  公开（公告）日：2011-07-21

  There is provided a powder composition for use in a pharmaceutical product, the composition including a) 5(S)-(2′-hydroxyethoxy)-20(S)-CPT; at least one cyclodextrin; wherein 5(S)-(2′-hydroxyethoxy)-20(S)-CPT includes less than 5% of 5(R)-(2′-hydroxyethoxy)-20(S)-CPT. Preferably, in the powder composition, 5(S)-(2′-hydroxyethoxy)-20(S)-CPT is substantially free from said 5(R)-(2′-hydroxyethoxy)-20(S)-CPT.
• US7601732B2
  申请人：——

  公开号：US7601732B2

  公开（公告）日：2009-10-13
• US7601733B2
  申请人：——

  公开号：US7601733B2

  公开（公告）日：2009-10-13