(4-chloro-2-methoxybenzylidene)malononitrile | 901771-44-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (4-chloro-2-methoxybenzylidene)malononitrile
• 英文别名: 2-[(4-chloro-2-methoxyphenyl)methylidene]propanedinitrile
• CAS: 901771-44-6
• 化学式: C₁₁H₇ClN₂O
• 分子量: 218.642
• InChiKey: YRSJUTNBUNOKEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  56.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氯-2-甲氧基苯甲醛 、 丙二腈 生成 (4-chloro-2-methoxybenzylidene)malononitrile
  参考文献：
  名称：

  Bicyclic Pyrimidines as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes

  摘要：

  本发明涉及一种新型的取代双环嘧啶，它们是二肽基肽酶-IV酶（“DPP-IV抑制剂”）的抑制剂，可用于治疗或预防二肽基肽酶-IV酶参与的疾病，如糖尿病，特别是2型糖尿病。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗二肽基肽酶-IV酶参与的这些疾病中使用这些化合物和组合物。

  公开号：

  US20090105210A1

文献信息

• Bicyclic pyrimidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
  申请人：Merck Sharp & Dohme Corp.

  公开号：US07956061B2

  公开（公告）日：2011-06-07

  The present invention is directed to novel substituted bicyclic pyrimidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及一种新型取代双环嘧啶，其为二肽基肽酶IV酶（“DPP-IV抑制剂”）的抑制剂，可用于治疗或预防涉及二肽基肽酶IV酶的疾病，如糖尿病，特别是2型糖尿病。本发明还涉及包含这些化合物的制药组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶IV酶的疾病中的使用。
• BICYCLIC PYRIMIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
  申请人：Merck & Co., Inc.

  公开号：EP1841770A2

  公开（公告）日：2007-10-10
• EP1841770A4
  申请人：——

  公开号：EP1841770A4

  公开（公告）日：2009-03-04
• US7956061B2
  申请人：——

  公开号：US7956061B2

  公开（公告）日：2011-06-07
• [EN] BICYCLIC PYRIMIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES<br/>[FR] PYRIMIDINES BICYCLIQUES EN TANT QU'INHIBITEURS DE LA DIPEPTIDYL-PEPTIDASE-IV DANS LE TRAITEMENT OU LA PREVENTION DE DIABETES
  申请人：MERCK & CO INC

  公开号：WO2006078676A2

  公开（公告）日：2006-07-27

  [EN] The present invention is directed to novel substituted bicyclic pyrimidines which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DPP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
  [FR] La présente invention concerne des nouvelles pyrimidines bicycliques substituées qui constituent des inhibiteurs de l'enzyme de la dipeptidyl-peptidase-IV ("inhibiteurs DPP-IV") et qui sont utilisées dans le traitement ou la prévention de maladies, dans lesquelles est impliquée ladite enzyme, telles que des diabètes et, notamment, des diabète de type 2. Cette invention a aussi pour objet des compositions pharmaceutiques renfermant ces composés et l'utilisation desdits composés et compositions dans la prévention ou le traitement de ces maladies, dans lesquelles est impliquée l'enzyme de la dipeptidyl-peptidase-IV.