2-(8-hydroxy-7-oxo-octyl)cyclopent-2-en-1-one,7-ethylene ketal | 72079-09-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-(8-hydroxy-7-oxo-octyl)cyclopent-2-en-1-one,7-ethylene ketal
• 英文别名: 2-[6-[2-(Hydroxymethyl)-1,3-dioxolan-2-yl]hexyl]cyclopent-2-en-1-one
• CAS: 72079-09-5
• 化学式: C₁₅H₂₄O₄
• 分子量: 268.353
• InChiKey: XTRCOTPKUCRDAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(8-hydroxy-7-oxo-octyl)cyclopent-2-en-1-one 在 对甲苯磺酸 作用下， 以 乙二醇 、 甲苯 为溶剂， 生成 2-(8-hydroxy-7-oxo-octyl)cyclopent-2-en-1-one,7-ethylene ketal
  参考文献：
  名称：

  1-Hydroxymethyl-1-oxo-prostane derivatives of the E.sub.2 series

  摘要：

  拥有E.sub.2系列中1-(羟甲基)-1-氧代-前列酮结构的前列酮的衍生物、类似物和同系物。

  公开号：

  US04170597A1

文献信息

• 1-Hydroxymethyl-1-oxo-prostane-derivatives of the E, A and F-series
  申请人：American Cyanamid Company

  公开号：US04254036A1

  公开（公告）日：1981-03-03

  The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain a substituent selected from the group consisting of: ##STR1## wherein R is an alkyl group and R.sub.15 is C.sub.1 -C.sub.4 alkyl, di-C.sub.1 -C.sub.4 -alkylamino, C.sub.1 -C.sub.4 alkoxy, and phenyl or phenyl substituted with one or more substituents from the group consisting of C.sub.1 -C.sub.4, OR, SR, F, or Cl wherein R is as previously defined.

  本发明涉及具有在α链的末端亚甲基碳上选择自以下组成的取代基的E、F或A系列药理活性前列腺素衍生物：##STR1##其中R是烷基基团，R.sub.15是C.sub.1 -C.sub.4烷基，二C.sub.1 -C.sub.4-烷基氨基，C.sub.1 -C.sub.4烷氧基，苯基或苯基，其上取代基来自C.sub.1 -C.sub.4，OR，SR，F或Cl的组成，其中R如前所定义。
• 1-Hydroxymethyl-1-oxo-prostane derivatives of the E.sub.2 series
  申请人：American Cyanamid Company

  公开号：US04170597A1

  公开（公告）日：1979-10-09

  Derivatives, analogs, and congeners of prostane having a 1-(hydroxymethyl)-1-oxo-prostane structure in the E.sub.2 series.

  拥有E.sub.2系列中1-(羟甲基)-1-氧代-前列酮结构的前列酮的衍生物、类似物和同系物。
• 1-Hydroxymethyl-1-1-oxo prostane derivatives of the E and F series
  申请人：American Cyanamid Company

  公开号：US04254285A1

  公开（公告）日：1981-03-03

  The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain a substituent selected from the group consisting of: ##STR1## wherein R is an alkyl group and R.sub.15 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, di-C.sub.1 -C.sub.4 -alkylamino, and phenyl orphenyl substituted with one or more substituents selected from the group consisting of C.sub.1 -C.sub.4 alkyl, OR, SR, F, or Cl wherein R is as previously defined.

  本发明涉及具有在α链的末端亚甲基碳上选择自以下组成的取代基的E、F或A系列药理活性前列腺素衍生物：##STR1## 其中R是烷基基团，R.sub.15是C.sub.1 -C.sub.4烷基，C.sub.1 -C.sub.4烷氧基，二C.sub.1 -C.sub.4-烷基氨基，以及苯基或苯基取代物，所述苯基或苯基取代物中取代基选择自C.sub.1 -C.sub.4烷基，OR，SR，F或Cl的组成，其中R如前所定义。