Methyl 4-amino-4-(4-chlorophenyl)butanoate | 1184634-07-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 4-amino-4-(4-chlorophenyl)butanoate
• CAS: 1184634-07-8
• 化学式: C₁₁H₁₄ClNO₂
• 分子量: 227.691
• InChiKey: ICBJENRFGZSHBK-UHFFFAOYSA-N

物化性质

• 沸点：
  331.5±37.0 °C(Predicted)
• 密度：
  1.188±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  methyl 4-azido-4-(4-chlorophenyl)butanoate 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 Methyl 4-amino-4-(4-chlorophenyl)butanoate
  参考文献：
  名称：

  Tandem Ring-Opening Decarboxylation of Cyclopropane Hemimalonates with Sodium Azide: A Short Route to γ-Aminobutyric Acid Esters

  摘要：

  Cyclopropane hemimalonates, when treated with sodium azide, undergo a tandem ring-opening decarboxylation to produce gamma-azidobutyric acids in good yields. These adducts were hydrogenated to form gamma-aminobutyric acid (GABA) methyl esters.

  DOI：

  10.1021/jo3010606

文献信息

• METHOD OF PRODUCING POLYARYLENE SULFIDE AND POLYARYLENE SULFIDE
  申请人：Kureha Corporation

  公开号：US20160068636A1

  公开（公告）日：2016-03-10

  PROBLEM: To provide a method of producing a polyarylene sulfide (PAS) such as polyphenylene sulfide (PPS) in which a dihalo aromatic compound and a sulfur source containing an alkali metal are polymerized in an organic amide solvent, whereby a PAS is produced at higher yield and the amount of NaCl produced as a by-product is reduced to not greater than half that of conventional methods, and, due to a dehydration step being omissible, PAS with excellent practical utility is produced with high productivity in a short time. SOLUTION: A method of producing a PAS in which a dihalo aromatic sulfide compound represented by the formula: X—(—Ar—S—) n —Ar—X (in the formula, Ar represents an optionally substituted aromatic group, X represents a halogen atom, and n is from 1 to 10) and a sulfur source containing an alkali metal are polymerized in an organic amide solvent; and a PAS of which an average particle size is from 10 to 5000 μm, a melt viscosity measured at a temperature of 310° C. and a shear rate of 1216 sec −1 is from 0.1 to 3000 Pa·s, and a nitrogen content is not greater than 500 ppm.
• US9422402B2
  申请人：——

  公开号：US9422402B2

  公开（公告）日：2016-08-23