5-(chloromethyl)furo[3,2-b]pyridine | 1025421-42-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃吡啶类
• 英文名称: 5-(chloromethyl)furo[3,2-b]pyridine
• CAS: 1025421-42-4
• 化学式: C₈H₆ClNO
• mdl: MFCD18803184
• 分子量: 167.595
• InChiKey: SPDWIZXYWNXCTN-UHFFFAOYSA-N

物化性质

• 沸点：
  240.7±25.0 °C(Predicted)
• 密度：
  1.316±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  26
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-(chloromethyl)furo[3,2-b]pyridine 、 6-((1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)thio)phthalazin-1(2H)-one 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-(furo[3,2-b]pyridin-5-ylmethyl)-6-((1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)thio)phthalazin-1(2H)-one
  参考文献：
  名称：

  [EN] PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS
  [FR] DÉRIVÉS DE PHTALAZINE UTILISÉS COMME MODULATEURS DE LA PYRUVATE KINASE

  摘要：

  The invention relates to compounds of formula (Ia) and to their use in treating or preventing an inflammatory disease, a disease associated with an undesirable immune response, cancer, obesity, a diabetic disease or a blood disorder: wherein RA, RB, RCand RD, X, Y1, Y2, Y3, Z1, Z2and m are as defined herein.

  公开号：

  WO2023079294A1
• 作为产物：
  描述：

  methyl 2,3-dihydrofuro[3,2-b]pyridine-5-carboxylate 在 氯化亚砜 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 5-(chloromethyl)furo[3,2-b]pyridine
  参考文献：
  名称：

  [EN] PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS
  [FR] DÉRIVÉS DE PHTALAZINE UTILISÉS COMME MODULATEURS DE LA PYRUVATE KINASE

  摘要：

  The invention relates to compounds of formula (Ia) and to their use in treating or preventing an inflammatory disease, a disease associated with an undesirable immune response, cancer, obesity, a diabetic disease or a blood disorder: wherein RA, RB, RCand RD, X, Y1, Y2, Y3, Z1, Z2and m are as defined herein.

  公开号：

  WO2023079294A1

文献信息

• Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein
  作者：Dwight Macdonald、Christine Brideau、Chi Chung Chan、Jean-Pierre Falgueyret、Richard Frenette、Jocelyne Guay、John H. Hutchinson、Hélène Perrier、Peptiboon Prasit、Denis Riendeau、Philip Tagari、Michel Thérien、Robert N. Young、Yves Girard

  DOI：10.1016/j.bmcl.2008.01.105

  日期：2008.3

  The discovery and SAR of a novel series of substituted 2,2-bisaryl-bicycloheptane inhibitors of 5-lipoxygenase activating protein ( FLAP) are herein described. SAR studies have shown that 2,5-substitution on the exo-aryl group is optimal for potency. The most potent compounds in this series have an ortho-nitrogen aryl linked with a methyleneoxy as the 5-substituent and a polar group such as a urethane as the 2-substituent. One of the most potent compounds identified is the 5- benzothiazolymethoxy-2-pyridinylcarbamate derivative 2 ( FLAP IC50 = 2.8 nM) which blocks 89% of ragweed induced urinary LTE4 production in dogs ( at an I. V. dose of 2.5 mu g/kg/min). This compound inhibits calcium ionophore stimulated LTB4 production in both human polymorphonuclear ( PMN) leukocytes and human whole blood ( IC50 = 2.0 and 33 nM, respectively). (c) 2008 Elsevier Ltd. All rights reserved.