meso-2,3-Dimethyl-monosuccinamid | 89639-48-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: meso-2,3-Dimethyl-monosuccinamid
• 英文别名: 4-Amino-2,3-dimethyl-4-oxobutanoic acid
• CAS: 89639-48-5
• 化学式: C₆H₁₁NO₃
• 分子量: 145.158
• InChiKey: IIXKFEKAYWUBLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  80.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  、 meso-2,3-Dimethyl-monosuccinamid 在 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 生成
  参考文献：
  名称：

  Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors

  摘要：

  丁酰氨基羟基乙氨基磺酰脲衍生物的公式如下： 其中，取代基的定义如说明书所述，这些衍生物作为逆转录病毒蛋白酶抑制剂是有效的，尤其是作为HIV蛋白酶的抑制剂。

  公开号：

  US06337398B1

文献信息

• DERIVATIVE OF STYRENE-MALEIC ACID COPOLYMER
  申请人：Maeda Hiroshi

  公开号：US20160317672A1

  公开（公告）日：2016-11-03

  The present invention provides a group of novel SMA derivatives and a covalent conjugate of the derivatives and an active substance. More specifically, the present invention provides: an SMA derivative which contains (i) a styrene-maleic acid copolymer (SMA) and (ii) a side chain (b) that contains a functional group (a) selected from among —NH2, —SH, —OH, —COOH, —NH—(C═NH)—NH 2 and —C(CH 2 —OH) 3 and introduced into a carboxyl group of a maleic acid residue of the SMA via an amide bond or an ester bond, and wherein when a plurality of side chain (b) is introduced into the SMA, the side chains (b) may be identical or different from each other; and a conjugate of this SMA derivative and an active substance.

  本发明提供了一组新型SMA衍生物以及这些衍生物和活性物质的共价结合物。具体来说，本发明提供了：一种包含（i）苯乙烯-马来酸共聚物（SMA）和（ii）含有从—NH2、—SH、—OH、—COOH、—NH—(C═NH)—NH2和—C(CH2—OH)3中选择的官能团（a）的侧链（b），并通过酰胺键或酯键引入到SMA的马来酸残基的羧基中的SMA衍生物，当引入多个侧链（b）到SMA中时，这些侧链（b）可以相同也可以不同；以及这种SMA衍生物和活性物质的共价结合物。
• POLYMERIZED DRUG-CONTAINING PHARMACEUTICAL COMPOSITION
  申请人：Biodynamic Research Foundation

  公开号：EP3453390A1

  公开（公告）日：2019-03-13

  The present invention provides a formulation having excellent solubility and/or stability of a macromolecular drug, and more specifically, a pharmaceutical composition containing a macromolecular drug, a dissolution-enhancing and/or stabilizing agent, and an aqueous solvent, wherein the dissolution-enhancing and/or stabilizing agent is at least one selected from the group consisting of (1) proteins, (2) synthetic polymers, (3) sugars or sugar alcohols, (4) inorganic salts, (5) amino acids, (6) phospholipids, (7) aliphatic alcohols, (8) medium-chain fatty acids, and (9) mucopolysaccharides.

  本发明提供了一种具有优异溶解性和/或高分子药物稳定性的制剂，更具体地说，是一种含有高分子药物、溶解促进剂和/或稳定剂以及水性溶剂的药物组合物、其中，溶出促进剂和/或稳定剂至少是选自以下组别的一种：(1) 蛋白质；(2) 合成聚合物；(3) 糖或糖醇；(4) 无机盐；(5) 氨基酸；(6) 磷脂；(7) 脂肪醇；(8) 中链脂肪酸；(9) 粘多糖。
• ELECTROCONDUCTIVE ADHESIVE COMPOSITION FOR ELECTROCHEMICAL DEVICE ELECTRODE, CURRENT COLLECTOR WITH ADHESIVE LAYER, AND ELECTRODE FOR ELECTROCHEMICAL DEVICE
  申请人：ZEON CORPORATION

  公开号：US20150203722A1

  公开（公告）日：2015-07-23

  The present invention is characterized by containing an electroconductive carbon, a water-soluble polymer, a particulate binding agent, and a dispersion medium, in which the water-soluble polymer is an isobutylene-maleic anhydride copolymer containing a structural unit (a) represented by the following general formula (I), and is partially hydrolyzed.
• METHOD OF PRODUCING STRUCTURE CONTAINING PHASE-SEPARATED STRUCTURE AND METHOD OF FORMING TOP COAT FILM
  申请人：Tokyo Ohka Kogyo Co., Ltd.

  公开号：US20150291832A1

  公开（公告）日：2015-10-15

  A method of producing a structure containing a phase-separated structure, including forming a layer containing a block copolymer on a substrate; applying a top coat material to the layer containing the block copolymer to form a top coat film; and subjecting the layer including the block copolymer having the top coat film formed thereon to annealing treatment so as to conduct a phase separation of the layer, the top coat material including an organic solvent component and a polymeric compound containing a structural unit having either a dicarboxylic acid or a salt of a dicarboxylic acid, and the organic solvent component containing water and an alcohol having 3 or more carbon atoms.
• Micro-Porous Hybrid Film Having Electro-Chemical Stability and Method for Preparing the Same
  申请人：SK INNOVATION CO., LTD.

  公开号：US20150333311A1

  公开（公告）日：2015-11-19

  Provided are a micro-porous hybrid film and a method for preparing the same, and more particularly, a micro-porous hybrid film capable of improving reliability of a battery by simultaneously improving thermal stability at a high temperature and water properties, and a method for preparing the same. In addition, the present invention relates to a micro-porous hybrid film suitable for a separator of a high capacity/high output lithium secondary battery capable of increasing production stability, long term stability, and performance of the battery by improving adhesive force between a micro-porous film and a coating layer and permeability and minimizing a water content by the coating layer.