(2,7-Dimethyl-thiazolo[4,5-d]pyridazin-4-yl)-hydrazine | 184147-61-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (2,7-Dimethyl-thiazolo[4,5-d]pyridazin-4-yl)-hydrazine
• 英文别名: (2,7-Dimethyl-[1,3]thiazolo[4,5-d]pyridazin-4-yl)hydrazine
• CAS: 184147-61-3
• 化学式: C₇H₉N₅S
• mdl: MFCD19202752
• 分子量: 195.248
• InChiKey: MWSDWEBTLXNPNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2,7-Dimethyl-thiazolo[4,5-d]pyridazin-4-yl)-hydrazine 在 吡啶 作用下， 反应 2.0h， 生成 3,5,7-Trimethyl-6-thia-1,2,3a,4,8-pentaaza-as-indacene
  参考文献：
  名称：

  Synthesis and Biological Evaluation of New Fused Thiazolo[4,5-d] Pyridazine Derivatives

  摘要：

  AbstractThe synthesis of thiazolo[4,5‐d]pyridazines and the unknown ring systems, thiazolo[4,5‐d]‐1,2,4‐triazolo‐ and tetrazolo[4,3‐b]pyridazines as well as thiazolo(4,5‐d]pyridazino[2,3‐c]2H triazines, has been achieved according to different pathways. Biological testing of the new tricyclic heterocycles revealed that some of these compounds possess remarkable antibacterial activity.

  DOI：

  10.1002/jccs.199600062
• 作为产物：
  描述：

  2,7-dimethyl-4-oxothiazolo[4,5-d]pyridazine 在 一水合肼 、 三氯氧磷 作用下， 以 乙醇 为溶剂， 反应 3.0h， 生成 (2,7-Dimethyl-thiazolo[4,5-d]pyridazin-4-yl)-hydrazine
  参考文献：
  名称：

  Synthesis and Biological Evaluation of New Fused Thiazolo[4,5-d] Pyridazine Derivatives

  摘要：

  AbstractThe synthesis of thiazolo[4,5‐d]pyridazines and the unknown ring systems, thiazolo[4,5‐d]‐1,2,4‐triazolo‐ and tetrazolo[4,3‐b]pyridazines as well as thiazolo(4,5‐d]pyridazino[2,3‐c]2H triazines, has been achieved according to different pathways. Biological testing of the new tricyclic heterocycles revealed that some of these compounds possess remarkable antibacterial activity.

  DOI：

  10.1002/jccs.199600062