Methyl (Z)-3,4-dihydroxy-4-methoxy-2-oxo-but-3-enoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Methyl (Z)-3,4-dihydroxy-4-methoxy-2-oxo-but-3-enoate
• 英文别名: dimethyl 2,3-dihydroxybut-2-enedioate
• 化学式: C₆H₈O₆
• 分子量: 176.126
• InChiKey: HMPNVUONVWQKFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  甲醇 、 dihydroxyfumaric acid 在 氯化亚砜 作用下， 反应 48.0h， 以74%的产率得到Methyl (Z)-3,4-dihydroxy-4-methoxy-2-oxo-but-3-enoate
  参考文献：
  名称：

  碱介导的级联二羟富马酸和芳香醛的级联羟醛加成和断裂反应：通过选择碱，溶剂和取代基来控制化学发散

  摘要：

  二羟基富马酸（DHF）的二酯衍生物已专门用作有机合成中的亲电子试剂。然而，烯-二醇部分中所含的DHF亲核反应性的合成效用尚未得到开发。受到最近观察到的二羟基富马酸酯的pH依赖性化学发散亲核醛醇缩合反应（DHF 2–）与乙醛酸酯和甲醛，我们在此报告二羟基富马酸酯与芳族和杂芳族醛之间碱控制的化学发散反应的控制和合成应用。在主要的水性介质中，以氢氧化物为碱，先进行羟醛加成，然后进行脱草酸作用，得到各种3-芳基-2，3-二羟基丙酸。以三乙胺为THF中的碱，1-芳基-2,3-二羟基丙烷是反应的产物。为了了解DHF，其二羧酸盐和其二甲基酯之间反应性的差异，我们进行了计算和实验研究，它们为为什么富马酸二羟基酯（DHF 2–）是亲核试剂而相应的二酯以亲电子试剂反应的原因提供了理论依据。。

  DOI：

  10.1021/acs.joc.8b01867

文献信息

• Preparation of 5-hydroxy-6-oxo-1,6-dihydropyrimidine compounds
  申请人：Dreher D. Spencer

  公开号：US20050090668A1

  公开（公告）日：2005-04-28

  5-Hydroxy-6-oxo-1,6-dihydropyrimidine compounds are prepared by the condensation of dihydroxyfumarate derivatives with amidines. The pyrimidine compounds are useful as intermediates in the preparation of pharmacologically active compounds.

  5-羟基-6-氧代-1,6-二氢嘧啶化合物是通过二羟基富马酸酯与胺基甲酸酯的缩合制备的。这些嘧啶化合物在制备药理活性化合物中作为中间体是有用的。
• Method of preparing yellow pigments
  申请人：Shakhnovich I. Alexander

  公开号：US20070089641A1

  公开（公告）日：2007-04-26

  The present invention relates to a method of preparing a yellow pigment comprising an asymmetric quinolonoquinolone in an amount greater than 5% by weight of the yellow pigment. Also disclosed are modified yellow pigments comprising this yellow pigment having attached at least one organic group as well as inkjet ink compositions comprising the yellow pigments or the modified yellow pigments.

  本发明涉及一种制备黄色颜料的方法，其中包含量大于黄色颜料重量的5%的不对称喹诺喹啉酮。还公开了包括至少一个有机基团附着的该黄色颜料的改性黄色颜料，以及包括该黄色颜料或改性黄色颜料的喷墨油墨组合物。
• SYNTHESIS OF AZA-ACENES AS NOVEL N-TYPE MATERIALS FOR ORGANIC ELECTRONICS
  申请人：Thompson Mark E.

  公开号：US20130187136A1

  公开（公告）日：2013-07-25

  Acenes, such as aza-acenes are attractive materials for organic semiconductors, specifically for n-type materials. There are disclosed new derivatives of acenes that are fabricated using novel synthesis. For example, the disclosed fabrication strategies have allowed for the first time new aza-tetracene and aza-pentacene derivatives. The HOMO and LUMO energy levels of these materials are tunable through appropriate substitution and as predicted, deepened. There are also disclosed organic photosensitive devices comprising at least one aza-acene such as aza-tetracene and aza-pentacene.

  Acenes，例如氮杂Acenes，是有机半导体材料中具有吸引力的材料，特别是用于n型材料。公开了使用新型合成制备的新衍生物。例如，公开的制备策略首次允许新的氮杂四环和氮杂五环衍生物的制备。这些材料的HOMO和LUMO能级可通过适当的取代进行调节，并且如预测的那样加深。还公开了至少包括一个氮杂Acenes（例如氮杂四环和氮杂五环）的有机光敏装置。
• Fluoroquinolonoquinolones and inkjet ink compositions comprising the same
  申请人：CABOT CORPORATION

  公开号：EP2796512A1

  公开（公告）日：2014-10-29

  The present invention relates to modified yellow pigments comprising yellow pigments having attached at least one organic group. The yellow pigment is a fluoroquinolonoquinolone pigment of formula I wherein R3 is fluorine and R1, R2 and R4 are hydrogen. Also disclosed are inkjet ink compositions comprising these modified yellow pigments and inkjet ink sets comprising these inkjet ink compositions. Other applications are also disclosed.

  本发明涉及改性黄色颜料，包括附有至少一个有机基团的黄色颜料。黄色颜料是式 I 的氟喹啉酮颜料，其中 R3 是氟，R1、R2 和 R4 是氢。还公开了包含这些改性黄色颜料的喷墨墨水组合物和包含这些喷墨墨水组合物的喷墨墨水组。还公开了其它应用。
• Epindolidione pigments
  申请人：——

  公开号：US20040138451A1

  公开（公告）日：2004-07-15

  The epindolidione compounds of the general formula (I) 1 in which A′, R 2 and A have the meanings given in claim 1, are outstanding pigments which are notable in particular for better migration, light and solvent fastnesses, better heat stability and enhanced colouring power and also better dispersibility and capability to be brought into pigment form. The invention also relates to a process for preparing these epindolidione compounds and to their use a colorants for colouring polymer compositions or paper pulps, as colorants in electrophotographic toners and developers, as colorants in ink-jet inks, as colorants in the coatings industry, as colorants for textile printing or as a printing ink in the graphical industry, as colorants in cosmetics.

  通式(I)的表吲哚二酮化合物 1 其中 A′、R 2 和 A 的含义如权利要求 1 所述、 表吲哚二酮化合物是一种出色的颜料，特别是具有更好的迁移性、耐光性和耐溶剂性，更好的热稳定性和更强的着色力，以及更好的分散性和制成颜料的能力。 本发明还涉及到制备这些表吲哚二酮化合物的工艺，以及它们在聚合物组合物或纸浆着色中作为着色剂、在电子照相调色剂和显影剂中作为着色剂、在喷墨油墨中作为着色剂、在涂料工业中作为着色剂、在纺织品印刷中作为着色剂或在制图工业中作为印刷油墨、在化妆品中作为着色剂的用途。