1-(benzyloxy)-4-(benzyloxymethyl)-2-methoxybenzene | 1448459-37-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(benzyloxy)-4-(benzyloxymethyl)-2-methoxybenzene
• 英文别名: 2-Methoxy-1-phenylmethoxy-4-(phenylmethoxymethyl)benzene；2-methoxy-1-phenylmethoxy-4-(phenylmethoxymethyl)benzene
• CAS: 1448459-37-7
• 化学式: C₂₂H₂₂O₃
• 分子量: 334.415
• InChiKey: PHZXGJHRYWADBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(benzyloxy)-4-(benzyloxymethyl)-2-methoxybenzene 在 sodium tetrahydroborate 、 nickel(II) chloride hexahydrate 作用下， 以 甲醇 为溶剂， 以90%的产率得到4-((benzyloxy)methyl)-2-methoxyphenol
  参考文献：
  名称：

  NiCl2·6H2O/NaBH4 in methanol: a mild and efficient strategy for chemoselective deallylation/debenzylation of aryl ethers

  摘要：

  Deprotection of allyl/benzyl aryl ethers was achieved chemoselectively. The mild and inexpensive reagent combination of NiCl2 center dot 6H(2)O/NaBH4 in methanol afforded the products in high yields, within a reaction time of 5-10 min. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.06.072
• 作为产物：
  描述：

  4-((benzyloxy)methyl)-2-methoxyphenol 、 溴甲苯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 生成 1-(benzyloxy)-4-(benzyloxymethyl)-2-methoxybenzene
  参考文献：
  名称：

  NiCl2·6H2O/NaBH4 in methanol: a mild and efficient strategy for chemoselective deallylation/debenzylation of aryl ethers

  摘要：

  Deprotection of allyl/benzyl aryl ethers was achieved chemoselectively. The mild and inexpensive reagent combination of NiCl2 center dot 6H(2)O/NaBH4 in methanol afforded the products in high yields, within a reaction time of 5-10 min. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.06.072

文献信息

• NiCl2·6H2O/NaBH4 in methanol: a mild and efficient strategy for chemoselective deallylation/debenzylation of aryl ethers
  作者：Mangilal Chouhan、Kapil Kumar、Ratnesh Sharma、Vikas Grover、Vipin A. Nair

  DOI：10.1016/j.tetlet.2013.06.072

  日期：2013.8

  Deprotection of allyl/benzyl aryl ethers was achieved chemoselectively. The mild and inexpensive reagent combination of NiCl2 center dot 6H(2)O/NaBH4 in methanol afforded the products in high yields, within a reaction time of 5-10 min. (C) 2013 Elsevier Ltd. All rights reserved.