3-(2-azidophenyl)-5-ethylthio-1,2,4-oxadiazole | 1352447-96-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(2-azidophenyl)-5-ethylthio-1,2,4-oxadiazole
• 英文别名: 3-(2-Azidophenyl)-5-ethylsulfanyl-1,2,4-oxadiazole；3-(2-azidophenyl)-5-ethylsulfanyl-1,2,4-oxadiazole
• CAS: 1352447-96-1
• 化学式: C₁₀H₉N₅OS
• 分子量: 247.28
• InChiKey: OCBQJBMWQLHOSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  78.6
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-(2-azidophenyl)-5-ethylthio-7-phenyl-4,1,3-oxadiazabicyclo[3.2.0]hept-2-ene 以 甲苯 为溶剂， 反应 47.0h， 以51%的产率得到3-(2-azidophenyl)-5-ethylthio-1,2,4-oxadiazole
  参考文献：
  名称：

  1,2,4-Oxadiazoles from cycloreversions of oxadiazabicyclo[3.2.0]heptenes: 1-azetines as thiocyanate equivalents

  摘要：

  1,3-Dipolar cycloaddition of nitrile oxides to 4-aryl-2-alkylthio-1-azetines gave a series of oxadiazabicyclo[3.2.0]heptenes as single diastereoisomers. Heating these cycloadducts in toluene resulted in an overall [2+2]-cycloreversion to give 5-alkylthio-3-aryl-1,2,4-oxadiazoles. In this process, the 1-azetine behaves as a thiocyanate equivalent. When the nitrile oxide substituent was 2-azidobenzene, the azide could be converted into a 1,2,3-triazole giving a (1,2,4-oxadiazolo)-(1,2,3-triazolo)-1,2-disubstituted benzene. 1,2,4-Oxadiazoles are sought after in medicinal chemistry and materials sciences. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.12.007

文献信息

• Pyridines from Azabicyclo[3.2.0]hept-2-en-4-ones through a Proposed Azacyclopentadienone
  作者：Karl Hemming、Musharraf N. Khan、Vishnu V. R. Kondakal、Arnaud Pitard、M. Ilyas Qamar、Craig R. Rice

  DOI：10.1021/ol202924s

  日期：2012.1.6

  Pyridines have been formed by heating azabicyclo[3.2.0]hept-2-en-4-ones in toluene. The generation of a 3-azacyclopentadienone intermediate via a [2 + 2]-cycloreversion Is proposed as the key step. A Diels-Alder reaction of a styrene, extrusion of carbon monoxide, and loss of hydrogen then gives the pyridine. The process parallels the well-known synthesis of benzenes from cyclopentadienones. The azabicyclo[3.2.0]hept-2-en-4-ones were synthesized from the reaction between readily available cyclopropenones and 1-azetines, In which the cyclopropenones behave as all-carbon 1,3-dipolar equivalents.
• 1,2,4-Oxadiazoles from cycloreversions of oxadiazabicyclo[3.2.0]heptenes: 1-azetines as thiocyanate equivalents
  作者：Karl Hemming、Musharraf N. Khan、Paul A. O'Gorman、Arnaud Pitard

  DOI：10.1016/j.tet.2012.12.007

  日期：2013.1

  1,3-Dipolar cycloaddition of nitrile oxides to 4-aryl-2-alkylthio-1-azetines gave a series of oxadiazabicyclo[3.2.0]heptenes as single diastereoisomers. Heating these cycloadducts in toluene resulted in an overall [2+2]-cycloreversion to give 5-alkylthio-3-aryl-1,2,4-oxadiazoles. In this process, the 1-azetine behaves as a thiocyanate equivalent. When the nitrile oxide substituent was 2-azidobenzene, the azide could be converted into a 1,2,3-triazole giving a (1,2,4-oxadiazolo)-(1,2,3-triazolo)-1,2-disubstituted benzene. 1,2,4-Oxadiazoles are sought after in medicinal chemistry and materials sciences. (c) 2012 Elsevier Ltd. All rights reserved.