N,N-dimethyl-2-(hydroxyimino)-3-oxobutanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N-dimethyl-2-(hydroxyimino)-3-oxobutanamide
• 英文别名: (2E)-2-hydroxyimino-N,N-dimethyl-3-oxobutanamide
• 化学式: C₆H₁₀N₂O₃
• 分子量: 158.157
• InChiKey: PCDLJFHTPHZVMV-FNORWQNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  70
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N,N-dimethyl-2-(hydroxyimino)-3-oxobutanamide 在 palladium on charcoal catalyst 盐酸 作用下， 以 乙醇 、 水 、 氢气 为溶剂， 生成 2,3-dihydro-N,N,5-trimethyl-2-oxo-1H-imidazole-4-carboxamide
  参考文献：
  名称：

  5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid

  摘要：

  在5位具有（取代氨基）甲基取代基的2,3-二氢-2-氧-1H-咪唑-4-羧酸衍生物中，这些化合物可用作心力衰竭药、降压药和抗血栓药。这些化合物通过适当胺与5-(溴甲基)-2,3-二氢-2-氧-1H-咪唑-4-羧酸酯或酰胺反应而得到。

  公开号：

  US04371737A1

文献信息

• 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid
  申请人：Merrell Dow Pharmaceuticals Inc.

  公开号：US04371737A1

  公开（公告）日：1983-02-01

  2,3-Dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives having a (substituted amino)methyl substituent at the 5-position, are useful as cardiotonics, antihypertensives and antithrombotic agents. The compounds are obtained by the reaction of an appropriate amine with a 5-(bromomethyl)-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid ester or amide.

  在5位具有（取代氨基）甲基取代基的2,3-二氢-2-氧-1H-咪唑-4-羧酸衍生物中，这些化合物可用作心力衰竭药、降压药和抗血栓药。这些化合物通过适当胺与5-(溴甲基)-2,3-二氢-2-氧-1H-咪唑-4-羧酸酯或酰胺反应而得到。
• 5-(4-Phenyl
  申请人：Merrell Dow Pharmaceuticals Inc.

  公开号：US04329470A1

  公开（公告）日：1982-05-11

  2,3-Dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives having a 5-(4-phenyl-1-piperidinyl)methyl substituent, are useful as cardiotonics, antihypertensives and antithrombotic agents. The compounds are obtained by the reaction of an appropriate amine with a substituted 5-bromomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivative.

  具有5-(4-苯基-1-哌啶基)甲基取代基团的2,3-二氢-2-氧代-1H-咪唑-4-羧酸衍生物，可用作心力衰竭药、降压药和抗血栓药。这些化合物是通过适当胺与取代的5-溴甲基-2,3-二氢-2-氧代-1H-咪唑-4-羧酸衍生物发生反应而获得的。
• 5-(4-Phenyl-1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0064706A1

  公开（公告）日：1982-11-17

  2,3-Dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives having a 5-(4-phenyl-1-piperidinyl)methyl substituent, are useful as cardiotonics, antihypertensives and antithrombotic agents. The compounds are obtained by the reaction of an appropriate amine with a substituted 5-bromomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivative.

  具有 5-(4-苯基-1-哌啶基)甲基取代基的 2,3-二氢-2-氧代-1H-咪唑-4-羧酸衍生物可用作强心剂、抗高血压剂和抗血栓剂。这些化合物是通过适当的胺与取代的 5-溴甲基-2,3-二氢-2-氧代-1H-咪唑-4-羧酸衍生物反应得到的。
• Novel imidazolecarboxamide derivatives
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0078546A1

  公开（公告）日：1983-05-11

  Novel imidazolecarboxamides of the following structure are useful as antiallergy agents wherein Q and T are oxygen or a divalent sulfur; R is hydrogen, C14 alkyl, C14 alkylcarbonyl or benzoyl; R1 is hydrogen, lower alkyl or CF3; R2 is NH2, -NH(Rs) or-N(R5)(R6); R5 is C14 alkyl, pyridinyl, phenyl or substituted phenyl; R6 is C14 alkyl and the pharmaceutically acceptable salts thereof.

  以下结构的新型咪唑羧酰胺可用作抗过敏剂 其中 Q 和 T 是氧或二价硫；R 是氢、C14 烷基、C14 烷基羰基或苯甲酰基；R1 是氢、低级烷基或 CF3；R2 是 NH2、-NH(Rs) 或-N(R5)(R6)；R5 是 C14 烷基、吡啶基、苯基或取代苯基；R6 是 C14 烷基及其药学上可接受的盐类。
• Method for reducing reperfusion injury with imidazol-2-thione-carboxamides
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0312960A2

  公开（公告）日：1989-04-26

  Certain 2-oxo- and 2-thioxoimidazol-4-carboxamides are reported to reduce reperfusion injury which is the injury which occurs when molecular oxygen is reintroduced into an ischemic tissue. These compounds could be used to prevent much of the damage which occurs to the heart of a heart attack victim.

  据报道，某些 2-氧代和 2-硫代咪唑-4-羧酰胺可减少再灌注损伤，这种损伤是指分子氧重新进入缺血组织时发生的损伤。这些化合物可用于预防心脏病患者心脏受到的大部分损伤。