morpholine-4-carboximidothioic acid methyl ester | 89269-30-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: morpholine-4-carboximidothioic acid methyl ester
• 英文别名: 4-(methylsulfanyl)carboximidoylmorpholine；4-Morpholinecarboximidothioic acid, methyl ester；methyl morpholine-4-carboximidothioate
• CAS: 89269-30-7
• 化学式: C₆H₁₂N₂OS
• mdl: MFCD21646887
• 分子量: 160.24
• InChiKey: VWALTDPHAMPZMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  morpholine-4-carboximidothioic acid methyl ester 、 5-(4-(4-cyanophenyl)piperidine-1-carbonyl)-4-ethyl-2-methylbenzohydrazide 在 吡啶 作用下， 反应 72.0h， 以24%的产率得到4-(1-(2-ethyl-4-methyl-5-(5-morpholino-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile
  参考文献：
  名称：

  [EN] HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS
  [FR] MODULATEURS HÉTÉROCYCLIQUES DE LA SYNTHÈSE DES LIPIDES

  摘要：

  提供了一些脂肪酸合成调节剂。这些化合物可用于治疗由于调节脂肪酸合酶功能不当而表现出的紊乱的疾病，通过调节功能和/或脂肪酸合酶途径。提供了用于治疗此类疾病的方法，包括病毒感染，如丙型肝炎感染，癌症和代谢性疾病。

  公开号：

  WO2012122391A1

文献信息

• [EN] NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES<br/>[FR] NOUVEAUX COMPOSÉS HÉTÉROARYLE-TRIAZOLE UTILISÉS COMME PESTICIDES
  申请人：BAYER AG

  公开号：WO2021069567A1

  公开（公告）日：2021-04-15

  The present invention relates to novel heteroaryl-triazole compounds of the general formula (I), in which the structural elements X, Y, R1, R2, R3a, R3b, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.

  本发明涉及一种新型杂环基三唑化合物，其一般式为（I），其中结构元素X、Y、R1、R2、R3a、R3b、R4和R5的含义如描述中所示，以及包含这些化合物的配方和组合物，用于控制包括节肢动物和昆虫在内的动物害虫，用于植物保护，并用于控制动物体表寄生虫。
• Heterocyclic Modulators of Lipid Synthesis
  申请人：Oslob Johan D.

  公开号：US20120264737A1

  公开（公告）日：2012-10-18

  Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

  提供了一些脂肪酸合成调节剂化合物。这些化合物可以通过调节功能和/或脂肪酸合成途径来治疗由脂肪酸合酶功能失调所表征的疾病。提供了治疗这些疾病的方法，包括病毒感染，如丙型肝炎感染，癌症和代谢性疾病。
• HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS
  申请人：3-V BIOSCIENCES, INC.

  公开号：US20140322355A1

  公开（公告）日：2014-10-30

  Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

  提供了一些脂肪酸合成调节剂化合物。这些化合物可以通过调节功能和/或脂肪酸合成途径来治疗特征为脂肪酸合成酶功能失调的疾病。提供了用于治疗这些疾病的方法，包括病毒感染（如丙型肝炎感染）、癌症和代谢性疾病。
• Phosphorus derivatives of carbamimidothioic esters
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0096535A1

  公开（公告）日：1983-12-21

  Phosphorous derivatives of carbamimidothioic-acid esters of the formula wherein R is an alkyl group containing 1 to 4 carbon atoms; R1 is an alkyl group containing 1 to 4 carbon atoms, an alkoxy group containing 1 to 4 carbon atoms, al alkylthio group containing 1 to 4 carbon atoms, or an amino or mono-alkylamino group containing 1 to 4 carbon atoms; R2 is an alkyl group containing 1 to 4 carbon atoms or an alkylthiolkyl group wherein each alkyl group independently contains from 1 to 4 carbon atoms; R3 is an alkyl group containing 1 to 4 carbon atoms, a phenyl, substituted phenyl, benzyl or substituted benzyl group; R' is an alkyl group containing 1 to 4 carbon atoms, a benzyl or substituted benzyl group; or RJ and R when taken together represent an alkylene group containing 4 to 6 carbon atoms which group can be straight or branched chain or a group of one of the formulae wherein A is oxygen, sulfur or -NR; X is oxygen or sulfur, Y is oxygen, sulfur or -NH with the proviso that when Y is R can also be hydrogen; that when R' is alkoxy and Y is oxygen, X is also oxygen; that when R' is alkoxy and Y is sulfur, X is also sulfur and that when R' is alkylthio, X and Y are different; as well as their preparation and use as systemic insecticides and acaricides, as well as fungicides.

  式中的氨基甲酰亚胺硫代酸酯的磷衍生物 其中 R 是含有 1 至 4 个碳原子的烷基； R1 是含 1 至 4 个碳原子的烷基、含 1 至 4 个碳原子的烷氧基、含 1 至 4 个碳原子的烷硫基或含 1 至 4 个碳原子的氨基或单烷基氨基； R2 是含有 1 至 4 个碳原子的烷基或烷硫基，其中每个烷基独立地含有 1 至 4 个碳原子； R3 是含 1 至 4 个碳原子的烷基、苯基、取代苯基、苄基或取代苄基； R' 是含有 1 至 4 个碳原子的烷基、苄基或取代苄基；或 RJ 和 R 共同代表一个含 4 至 6 个碳原子的亚烷基，该基团可以是直链或支链，也可以是下式中的一个基团 其中 A 是氧、硫或-NR； X 是氧或硫 Y是氧、硫或-NH，但当Y是 R也可以是氢；当R'是烷氧基而Y是氧时，X也是氧；当R'是烷氧基而Y是硫时，X也是硫，当R'是烷硫基时，X和Y是不同的；以及它们作为系统杀虫剂和杀螨剂以及杀真菌剂的制备和用途。
• Heterocyclic modulators of lipid synthesis
  申请人：Sagimet Biosciences Inc.

  公开号：US11034690B2

  公开（公告）日：2021-06-15

  Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

  本研究提供了脂肪酸合成调节剂化合物。通过调节脂肪酸合成酶的功能和/或脂肪酸合成酶途径，这些化合物可用于治疗以脂肪酸合成酶功能失调为特征的疾病。提供了治疗此类疾病的方法，包括病毒感染，如丙型肝炎感染、癌症和代谢紊乱，如非酒精性脂肪性肝炎（NASH）。