A novel optically active bisphosphine ligand CDP, derived from an anti head-to-head coumarin dimer: synthesis and application to the rhodium-catalyzed asymmetric hydrogenation of arylenamides
摘要:
A novel optically active bisphosphine ligand CDP containing a C-2-symmetric cyclobutane ring was prepared from an enantiopure anti head-to-head coumarin dimer. CDP was successfully applied to the rhodium-catalyzed asymmetric hydrogenation of arylenamides, affording the corresponding amides up to 93% e.e. (C) 1998 Elsevier Science Ltd. All rights reserved.
Fast Racemisation of Chiral Amines and Alcohols by Using Cationic Half-Sandwich Ruthena- and Iridacycle Catalysts
作者:Thomas Jerphagnon、Arnaudâ J.â A. Gayet、Florian Berthiol、Vincent Ritleng、NatasÌa MrsÌicÌ、Auke Meetsma、Michel Pfeffer、Adriaanâ J. Minnaard、Benâ L. Feringa、Johannesâ G. deâ Vries
DOI:10.1002/chem.200902103
日期:2009.11.23
are highly active and efficient in the racemisation of chiralalcohols and amines. Upon activation with base, these complexes are able to selectively racemise alcohols, whereas the non‐activated complexes are selective catalysts for the racemisation of amines. We have applied the iridacycles in the DKR of racemic β‐chloroalcohols to produce chiral epoxides in a biphasic system in good yields and high