(S)-3-[(R)-4,4,4-trifluoro-3-(4-methoxyphenyl)butanoyl]-4-phenylmethyloxazolidin-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (S)-3-[(R)-4,4,4-trifluoro-3-(4-methoxyphenyl)butanoyl]-4-phenylmethyloxazolidin-2-one
• 英文别名: (4S)-4-benzyl-3-[(3R)-4,4,4-trifluoro-3-(4-methoxyphenyl)butanoyl]-1,3-oxazolidin-2-one
• 化学式: C₂₁H₂₀F₃NO₄
• 分子量: 407.389
• InChiKey: PHKIFLBERPSZGJ-FUHWJXTLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (S)-4-苄基-2-唑烷酮 在 正丁基锂 、 copper(I) bromide dimethylsulfide complex 、 二甲基硫 作用下， 以 四氢呋喃 为溶剂， 反应 8.0h， 生成 (S)-3-[(R)-4,4,4-trifluoro-3-(4-methoxyphenyl)butanoyl]-4-phenylmethyloxazolidin-2-one
  参考文献：
  名称：

  Michael addition of organocopper species to 3-[(E)-4,4,4-trifluorobut-2-enoyl]oxazolidin-2-ones

  摘要：

  Investigation of Michael addition has been carried out using versatile organomagnesium or lithium reagents in the presence of copper(I) species towards chiral 3-[(E)-4,4,4-trifluorobut-2-enoyl] oxazolidin-2-ones, and it was demonstrated that this route enabled us to successfully construct optically active molecules with a CF3 moiety at the chiral center in good yields as well as the high level of diastereofacial selectivity. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-1139(99)00034-2

文献信息

• Michael addition of organocopper species to 3-[(E)-4,4,4-trifluorobut-2-enoyl]oxazolidin-2-ones
  作者：Takashi Yamazaki、Noriyasu Shinohara、Tomoya Kitazume、Shoichi Sato

  DOI：10.1016/s0022-1139(99)00034-2

  日期：1999.7

  Investigation of Michael addition has been carried out using versatile organomagnesium or lithium reagents in the presence of copper(I) species towards chiral 3-[(E)-4,4,4-trifluorobut-2-enoyl] oxazolidin-2-ones, and it was demonstrated that this route enabled us to successfully construct optically active molecules with a CF3 moiety at the chiral center in good yields as well as the high level of diastereofacial selectivity. (C) 1999 Elsevier Science S.A. All rights reserved.