1-phenyl-3-(3-methyl-4-phenylpyrazol-5-yl)thiourea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-phenyl-3-(3-methyl-4-phenylpyrazol-5-yl)thiourea
• 英文别名: 1-Phenyl-3-(3-methyl-4-phenylpyrazol-5-yl) thiourea；1-(5-methyl-4-phenyl-1H-pyrazol-3-yl)-3-phenylthiourea
• 化学式: C₁₇H₁₆N₄S
• 分子量: 308.407
• InChiKey: YGWQBEIOYFSLRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  84.8
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-甲基-4-苯基-2H-吡唑-3-胺 、 硫代异氰酸苯酯 以 吡啶 为溶剂， 反应 6.0h， 以80%的产率得到1-phenyl-3-(3-methyl-4-phenylpyrazol-5-yl)thiourea
  参考文献：
  名称：

  Reactions with heterocyclic amidines, VII: Synthesis of some new pyrazolo[1,5-c]-1,2,4-triazines, pyrazolo[1,5-a]-1,3,5-triazines and pyrazolo[1,5-a]pyrimidines

  摘要：

  DOI：

  10.1007/bf00911090

文献信息

• ELNAGDI M. H.; ZAYED E. M.; KHALIFA M. A. E.; GHOZIAN S. A., MONATSH. CHEM., 1981, 112, NO 2, 245-252
  作者：ELNAGDI M. H.、 ZAYED E. M.、 KHALIFA M. A. E.、 GHOZIAN S. A.

  DOI：——

  日期：——
• CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES
  申请人：Sheridan Joseph M.

  公开号：US20140031547A1

  公开（公告）日：2014-01-30

  The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (CK1δ) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.
• CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS TAUOPATHIES
  申请人：Electrophoretics Limited

  公开号：US20160354375A1

  公开（公告）日：2016-12-08

  The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (CK1δ) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.
• Reactions with heterocyclic amidines, VII: Synthesis of some new pyrazolo[1,5-c]-1,2,4-triazines, pyrazolo[1,5-a]-1,3,5-triazines and pyrazolo[1,5-a]pyrimidines
  作者：Mohamed Hilmy Elnagdi、Ezzat M. Zayed、M. A. Elsayed Khalifa、Said A. Ghozlan

  DOI：10.1007/bf00911090

  日期：1981.2