5,7-二十二碳二炔二酸 | 178560-65-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 5,7-二十二碳二炔二酸
• 英文名称: 5,7-Docosadiynoic acid
• 英文别名: docosa-5,7-diynoic acid
• CAS: 178560-65-1
• 化学式: C₂₂H₃₆O₂
• 分子量: 332.5
• InChiKey: KTCYROIQAAHHIE-UHFFFAOYSA-N

物化性质

• 熔点：
  68-69°C
• 溶解度：
  氯仿（微溶）、乙酸乙酯（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  24
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  ganglioside G_M1 、 水 在 水 、 ganglioside G_M1 、 丁二炔 作用下， 生成 5,7-二十二碳二炔二酸 、
  参考文献：
  名称：

  Nucleic acid-coupled colorimetric analyte detectors

  摘要：

  本发明涉及用于直接检测生物高分子材料中颜色变化来检测分析物和膜构象变化的方法和组合物。特别地，本发明提供了使用核酸配体在聚二炔脂质体表面和相关分子层系统上的颜色测定法来直接检测分析物的方法。

  公开号：

  US06306598B1

文献信息

• Nucleic acid-coupled colorimetric analyte detectors
  申请人：Regents of the University of California

  公开号：US06306598B1

  公开（公告）日：2001-10-23

  The present invention relates to methods and compositions for the direct detection of analytes and membrane conformational changes through the detection of color changes in biopolymeric materials. In particular, the present invention provide for the direct colorimetric detection of analytes using nucleic acid ligands at surfaces of polydiacetylene liposomes and related molecular layer systems.

  本发明涉及用于直接检测生物高分子材料中颜色变化来检测分析物和膜构象变化的方法和组合物。特别地，本发明提供了使用核酸配体在聚二炔脂质体表面和相关分子层系统上的颜色测定法来直接检测分析物的方法。
• Cells Containing a Nanopatch Sensor in Their Membrane
  申请人：Jelinek Raz

  公开号：US20070275433A1

  公开（公告）日：2007-11-29

  The present invention provides isolated cells comprising nanopatch sensors integrated into the cell membrane thereof, wherein said sensors are provided in the form of perturbation-sensitive constructs, and wherein said perturbation-sensitive constructs respond to perturbations of the cell membrane by means of a detectable change in one or more physical or chemical properties associated with said construct.

  本发明提供了包含纳米贴片传感器的孤立细胞，其中所述传感器集成到其细胞膜中，在所述传感器中以感扰敏构造的形式提供，并且所述感扰敏构造通过与所述构造相关的一个或多个物理或化学特性的可检测变化来响应细胞膜的扰动。
• POLY(METHYL METHACRYLATE)-SUPPORTED POLYDIACETYLENE FILMS AS COLORIMETRIC AND/OR FLUORESCENT DETECTORS
  申请人：B.G. NEGEV TECHNOLOGIES & APPLICATIONS LTD. AT BEN-GURION UNIVERSITY

  公开号：US20160041102A1

  公开（公告）日：2016-02-11

  Colorimetric and/or fluorescent detectors, which include a polydiacetylene (PDA) film deposited on a polymethylmetacrylate (PMMA) substrate. There are also colorimetric and/or fluorescent detectors which have a solid organic matrix comprising one or more PDAs deposited on the PMMA substrate, wherein the PDA includes polymerized units of one or more diacetylene monomers, and wherein the matrix further comprises at least one recognition element of an analyte. There are also methods for detecting analytes using this detector, uses thereof and a methods for its preparation.

  颜色计量和/或荧光检测器，包括沉积在聚甲基丙烯酸甲酯（PMMA）基板上的聚二烯烃（PDA）薄膜。还有一些颜色计量和/或荧光检测器，其具有包括沉积在PMMA基板上的一个或多个PDA的固体有机基质，其中PDA包括一个或多个二烯基单体的聚合单元，且基质进一步包括至少一种分析物的识别元素。还有使用该检测器检测分析物的方法，其用途以及其制备方法。
• Nano-scaled dendrimer-based colorimetric biosensors
  申请人：Michigan Molecular Institute

  公开号：EP1243610A1

  公开（公告）日：2002-09-25

  Molecular chemical and/or biological sensors that exhibit a very high density of sensing functionality and which are applicable to a wide variety of different analytes, and enable rapid, convenient and economical detection of analytes are prepared by reacting a dendritic polymer with a diacetylene reagent wherein the diacetylene functional groups are subsequently intramolecularly polymerized to form segments having alternating conjugated double and triple bonds. Sensory groups that can bind with an analyte are bonded to the acetylene monomer units to form molecular sensors that produce observable and measurable color changes when an analyte binds with the sensory groups.

  分子化学和/或生物传感器具有极高的传感功能密度，适用于多种不同的分析物，可对分析物进行快速、方便和经济的检测，其制备方法是将树枝状聚合物与二乙炔试剂反应，二乙炔官能团随后在分子内聚合，形成具有交替共轭双键和三键的片段。可与分析物结合的感官基团与乙炔单体单元结合，形成分子传感器，当分析物与感官基团结合时，传感器会产生可观察和测量的颜色变化。
• Poly(methyl methacrylate)-supported polydiacetylene films as colorimetric and/or fluorescent detectors
  申请人：B.G. NEGEV TECHNOLOGIES & APPLICATIONS LTD. AT BEN-GURION UNIVERSITY

  公开号：US10101277B2

  公开（公告）日：2018-10-16

  Colorimetric and/or fluorescent detectors, which include a polydiacetylene (PDA) film deposited on a polymethylmetacrylate (PMMA) substrate. There are also colorimetric and/or fluorescent detectors which have a solid organic matrix comprising one or more PDAs deposited on the PMMA substrate, wherein the PDA includes polymerized units of one or more diacetylene monomers, and wherein the matrix further comprises at least one recognition element of an analyte. There are also methods for detecting analytes using this detector, uses thereof and a methods for its preparation.

  比色和/或荧光检测器，包括沉积在聚甲基丙烯酸甲酯（PMMA）基板上的聚二乙烯（PDA）薄膜。还有比色和/或荧光检测器，其固体有机基质包括沉积在 PMMA 基质上的一个或多个 PDA，其中 PDA 包括一个或多个二乙炔单体的聚合单元，基质还包括至少一个分析物的识别元素。此外，还有使用这种检测器检测分析物的方法、其用途及其制备方法。