3-(4-Hydroxy-phenyl)-2-phenylacetylamino-propionic acid methyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(4-Hydroxy-phenyl)-2-phenylacetylamino-propionic acid methyl ester
• 英文别名: Methyl 3-(4-hydroxyphenyl)-2-[(2-phenylacetyl)amino]propanoate
• 化学式: C₁₈H₁₉NO₄
• 分子量: 313.353
• InChiKey: VNVRBDDZSYIUJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苯乙酰氯 在 sodium carbonate 作用下， 以 乙腈 为溶剂， 反应 86.0h， 生成 3-(4-Hydroxy-phenyl)-2-phenylacetylamino-propionic acid methyl ester
  参考文献：
  名称：

  3-Acyl-1,3-diaryltriazenes as neutral and selective acylating agents

  摘要：

  New 3-acyl-1,3-diaryltriazenes have been prepared and their reactions with amino compounds have been studied. Reactions proceed rapidly under mild conditions to give the corresponding N-acyl products: Reagents enable chemoselective acylation of aliphatic primary and secondary amines in the presence of other acylable functional groups. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01358-2

文献信息

• PHENYL-CONTAINING N-ACYL AMINE AND AMINOACID DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF, A PHARMACEUTICAL COMPOSITION AND THE USE THEREOF
  申请人：Obschestvo S Ogranichennoi Otvetstennostiyu "Pharmenterprises"

  公开号：EP1876169A1

  公开（公告）日：2008-01-09

  The present invention relates to novel phenyl-N-acyl derivatives of biogenic amines and amino acids of general formula (I) as cyclooxynease inhibitors, possessing analgetic and anti-inflammatory properties and devoid of side effects in particular ulcerogeneity and pro-spasmodic actions, as well as capability to potentiate effect of other analgetics, and possessing in addition antihypoxic, antidepressant and anti-Parkinsonistic action; as well as to the processes for the preparation novel and known phenyl-N-acyl derivatives of biogenic amines, to a pharmaceutical composition and to an agent comprising compounds of general formula (I) as well as to use thereof and a method of treating.

  本发明涉及作为环氧化酶抑制剂的通式（I）生物胺和氨基酸的新型苯基-N-酰基衍生物，该衍生物具有镇痛和抗炎特性，无副作用，特别是无溃疡性和促痉挛作用，并能增强其他镇痛药的效果，此外还具有抗缺氧、抗抑郁和抗帕金森病作用；以及生物胺的新型和已知苯基-N-酰基衍生物的制备工艺、药物组合物和包含通式（I）化合物的制剂及其用途和治疗方法。
• Phenyl-containing n-acyl amine and aminoacid derivatives, methods for the production thereof, a pharmaceutical composition and the use thereof
  申请人：Nebolsin Vladimir Evgenievich

  公开号：US20090111874A1

  公开（公告）日：2009-04-30

  The present invention relates to novel phenyl-N-acyl derivatives of biogenic amines and amino acids of general formula (I) as cyclooxynease inhibitors, possessing analgetic and anti-inflammatory properties and devoid of side effects in particular ulcerogeneity and pro-spasmodic actions, as well as capability to potentiate effect of other analgetics, and possessing in addition antihypoxic, antidepressant and anti-Parkinsonistic action; as well as to the processes for the preparation novel and known phenyl-N-acyl derivatives of biogenic amines, to a pharmaceutical composition and to an agent comprising compounds of general formula (I) as well as to use thereof and a method of treating.
• PHENYL-N-ACYL DERIVATIVES OF AMINES AND AMINO ACIDS, A PROCESS FOR THE PREPARATION THEREOF, A PHARMACEUTICAL COMPOSITION AND USE THEREOF
  申请人：Obschestvo S Ogranichennoi Otvetstvennostiyu

  公开号：US20130109880A1

  公开（公告）日：2013-05-02

  The present invention relates to novel phenyl-N-acyl derivatives of biogenic amines and amino acids of general formula (I) as cyclooxynease inhibitors, possessing analgetic and anti-inflammatory properties and devoid of side effects in particular ulcerogeneity and pro-spasmodic actions, as well as capability to potentiate effect of other analgetics, and possessing in addition antihypoxic, antidepressant and anti-Parkinsonistic action; as well as to the processes for the preparation novel and known phenyl-N-acyl derivatives of biogenic amines, to a pharmaceutical composition and to an agent comprising compounds of general formula (I) as well as to use thereof and a method of treating.
• US8309766B2
  申请人：——

  公开号：US8309766B2

  公开（公告）日：2012-11-13
• US8546612B2
  申请人：——

  公开号：US8546612B2

  公开（公告）日：2013-10-01