2-(6-methoxybenzo[d]thiazol-2-yl)isoindoline-1,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(6-methoxybenzo[d]thiazol-2-yl)isoindoline-1,3-dione
• 英文别名: N-(6-methoxy-benzothiazol-2-yl)-phthalimide；2-(6-Methoxy-1,3-benzothiazol-2-yl)isoindole-1,3-dione
• 化学式: C₁₆H₁₀N₂O₃S
• 分子量: 310.333
• InChiKey: DHKKAIFDHMMGOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  87.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氨基-6-甲氧基苯并噻唑 在 potassium acetate 、 乙酸酐 作用下， 以 四氢呋喃 为溶剂， 生成 2-(6-methoxybenzo[d]thiazol-2-yl)isoindoline-1,3-dione
  参考文献：
  名称：

  Augustin,M.; Kuppe,K.R., Zeitschrift fur Chemie, 1974, vol. 14, p. 306 - 308

  摘要：

  DOI：

文献信息

• An efficient green synthesis of new benzothiazoles containing sulfonamide or cyclic imide moieties
  作者：Chafika Bougheloum、Sabrina Alioua、Robila Belghiche、Nesma Benali、Abdelrani Messalhi

  DOI：10.1002/jhet.3753

  日期：2020.1

  An efficient and convenient protocol for the one‐pot synthesis of new benzothiazoles bearing sulfonamide or cyclic imide moieties using Cesium salt of Wells‐Dawson heteropolyacid (Cs5HP2W18O62) as solid catalyst and water as solvent under ultrasound irradiation was reported. The reaction speed was remarkably catalyzed with the aid of ultrasound irradiation. Moreover, this approach prepares multiple

  报道了在Wells-Dawson杂多酸铯盐（Cs 5 HP 2 W 18 O 62）作为固体催化剂和水作为溶剂在超声辐射下单锅合成带有磺酰胺或环状酰亚胺部分的新型苯并噻唑的有效简便方法。。借助超声辐照显着地催化了反应速度。此外，这种方法还带来了许多其他好处，例如操作简便，更高的产量和能源性能。
• [EN] BENZOTHIAZOLE AND THIAZOLE'5,5-B!PYRIDINE COMPOSITIONS AND THEIR USE AS UBIQUITIN LIGASE INHIBITORS<br/>[FR] COMPOSITIONS DE BENZOTHIAZOLE ET DE THIAZOLE'5,5-B!PYRIDINE ET LEUR UTILISATION COMME INHIBITEURS DE L'UBIQUITINE LIGASE
  申请人：RIGEL PHARMACEUTICALS INC

  公开号：WO2005037845A1

  公开（公告）日：2005-04-28

  This invention describes compounds and pharmaceutical compositions useful as ubiquitin agent inhibitors. The compounds and pharmaceutical compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. The invention also comprises the use of the compounds and pharmaceutical compositions of the invention for the treatment of conditions that require inhibition of ubiquitination. Furthermore, the invention comprises methods of inhibiting ubiquitination in a cell comprising contacting a cell in which inhibition of ubiquitination is desired with a pharmaceutical composition according to the invention.

  这项发明描述了化合物和制药组合物，作为泛素代理抑制剂。该发明的化合物和制药组合物作为抑制泛素化参与的生物化学途径的抑制剂是有用的。该发明还包括使用该发明的化合物和制药组合物治疗需要抑制泛素化的情况。此外，该发明还包括通过使用该发明的制药组合物接触需要抑制泛素化的细胞来抑制细胞内泛素化的方法。
• Benzothiazole compositions and their use as ubiquitin ligase inhibitors
  申请人：Ramesh V. Usha

  公开号：US20050130974A1

  公开（公告）日：2005-06-16

  This invention describes compounds and pharmaceutical compositions useful as ubiquitin agent inhibitors. The compounds and pharmaceutical compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. The invention also comprises the use of the compounds and pharmaceutical compositions of the invention for the treatment of conditions that require inhibition of ubiquitination. Furthermore, the invention comprises methods of inhibiting ubiquitination in a cell comprising contacting a cell in which inhibition of ubiquitination is desired with a pharmaceutical composition according to the invention.

  本发明描述了化合物和药物组合物，可用作泛素代理抑制剂。本发明的化合物和药物组合物可用作生物体中涉及泛素化的生化途径的抑制剂。本发明还包括使用本发明的化合物和药物组合物治疗需要抑制泛素化的疾病的方法。此外，本发明还包括通过将本发明的药物组合物接触到需要抑制泛素化的细胞中来抑制细胞泛素化的方法。
• Benzothniazole compositions and their use as ubiquition ligation inhibitors
  申请人：Ramesh V. Usha

  公开号：US20080039629A1

  公开（公告）日：2008-02-14

  This invention describes compounds and pharmaceutical compositions useful as ubiquitin agent inhibitors. The compounds and pharmaceutical compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. The invention also comprises the use of the compounds and pharmaceutical compositions of the invention for the treatment of conditions that require inhibition of ubiquitination. Furthermore, the invention comprises methods of inhibiting ubiquitination in a cell comprising contacting a cell in which inhibition of ubiquitination is desired with a pharmaceutical composition according to the invention.

  本发明描述了化合物和药物组合物，作为泛素剂抑制剂。本发明的化合物和药物组合物可用作生物体中泛素化参与的生化途径的抑制剂。本发明还包括使用本发明的化合物和药物组合物治疗需要抑制泛素化的疾病的方法。此外，本发明还包括抑制细胞中泛素化的方法，其中包括将需要抑制泛素化的细胞与本发明的药物组合物接触。
• BENZOTHIAZOLE AND THIAZOLE'5,5-B!PYRIDINE COMPOSITIONS AND THEIR USE AS UBIQUITIN LIGASE INHIBITORS
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：EP1680431A1

  公开（公告）日：2006-07-19