2-Azaniumyl-5-oxohexanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Azaniumyl-5-oxohexanoate
• 英文别名: 2-azaniumyl-5-oxohexanoate
• 化学式: C6H11NO3
• mdl: MFCD23974180
• 分子量: 145.16
• InChiKey: KSIJECNNZVKMJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.5
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  80.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二甲胺 、 DL-谷氨酸 生成 2-Azaniumyl-5-oxohexanoate
  参考文献：
  名称：

  BAYSSE, FRANCIS

  摘要：

  DOI：

文献信息

• [EN] ANTI-INFLUENZA COMPOSITIONS AND METHODS<br/>[FR] COMPOSITIONS ANTI-GRIPPE ET PROCÉDÉS ASSOCIÉS
  申请人：BIOCRYST PHARM INC

  公开号：WO2014186465A1

  公开（公告）日：2014-11-20

  Disclosed are novel compounds comprising an imino-ribose derivative covalently linked to a carbocycle or heterocycle. Pharmaceutical compositions comprising the compounds of the invention are also described. Methods of inhibition, treatment and/or suppression of viral infections with the compounds of the invention are also described. The compositions or methods may optionally comprise one or more additional anti-viral agents.

  揭示了一种新颖的化合物，包括一种亚胺-核糖衍生物与一个碳环或杂环共价连接。还描述了包括该发明化合物的药物组合物。还描述了使用该发明化合物抑制、治疗和/或抑制病毒感染的方法。这些组合物或方法可以选择性地包括一种或多种额外的抗病毒药物。
• [EN] MULTICYCLIC PEPTIDES AND METHODS FOR THEIR PREPARATION<br/>[FR] PEPTIDES MULTICYCLIQUES ET LEURS PROCÉDÉS DE PRÉPARATION
  申请人：STICHTING TECHNISCHE WETENSCHAPPEN

  公开号：WO2018106112A1

  公开（公告）日：2018-06-14

  The invention relates to methods for preparing a compound comprising a peptide attached to a molecular scaffold whereby multiple peptide loops are formed, to compounds that can be obtained with such methods and uses thereof.

  这项发明涉及制备一种包括肽附着在分子支架上的化合物的方法，从而形成多个肽环，以及可以通过这些方法获得的化合物及其用途。
• [EN] A HOST CELL MODIFIED TO PRODUCE LACTAMS<br/>[FR] CELLULE HÔTE MODIFIÉE POUR PRODUIRE DES LACTAMES
  申请人：UNIV CALIFORNIA

  公开号：WO2017214159A1

  公开（公告）日：2017-12-14

  The present invention provides for a genetically modified host cell capable of producing a lactam comprising a 2-pyrrolidone synthase, or an enzymatically active fragment thereof, heterologous to the host cell.

  本发明提供了一种基因改造宿主细胞，能够产生一种内酰胺，其中包括一种对宿主细胞异源的2-吡咯烷酮合成酶或其酶活性片段。
• Substituted imidazotriazinones
  申请人：——

  公开号：US20020198377A1

  公开（公告）日：2002-12-26

  The present invention relates to new substituted imidazotriazinones, processes for their preparation, and their use for the production of medicaments, in particular for improving perception, concentration power, learning power and/or memory power.

  本发明涉及新的取代咪唑三嗪酮化合物，其制备方法，以及它们用于生产药物，特别是用于改善感知能力、集中力、学习能力和/或记忆力的用途。
• [EN] CYCLIC PEPTIDES FOR PROTECTION AGAINST RESPIRATORY SYNCYTIAL VIRUS<br/>[FR] PEPTIDES CYCLIQUES POUR LA PROTECTION CONTRE LE VIRUS RESPIRATOIRE SYNCYTIAL
  申请人：VIROMETIX AG

  公开号：WO2018229156A1

  公开（公告）日：2018-12-20

  The present invention relates to a cyclic peptide, a conjugate comprising said cyclic peptide and a lipopeptide building block, a bundle of said conjugates, a synthetic virus-like particle comprising at least one bundle of conjugates and pharmaceutical compositions comprising the same. The present invention further relates to said cyclic peptide, said conjugate said bundle of conjugates, said synthetic virus-like particle and said pharmaceutical compositions for use as a medicament, preferably for use in a method for preventing of an infectious disease or reducing the risk of an infectious disease, more preferably for use in a method for preventing or reducing the risk of an infectious disease associated with or caused by a respiratory syncytial virus. In particular, the present invention relates to a cyclic peptide, wherein said cyclic peptide comprises an amino acid sequence (I), wherein said amino acid sequence (I) comprises the following amino acid sequence: X1-X2-X3-C4-X5-X6-X7-C8-X9-X10-X11-P12-I13-T14-N15-D16-Q17-K18-K19-L20-C21- X22-X23-X24-C25-X26-X27-X28-X29-X30 (SEQ ID NO: 1), wherein X1, X2, X3, X5, X6, X7, X9, X10, X11, X22, X23, X24, X26, X27, X28 and X29 are independently of each other an amino acid; C4, C8, C21 and C25 are independently of each other cysteine; P12 is proline; I13 is isoleucine; T14 is threonine; N15 is asparagine; D16 is aspartic acid; Q17 is glutamine; K18 and K19 are independently of each other lysine; L20 is leucine; and X30 is an amino acid or a deletion, wherein said cysteines C4 and C25 form a first disulfide bond and said cysteines C8 and C21 form a second disulfide bond.

  本发明涉及一种环肽，一种包含所述环肽和脂肽肽基的结合物，一束所述结合物，一种合成的类病毒颗粒，其中包括至少一个结合物束以及包含它们的制药组合物。本发明还涉及该环肽，该结合物，该结合物束，该合成的类病毒颗粒和该制药组合物作为药物的用途，优选用于预防传染病或降低传染病风险的方法，更优选用于预防或降低与呼吸道合胞病毒相关或由其引起的传染病的方法。特别地，本发明涉及一种环肽，其中所述环肽包括氨基酸序列(I)，其中所述氨基酸序列(I)包括以下氨基酸序列：X1-X2-X3-C4-X5-X6-X7-C8-X9-X10-X11-P12-I13-T14-N15-D16-Q17-K18-K19-L20-C21-X22-X23-X24-C25-X26-X27-X28-X29-X30(SEQ ID NO:1)，其中X1、X2、X3、X5、X6、X7、X9、X10、X11、X22、X23、X24、X26、X27、X28和X29分别是氨基酸；C4、C8、C21和C25分别是半胱氨酸；P12是脯氨酸；I13是异亮氨酸；T14是苏氨酸；N15是天冬氨酸；D16是天冬酸；Q17是谷氨酰胺；K18和K19分别是赖氨酸；L20是亮氨酸；X30是氨基酸或缺失，其中所述半胱氨酸C4和C25形成第一二硫键，所述半胱氨酸C8和C21形成第二二硫键。