Bicyclo(2.2.1)hept-2-ene-5-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Bicyclo(2.2.1)hept-2-ene-5-carboxamide
• 英文别名: (1R,4R)-bicyclo[2.2.1]hept-5-ene-2-carboxamide
• 化学式: C₈H₁₁NO
• 分子量: 137.181
• InChiKey: ZTUUVDYQBLRAAC-JEAXJGTLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Bicyclo(2.2.1)hept-2-ene-5-carboxamide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以54%的产率得到5-aminomethylbicyclo[2.2.1]hept-2-ene
  参考文献：
  名称：

  Polycondensation of Polymer Brushes via DNA Hybridization

  摘要：

  Triblock copolymer brushes were functionalized with nucleic acid sequences, which allowed the polymers to connect head-to-tail and form supramolecular nanostructures. Two approaches were designed and implemented, using either a palindromic DNA attached to both ends of the polymer or two different DNA sequences attached regiospecifically. Given appropriate conditions, the DNA-brush conjugates self-assembled to form either nanoworms with length up to several microns or cross-linked networks. This process is analogous to the step-growth polymerization of small molecule monomers.

  DOI：

  10.1021/ja504790r
• 作为产物：
  描述：

  bicyclo[2.2.1]hept-5-ene-2-carboxylic acid N-succinimide ester 在 ammonium hydroxide 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以95%的产率得到Bicyclo(2.2.1)hept-2-ene-5-carboxamide
  参考文献：
  名称：

  Polycondensation of Polymer Brushes via DNA Hybridization

  摘要：

  Triblock copolymer brushes were functionalized with nucleic acid sequences, which allowed the polymers to connect head-to-tail and form supramolecular nanostructures. Two approaches were designed and implemented, using either a palindromic DNA attached to both ends of the polymer or two different DNA sequences attached regiospecifically. Given appropriate conditions, the DNA-brush conjugates self-assembled to form either nanoworms with length up to several microns or cross-linked networks. This process is analogous to the step-growth polymerization of small molecule monomers.

  DOI：

  10.1021/ja504790r

文献信息

• Polycondensation of Polymer Brushes via DNA Hybridization
  作者：Xueguang Lu、Eleanor Watts、Fei Jia、Xuyu Tan、Ke Zhang

  DOI：10.1021/ja504790r

  日期：2014.7.23

  Triblock copolymer brushes were functionalized with nucleic acid sequences, which allowed the polymers to connect head-to-tail and form supramolecular nanostructures. Two approaches were designed and implemented, using either a palindromic DNA attached to both ends of the polymer or two different DNA sequences attached regiospecifically. Given appropriate conditions, the DNA-brush conjugates self-assembled to form either nanoworms with length up to several microns or cross-linked networks. This process is analogous to the step-growth polymerization of small molecule monomers.