摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

XK-469 free acid, (R)- | 157542-91-1

中文名称
——
中文别名
——
英文名称
XK-469 free acid, (R)-
英文别名
(2R)-2-[4-(7-chloroquinoxalin-2-yl)oxyphenoxy]propanoic acid
XK-469 free acid, (R)-化学式
CAS
157542-91-1
化学式
C17H13ClN2O4
mdl
——
分子量
344.7
InChiKey
NUQZXROIVGBRGR-SNVBAGLBSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    3.6
  • 重原子数:
    24
  • 可旋转键数:
    5
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.12
  • 拓扑面积:
    81.5
  • 氢给体数:
    1
  • 氢受体数:
    6

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    XK-469 free acid, (R)- 以96的产率得到XK 469
    参考文献:
    名称:
    (2-quinoxalinyloxy) phenoxypropanoic acids and related derivatives as
    摘要:
    本发明涉及(2-喹喹啉氧基)苯氧基丙酸及其相关衍生物、对映异构体和二对映异构体形式、对映异构体和二对映异构体形式的混合物以及其药学上可接受的盐形式,含有它们的药物组合物,其制备过程以及将其用于治疗哺乳动物,特别是实体瘤的方法。
    公开号:
    US05696119A1
  • 作为产物:
    描述:
    XK469 以30的产率得到XK-469 free acid, (R)-
    参考文献:
    名称:
    (2-quinoxalinyloxy) phenoxypropanoic acids and related derivatives as
    摘要:
    本发明涉及(2-喹喹啉氧基)苯氧基丙酸及其相关衍生物、对映异构体和二对映异构体形式、对映异构体和二对映异构体形式的混合物以及其药学上可接受的盐形式,含有它们的药物组合物,其制备过程以及将其用于治疗哺乳动物,特别是实体瘤的方法。
    公开号:
    US05696119A1
点击查看最新优质反应信息

文献信息

  • WO9413647A1
    申请人:——
    公开号:——
    公开(公告)日:——
  • LOCAL TREATMENT OF NEUROFIBROMAS
    申请人:Chen Ruihong
    公开号:US20090118240A1
    公开(公告)日:2009-05-07
    A method for treating a neurofibroma, e.g. dermal neurofibroma, a subdermal neurofibroma, or a superficial plexiform neurofibroma, in a subject in need of such treatment is disclosed. The method comprises locally applying a composition to a neurofibroma either topically or intralesionally. This method does not encompass systemic administration of the composition to the subject to have an effect on the neurofibromas. Compositions useful for such treatments and methods of preparing the compositions are disclosed.
  • US8211875B2
    申请人:——
    公开号:US8211875B2
    公开(公告)日:2012-07-03
  • US8487004B2
    申请人:——
    公开号:US8487004B2
    公开(公告)日:2013-07-16
  • MULTITARGET NUCLEAR RECEPTOR LIGANDS BASED ON 2-(4-(QUINOLIN-2-YLOXY)PHENOXY)PROPANOIC ACID AND 2-(4-(QUINOXALIN-2-YLOXY)PHENOXY)PROPANOIC ACID FOR THE TREATMENT OF METABOLIC AND LIVER DISEASES
    申请人:[en]CHARLES UNIVERSITY, FACULTY OF PHARMACY IN HRADEC KRALOVE
    公开号:WO2024132001A1
    公开(公告)日:2024-06-27
    1. A compound of general formula (I) wherein L1is either aryl or 6-membered heteroaryl, which optionally further includes a heteroatom selected from N, O, and S; L2is aryl, 5 or 6-membered heteroaryl containing 1 or 2 heteroatoms selected from N, O and S; or C5-C6 cycloalkyl; R1is H or independently selected from the group consisting of C1-C2 alkyl, C1-C2 haloalkyl, wherein each of these substituents may optionally be further substituted by one or more substituents selected from the group consisting of halogen, pseudohalogen, hydroxy, amino, or alkyloxy moieties; R2is H or independently selected from the group consisting of C1-C4 alkyl, C1-C4 haloalkyl, wherein each of these substituents may optionally be further substituted by one or more substituents selected from the group consisting of halogen, pseudohalogen, hydroxy, amino, or alkyloxy moieties; R3is H or independently selected from the group consisting of halogen, pseudohalogen, C1-C2 alkyl, C1-C2 haloalkyl, hydroxy or amino moieties; R4is H or independently selected from the group consisting of halogen, pseudohalogen, C1-C2 alkyl, C1-C2 haloalkyl, methoxy C1-C4 alkyl, thio C1-C4 alkyl, halogen, pseudohalogen, wherein each of these substituents may optionally be further substituted by halogen, pseudohalogen, hydroxy, or amino moiety; R5is H or independently selected from the one or two groups consisting of C1-C4 alkyl, C1-C4 haloalkyl, methoxy C1-C4 alkyl, thio C1-C4 alkyl, halogen, pseudohalogen, wherein each of these substituents may optionally be further substituted by halogen, pseudohalogen, hydroxy, nitro, or amino moiety; R6is H or independently selected from C1-C6 alkyl, C1-C4 haloalkyl, methoxy Cl- C4 alkyl, thio C1-C4 alkyl, wherein each of these substituents may optionally be further substituted by halogen, pseudohalogen, hydroxy, nitro, or amino moiety; Y is O, C, N, or S; and n is 0, 1 or 2, as well as any isomers, including geometric, tautomeric and optical forms, as well as mixtures of isomers, including racemic mixtures, and pharmaceutically acceptable derivatives and solvates thereof, for use, as a compound dually acting on two nuclear receptors in prevention or treatment of conditions which are mediated by the action, or by loss of action, of PPARα, PPARγ or FXR receptors or their endogenous ligands, and/or by excessive stimulation of LXRα.
查看更多

同类化合物

(βS)-β-氨基-4-(4-羟基苯氧基)-3,5-二碘苯甲丙醇 (S)-(-)-7'-〔4(S)-(苄基)恶唑-2-基]-7-二(3,5-二-叔丁基苯基)膦基-2,2',3,3'-四氢-1,1-螺二氢茚 (S)-盐酸沙丁胺醇 (S)-3-(叔丁基)-4-(2,6-二甲氧基苯基)-2,3-二氢苯并[d][1,3]氧磷杂环戊二烯 (S)-2,2'-双[双(3,5-三氟甲基苯基)膦基]-4,4',6,6'-四甲氧基联苯 (S)-1-[3,5-双(三氟甲基)苯基]-3-[1-(二甲基氨基)-3-甲基丁烷-2-基]硫脲 (R)富马酸托特罗定 (R)-(-)-盐酸尼古地平 (R)-(+)-7-双(3,5-二叔丁基苯基)膦基7''-[((6-甲基吡啶-2-基甲基)氨基]-2,2'',3,3''-四氢-1,1''-螺双茚满 (R)-3-(叔丁基)-4-(2,6-二苯氧基苯基)-2,3-二氢苯并[d][1,3]氧杂磷杂环戊烯 (R)-2-[((二苯基膦基)甲基]吡咯烷 (N-(4-甲氧基苯基)-N-甲基-3-(1-哌啶基)丙-2-烯酰胺) (5-溴-2-羟基苯基)-4-氯苯甲酮 (5-溴-2-氯苯基)(4-羟基苯基)甲酮 (5-氧代-3-苯基-2,5-二氢-1,2,3,4-oxatriazol-3-鎓) (4S,5R)-4-甲基-5-苯基-1,2,3-氧代噻唑烷-2,2-二氧化物-3-羧酸叔丁酯 (4-溴苯基)-[2-氟-4-[6-[甲基(丙-2-烯基)氨基]己氧基]苯基]甲酮 (4-丁氧基苯甲基)三苯基溴化磷 (3aR,8aR)-(-)-4,4,8,8-四(3,5-二甲基苯基)四氢-2,2-二甲基-6-苯基-1,3-二氧戊环[4,5-e]二恶唑磷 (2Z)-3-[[(4-氯苯基)氨基]-2-氰基丙烯酸乙酯 (2S,3S,5S)-5-(叔丁氧基甲酰氨基)-2-(N-5-噻唑基-甲氧羰基)氨基-1,6-二苯基-3-羟基己烷 (2S,2''S,3S,3''S)-3,3''-二叔丁基-4,4''-双(2,6-二甲氧基苯基)-2,2'',3,3''-四氢-2,2''-联苯并[d][1,3]氧杂磷杂戊环 (2S)-(-)-2-{[[[[3,5-双(氟代甲基)苯基]氨基]硫代甲基]氨基}-N-(二苯基甲基)-N,3,3-三甲基丁酰胺 (2S)-2-[[[[[[((1R,2R)-2-氨基环己基]氨基]硫代甲基]氨基]-N-(二苯甲基)-N,3,3-三甲基丁酰胺 (2-硝基苯基)磷酸三酰胺 (2,6-二氯苯基)乙酰氯 (2,3-二甲氧基-5-甲基苯基)硼酸 (1S,2S,3S,5S)-5-叠氮基-3-(苯基甲氧基)-2-[(苯基甲氧基)甲基]环戊醇 (1-(4-氟苯基)环丙基)甲胺盐酸盐 (1-(3-溴苯基)环丁基)甲胺盐酸盐 (1-(2-氯苯基)环丁基)甲胺盐酸盐 (1-(2-氟苯基)环丙基)甲胺盐酸盐 (-)-去甲基西布曲明 龙胆酸钠 龙胆酸叔丁酯 龙胆酸 龙胆紫 龙胆紫 齐达帕胺 齐诺康唑 齐洛呋胺 齐墩果-12-烯[2,3-c][1,2,5]恶二唑-28-酸苯甲酯 齐培丙醇 齐咪苯 齐仑太尔 黑染料 黄酮,5-氨基-6-羟基-(5CI) 黄酮,6-氨基-3-羟基-(6CI) 黄蜡,合成物 黄草灵钾盐