20-(2-Hydroxyacetyl)oxyicosyl 2-hydroxyacetate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 20-(2-Hydroxyacetyl)oxyicosyl 2-hydroxyacetate
• 英文别名: 20-(2-hydroxyacetyl)oxyicosyl 2-hydroxyacetate
• 化学式: C₂₄H₄₆O₆
• 分子量: 430.6
• InChiKey: HNYCSUALZYITOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  30
• 可旋转键数：
  25
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  20-(2-Hydroxyacetyl)oxyicosyl 2-hydroxyacetate 225.0 ℃ 、1.0 kPa 条件下， 以78.02 %的产率得到1,4-二氧杂环-2,5-己二酮
  参考文献：
  名称：

  A METHOD FOR SYNTHESIZING GLYCOLIDE

  摘要：

  This invention provides a method for synthesizing glycolide using methyl glycolate as a raw material, comprising two steps as illustrated in the following reaction formulas: wherein, the ROH represents a straight/branched chain alcohol, acid or ester containing 18-30 carbons and at least one hydroxyl group. The method for glycolide synthesis disclosed in the present invention manages to maintain a low viscosity within the reaction system by introducing a high-boiling alcohol into the reaction system to form a larger alkoxy glycolate exhibiting a significantly lower molecular weight compared to the typical glycolic acid oligomers utilized in the conventional process. Thus the challenges of coking and inefficient heat transfer encountered in traditional glycolide synthesis routes are effectively addressed.

  公开号：

  US20240287017A1
• 作为产物：
  描述：

  羟乙酸甲酯 、 1,20-二十烷二醇 在 antimony(III) trioxide 作用下， 80.0~180.0 ℃ 、101.33 kPa 条件下， 生成 20-(2-Hydroxyacetyl)oxyicosyl 2-hydroxyacetate
  参考文献：
  名称：

  A METHOD FOR SYNTHESIZING GLYCOLIDE

  摘要：

  This invention provides a method for synthesizing glycolide using methyl glycolate as a raw material, comprising two steps as illustrated in the following reaction formulas: wherein, the ROH represents a straight/branched chain alcohol, acid or ester containing 18-30 carbons and at least one hydroxyl group. The method for glycolide synthesis disclosed in the present invention manages to maintain a low viscosity within the reaction system by introducing a high-boiling alcohol into the reaction system to form a larger alkoxy glycolate exhibiting a significantly lower molecular weight compared to the typical glycolic acid oligomers utilized in the conventional process. Thus the challenges of coking and inefficient heat transfer encountered in traditional glycolide synthesis routes are effectively addressed.

  公开号：

  US20240287017A1